DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD1 and NSD

DIOPT Version :10

Sequence 1:NP_071900.2 Gene:NSD1 / 64324 HGNCID:14234 Length:2696 Species:Homo sapiens
Sequence 2:NP_733239.1 Gene:NSD / 43351 FlyBaseID:FBgn0039559 Length:1427 Species:Drosophila melanogaster


Alignment Length:1542 Identity:389/1542 - (25%)
Similarity:613/1542 - (39%) Gaps:378/1542 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   835 GLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHI 899
            |..|.|:..:....:.::.....:.|.:|         |:||.....:..|.|:.......||.:
  Fly    18 GNVLCNSASDSLTATDEVAAGNDESVATE---------GDDVEIPRDTNNSTPVRLLDKPGQNPV 73

Human   900 P--IEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQ------NLVSYRSPGR-GDCSTNSPVGVS-- 953
            .  .:|..:.|.|... :.....|.::||:....      ||.|..||.. |..:.|||..:|  
  Fly    74 QNGAQPAAEESELESQ-RQTPVQKQQQQRVSMVNRKRDLINLQSALSPKYIGYANANSPTPLSDS 137

Human   954 -------KVLVSGGSTHNSEKKGDG-TQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGK 1010
                   :..|:..:..|:...|:. ..::|:|...||.....|:.||:  .|||.....|.   
  Fly   138 DDTIRTTRRRVNQAAALNNSSAGETLAHDNASPRTPGGGGGGGGDDSAN--QLLSKTYMSPI--- 197

Human  1011 SRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLP--SVTLDAVLQGDRE 1073
               :.:..:| |.|.|:|...:|.|..:....:.||.:    |||:.::|  .|||:...:..:|
  Fly   198 ---EKLLIKN-GASSPNSTGFEAGSEDLGIRPIVRKHV----KRKMKRVPKAKVTLELDEKNQQE 254

Human  1074 RGGSLRGGAEDPSKEDPLQIMGHLTSE-----------------DGDHFS--DVHFDSKVKQSDP 1119
            ..       |...|.:|:......|.|                 :.:|.:  |||    :||.|.
  Fly   255 VD-------EKSVKTEPIDEEVDRTDEAPTQEAQTTAISIKSETEAEHKAAVDVH----IKQEDT 308

Human  1120 GKI-----------------------SEKGLSF----------ENGKGPELDSVMNSEN------ 1145
            .::                       |.:.|:|          :....|:|.|...:.:      
  Fly   309 IRLDIVNNPVESTSIVITEEPKDLEKSTEELAFALPLASSTEVDLKSPPDLSSTALATSIKSPSS 373

Human  1146 ---DELNGVNQVVPKKRWQRLNQRRTKPRKRM-NRFKEKENSECAFRVLLPSDPVQEGRDEFPEH 1206
               |...|:: :|....|         |..:: :.|..|..|.|.:..::..||:.:.....|.|
  Fly   374 VSIDSAKGLS-IVTDPGW---------PTYQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSH 428

Human  1207 RTPSASILEE---PLTEQNHADCLDSAGPRLNVCDKSSASIG------DMEKE----PGIPSLTP 1258
              |..|.|:.   |:  |.|.......|.|..:..::..:..      ||.:|    .|..|...
  Fly   429 --PQRSSLDNANVPI--QVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKY 489

Human  1259 QAELPE--------PAVRSEKKRLRKP-SKWLLEYTEEYDQIFA-PKKKQKKVQEQVHKVSSRCE 1313
            :..:|:        .|:...:...:.| |..|.::.:.|:.:.. .::|:|:.:..:...|   :
  Fly   490 RQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENVVTLNRQKRKRTKYMMQDTS---D 551

Human  1314 EESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVA 1378
            ..|.|.....:..|||  ...|::.|.|    ..|:||                          :
  Fly   552 VGSSLYDSTDNLHNKQ--GTQLLAVKRE----RSESPF--------------------------S 584

Human  1379 PEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPG-----FMPKKGDLGLSKKCYE- 1437
            |..||          ||:.....:||     :||....:.|.|     ..|.:.:..:....|| 
  Fly   585 PAFSP----------VKSKNEKRAKR-----RKLSNGTEADTGSNSMAVTPSQTETTVDSSAYEN 634

Human  1438 --------------------------------------------------AGHLENGITESCATS 1452
                                                              :|.:|..:..|..  
  Fly   635 PEFRQLLSAVMEYVMMNRSDEKVEKVLLSVVSNIWSLKQIQLRELERDLASGEIEEPLGSSVV-- 697

Human  1453 YSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKET--- 1514
             .:..|.||.         ||..:....|..::......:.....:..|  |.|..:.|.:|   
  Fly   698 -GRGSGVGTI---------KRLSNRLMTMMVRRSMTPVVTPSTTPAPSE--PDRRLSEPPKTKKP 750

Human  1515 ----VEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLG-ELLLCEAQCCGAFHLECL--- 1571
                :||.:|....:.:....:|      ..:|.:|:.|.:.| :|:.|...|....|.:||   
  Fly   751 VNRPIEEVIEDILQLDSKYLFRG------LSREPICKYCYQAGSDLVRCSRTCSSWLHADCLERK 809

