DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD1 and nsd1b

DIOPT Version :10

Sequence 1:NP_071900.2 Gene:NSD1 / 64324 HGNCID:14234 Length:2696 Species:Homo sapiens
Sequence 2:XP_005173940.1 Gene:nsd1b / 564592 ZFINID:ZDB-GENE-080519-2 Length:1873 Species:Danio rerio


Alignment Length:2334 Identity:899/2334 - (38%)
Similarity:1172/2334 - (50%) Gaps:637/2334 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   135 SPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCNYETKS 199
            ||:..:..:....|| ||||:. ..:|.:.|..|||| ||::.|                     
Zfish    14 SPDFSLDSSSPFANG-LHFESI-LFEDEEEDEVMDPE-PVSQPE--------------------- 54

Human   200 ENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDG----SNEKAALLPAPFSL 260
                :...||..|.|                    |..|.:.| :||    .|.||         
Zfish    55 ----RNLCGSTSDCT--------------------TNTNLKTN-LDGKSRRKNSKA--------- 85

Human   261 GDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPG-----TSSSSTSQELPFCQPKKKSTPLK 320
               :.::|:     ::.|||.. .|.|.|..::..||     ....|.::.||         |:|
Zfish    86 ---HSSLEQ-----DVVFQDKA-KSDSGLSTLVSRPGGVLMKQKKKSKTKALP---------PVK 132

Human   321 YEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVM 385
            |..|::|||||.|||||||::...||...:.|||....|..|||:::.||:|.|:|||..::..:
Zfish   133 YLEGEVIWAKFNRRPWWPCQVIIHPLEGVYHKMKEPPDRTTRQYFLKTFGEPEEQAWVPERSTHI 197

Human   386 FEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGS-IKL 449
            |.|.:||..||.::..|.|:::..||.:|::.|:.|.|||..||...:   .|.|...|.| .|.
Zfish   198 FVGGYQFNNLPFVKGSGHQRDENTRHSIPKRFLNSWSASVVAAEALLL---EKPRVTSPSSAFKT 259

Human   450 DSEE-------------DMPFEDCTNDPESEHDLLLNGC------LKSLAFDSEHSADEKEKP-- 493
            .|||             |:|          ....|:||.      |.||..:  ..:..|:||  
Zfish   260 ISEETINNTEIKVSVPVDLP----------NSSFLINGAVIQNNHLNSLPHN--RKSKNKKKPTI 312

Human   494 ----------CAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQAS 548
                      |.|.....:.|:|        :...::....||  .|:           |:.|.|
Zfish   313 SHCRISEELNCEKGMIMDALDSP--------YSDIDSVPQIRR--FPK-----------SNEQIS 356

Human   549 N-------ELSRIANSLTGSNTA--------PGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGAL 598
            |       :.|.....|..:|..        .|...||..||...       ||.|..|:     
Zfish   357 NHYVINYKQSSATPTVLPSTNDKDVKKNVENQGGLWFSKTGKGQV-------NGISRAGI----- 409

Human   599 ISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVL 663
                        :|:.|......|.|      |..||.|: ...|:.::.|   ||.|      .
Zfish   410 ------------KSVNCSFGKVSCKI------KMPDSASM-KPKDNHNTGL---EHLS------T 446

Human   664 EIPDAFDRTENML---------SMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCTKSA 719
            |...|.||....|         :::..|..::::.::::...|                .|..|.
Zfish   447 EAKKALDRRVKCLPASSRLMTRALKAMEDAEWTKESSSDLETK----------------NCVSSF 495

Human   720 E-PGTETSQVNLSDL---KASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHS 780
            : |..|||.|:.|.|   ..:..:|    |...|:   |.:..:.:|||                
Zfish   496 DSPSLETSDVHNSILLQKMPTAAIH----DLKEDS---KISTHAKLSSE---------------- 537

Human   781 KSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEK 845
                    .:.||..|:.|.:|     :|.||      ...:|.|..|.:.|       .|.|..
Zfish   538 --------LLCCKDDEHSVKSE-----DESSL------VSQAPCAFHSSTRK-------QNSHVN 576

Human   846 TRDSSDIETAVVKHV----LSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPD-- 904
            ...||...:.   |:    :..:.|:|::||..:.|       .:||.|           .||  
Zfish   577 DLSSSPTPSL---HLNLKDMDNMNEISFKSLANEHS-------GQPLSF-----------HPDSN 620

Human   905 YKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKG 969
            |||||.||||||||||:.|                                              
Zfish   621 YKFSTFLMMLKDMHDSREK---------------------------------------------- 639

Human   970 DGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSK-LRDA 1033
            ||......|.|       :.||....|.|:||.:|..|:.|.:          :.||.:. :.:.
Zfish   640 DGNVLVVEPLP-------TTELINEEPLLISDVKDEKATSKQK----------KVKPKTNVMSEN 687

Human  1034 FSAQMVKNTVNRKALKTERKRKLNQLPS----VTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIM 1094
            ..|..:..|..|.:.|...|:|...:.:    .:.|.::...|                      
Zfish   688 HLASTISKTAQRSSKKISLKKKTTDIKANIDYKSFDKLISAHR---------------------- 730

Human  1095 GHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKR 1159
              |||::    ::.:|.:.                                         |||||
Zfish   731 --LTSKE----AETNFSAN-----------------------------------------VPKKR 748

Human  1160 WQRLNQRRTK-----PRKRMNRFKEKENSECAFRVLLPSDPVQEGRDE---FPEHRTPSASILEE 1216
            ||:.:|...|     ....:::.:...:..|        |...:|.::   |....|.:|     
Zfish   749 WQKFDQVSEKTVHIVEGNCIHKTERVSSENC--------DVSMDGTNKSCFFGPETTSNA----- 800

Human  1217 PLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWL 1281
              .|.|..:|.::..|                                    :|.||:|||||.|
Zfish   801 --LECNQGNCQNTEAP------------------------------------TECKRIRKPSKRL 827

Human  1282 LEYTEEYDQIFAPKKKQKKVQEQVHKV-SSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVL 1345
            :|:||||||:|:.|||.||..:.|.|: :.:|.|...          |..||     .|::|.|.
Zfish   828 IEWTEEYDQLFSAKKKAKKKPDSVTKIENQKCSEPVA----------KTYDE-----VKQKPQVT 877

Human  1346 E----REAPFLEG----------------PLAQSELGGGHAELPQLTLSVPVAPEVSPRPA---L 1387
            |    |..|.|:.                |..:|::      |...||:.|  ||:.|.|.   .
Zfish   878 EQDVSRRLPELQTPPPEDQSQSTPLINTLPCQESQV------LSAETLTPP--PEIIPSPCDNIS 934

Human  1388 ESEELLVKTP---GN---YESKRQRKPTKKLLESN-DLDPGFMPKKGDLGLSKKCYEAGHLEN-G 1444
            ..::|..:.|   |:   ..||||||||||:|||: :.:|..:||:  ...|.|...:||..| |
Zfish   935 NRDQLQRQNPVAVGDSVCLNSKRQRKPTKKILESSIEAEPILIPKR--KMKSMKICSSGHSTNSG 997

Human  1445 ITESCATSYSKDFGGGTTKIFDKPRKRKRQRH---AAAKMQCKKVKN-DDSSKEIPGSEGELMPH 1505
            :.:..:.|.:|.....:....| |..:..:..   :.|.:|....:: ||.|..:..|..::...
Zfish   998 VEQQSSKSKNKLSIESSDPPSD-PMLKSTEMEIDVSPAVLQTINTESADDGSDTLRCSGSQMTES 1061

Human  1506 RTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLEC 1570
            ....|.:   ||..:.|..:..|:::..|:||..::|||||..|||.|:|||||.|||||||.:|
Zfish  1062 SEFYSER---EENSQSDKVLLDSRRLSEEKGGSTSVKENVCPMCEKQGDLLLCEGQCCGAFHPQC 1123

Human  1571 LGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRC 1635
            .||.|.|.|||:|.||.:|:|:||.||:.||||:||::|.||||||.||...:.|||..|:.|||
Zfish  1124 TGLNEPPTGKFLCQECTSGVHSCFACKRLGEDVRRCMVPGCGKFYHGECAASHAPTVPLNRAFRC 1188

Human  1636 SLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCR 1700
            .||.|::|...||||.|.:||:|.||:|||||||::|||:.|||..|..::|:||||||||:|||
Zfish  1189 PLHACLSCFILNPANPSVAKGQLTRCIRCPVAYHSSDFCIPAGSVTLTDSNIVCPNHFTPRKGCR 1253

Human  1701 NHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVG 1765
            ||||||||||||||||||||||:||||||||||||||:|||:||||||:|||||||:|:||||||
Zfish  1254 NHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDCRAGKKPHYKEVVWVKVG 1318

Human  1766 RYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGV 1830
            ||||||||:.:|:.:|.||.:|:|||||||||||||||||||:|||||||||||.:||:||||||
Zfish  1319 RYRWWPAEVSNPKDIPENILRMKHDVGEFPVLFFGSNDYLWTYQARVFPYMEGDANSKEKMGKGV 1383

Human  1831 DGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRC 1895
            |.||||||.|||.||:||:|:||||||||||:|||||||||.||||:|.|:|.|.:|||||||||
Zfish  1384 DSTYKKALDEAALRFKELQAEKELRQLQEDRRNDKKPPPYKQIKVNKPFGKVLIISADLSEIPRC 1448

Human  1896 NCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKT 1960
            |||||||||||:|||||||||||||||.|||||.|||||||.||||.:||.||||.||||||...
Zfish  1449 NCKATDENPCGMDSECINRMLLYECHPQVCPAGERCQNQCFIKRQYCQVETFRTLSRGWGLRCVH 1513

Human  1961 DIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQP 2025
            |||||.|::|||||:||||||||||::|||::|.||||||||||||||||||||.||||||||||
Zfish  1514 DIKKGGFISEYVGEVIDEEECRARIKHAQENNIGNFYMLTLDKDRIIDAGPKGNEARFMNHCCQP 1578

Human  2026 NCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPI 2090
            |||||||:||||||||||:|:||.|||||||||||||||||||||||||.||||||||||||.| 
Zfish  1579 NCETQKWTVNGDTRVGLFSLTDIPAGTELTFNYNLECLGNGKTVCKCGASNCSGFLGVRPKNNP- 1642

Human  2091 ATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAG 2155
            .:::|.:|.||    ||::|.|:.||||||||||||.||:||||:||||||||||||||||||||
Zfish  1643 PSDDKGRKLKK----KRKSQQEVIKEREDECFSCGDGGQIVSCKRPGCPKVYHADCLNLTKRPAG 1703

Human  2156 KWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIRE 2220
            :|||||||||:||:||||||||||||:|.:||:||||||||||||||:|||||||.|||||||||
Zfish  1704 RWECPWHQCDLCGQEAASFCEMCPSSYCVEHRDGMLFISKLDGRLSCSEHDPCGPEPLEPGEIRE 1768

Human  2221 Y------------------------VPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQM 2261
            |                        .|..||..|.|           ...||::|..|       
Zfish  1769 YPGELRPTYPINIIKSAKNKSHILNTPKAVPQAPSP-----------LDVAPQVSPSP------- 1815

Human  2262 LSLSKKALAGTCQRPLL------PERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQR 2314
                      :|..|.|      |..|....:.:.:..:.|..|...|.||.....|:|
Zfish  1816 ----------SCSPPPLTIFLNGPYSPNSSYEEKKEEEESVTLLEKDGEKSVPRDKSER 1864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSD1NP_071900.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..252 11/48 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..311 8/34 (24%)
PWWP_NSD1_rpt1 318..433 CDD:438989 50/114 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..514 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..891 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 936..1035 15/99 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093 1/25 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1134 0/21 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1272 1/28 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1344 14/50 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1428 21/55 (38%)
TNG2 <1431..1587 CDD:227367 55/160 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1534 10/54 (19%)
PHD1_NSD1_2 1545..1587 CDD:277118 28/41 (68%)
PHD2_NSD1 1592..1638 CDD:277120 26/45 (58%)
PHD3_NSD1 1639..1692 CDD:277123 29/52 (56%)
PHD4_NSD1 1709..1748 CDD:277126 35/38 (92%)
PWWP_NSD1_rpt2 1755..1850 CDD:438992 74/94 (79%)
AWS 1901..1939 CDD:465559 33/37 (89%)
SET_NSD1 1941..2082 CDD:380987 118/140 (84%)
Inhibits enzyme activity in the absence of bound histone 2060..2066 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2091..2111 6/19 (32%)
PHD5_NSD1 2120..2162 CDD:277129 37/41 (90%)
C5HCH 2161..2210 CDD:465605 41/48 (85%)
PHA03247 <2208..2574 CDD:223021 34/137 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2422 30/132 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2464..2499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2553..2575
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2595..2616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2665..2696
nsd1bXP_005173940.1 PWWP 130..244 CDD:470613 50/113 (44%)
PHD_SF 1098..1140 CDD:473978 28/41 (68%)
PHD_SF 1145..1191 CDD:473978 26/45 (58%)
PHD_SF 1193..1245 CDD:473978 29/51 (57%)
PHD4_NSD1 1262..1301 CDD:277126 35/38 (92%)
PWWP 1308..1403 CDD:470613 74/94 (79%)
AWS 1454..1492 CDD:465559 33/37 (89%)
SET 1494..1635 CDD:394802 118/140 (84%)
PHD5_NSD1 1668..1710 CDD:277129 37/41 (90%)
C5HCH 1709..1758 CDD:465605 41/48 (85%)
Blue background indicates that the domain is not in the aligned region.

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