Human  1572 -------------GLTEMPRGK----------------------FICNECRTG-IHTCFVCKQ-- 1598
                         .|...|..|                      .:|:||..| ...|.:|.|  
  Fly   810 VTGAPMPKIGSRKALVIPPTSKSPSPDEDHVTADAKEVVAVGTSLVCHECNVGEPEGCVICHQVE 874

Human  1599 --------SGED----------VKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHA 1645
                    ..||          :..|..|:|||.:|..|.:.:|.........||..|:|.||.:
  Fly   875 SPAVPSTPRKEDSSSHTPIEDKLLTCSQPMCGKRFHTSCCKYWPQASSSKHSARCPRHVCHTCVS 939

Human  1646 ANPANVSASKG--RLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVS 1708
            .:|:......|  :|.:|||||..||....|:.||:::|.:.:||||.|...:...    ||||.
  Fly   940 DDPSGKFQQLGSSKLAKCVRCPATYHQLSKCIPAGTQMLNTTNIICPRHNIAKADA----HVNVL 1000

Human  1709 WCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWY-CNDCKAGKKPHYREIVWVKVGRYRWWPA 1772
            ||::|.:||.|:||::||.|.|..|.||.|.....| |.:|::|:.|.|.||||.|...:|||||
  Fly  1001 WCYICVKGGELVCCETCPIAVHAHCRNIPIKTNESYICEECESGRLPLYGEIVWAKFNNFRWWPA 1065

Human  1773 EICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKA 1837
            .|..|..|||||.|..|...:|.|.|||::|:.|..:.||:.|:|||.....|....:...|...
  Fly  1066 IILPPTEVPSNILKKAHGENDFVVRFFGTHDHGWISRRRVYLYIEGDTGDGHKTKSQLFRNYTTG 1130

Human  1838 LQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDE 1902
            ::||:.....:||:::.:.::....|...||||..||.|:.:..:: |:.:|.::..|||...||
  Fly  1131 VEEASRFLPIIKARRQEQDMERQSGNKLHPPPYVKIKTNKAVPPLR-FSQNLEDLSTCNCLPVDE 1194

Human  1903 NPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEF 1967
            :|||.::.|:||||..||:|..|.||..|:|:.|.:|:.|.:|:....:||:||..:..|..|:|
  Fly  1195 HPCGPEAGCLNRMLFNECNPEYCKAGSLCENRMFEQRKSPRLEVVYMNERGFGLVNREPIAVGDF 1259

Human  1968 VNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKW 2032
            |.|||||:|:..|.:.|:...|.....|:|.|.::||.|||||||||.||||||.|:||||||||
  Fly  1260 VIEYVGEVINHAEFQRRMEQKQRDRDENYYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKW 1324

Human  2033 SVNGDTRVGLFALSDIKAGTELTFNYNL-ECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKS 2096
            :||...|||:||:.||...:||||||.. :.:.|.|..|.|||..|||.:|.:.|:..:....|.
  Fly  1325 TVNCIHRVGIFAIKDIPVNSELTFNYLWDDLMNNSKKACFCGAKRCSGEIGGKLKDDAVKAHAKL 1389

Human  2097 KKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYH 2143
            |:.::.:....|                      :..|....|||.|
  Fly  1390 KQMRRAKASAVR----------------------IHVKPKKTPKVKH 1414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSD1NP_071900.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..252
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..311
PWWP_NSD1_rpt1 318..433 CDD:438989
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..514
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..891 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 936..1035 27/109 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1134 6/54 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1272 7/46 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1344 11/49 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1428 11/50 (22%)
TNG2 <1431..1587 CDD:227367 35/252 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1534 9/60 (15%)
PHD1_NSD1_2 1545..1587 CDD:277118 14/80 (18%)
PHD2_NSD1 1592..1638 CDD:277120 15/65 (23%)
PHD3_NSD1 1639..1692 CDD:277123 21/54 (39%)
PHD4_NSD1 1709..1748 CDD:277126 18/39 (46%)
PWWP_NSD1_rpt2 1755..1850 CDD:438992 37/94 (39%)
AWS 1901..1939 CDD:465559 19/37 (51%)
SET_NSD1 1941..2082 CDD:380987 72/141 (51%)
Inhibits enzyme activity in the absence of bound histone 2060..2066 0/6 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2091..2111 3/19 (16%)
PHD5_NSD1 2120..2162 CDD:277129 5/24 (21%)
C5HCH 2161..2210 CDD:465605
PHA03247 <2208..2574 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2422
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2464..2499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2553..2575
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2595..2616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2665..2696
NSDNP_733239.1 PWWP_NSD_rpt1 395..514 CDD:438972 23/122 (19%)
PHD2_NSD 867..932 CDD:277040 15/64 (23%)
PHD3_NSD 933..988 CDD:277041 21/54 (39%)
PHD4_NSD 1001..1041 CDD:277042 18/39 (46%)
PWWP_NSD_rpt2 1048..1143 CDD:438963 37/94 (39%)
AWS 1183..1233 CDD:197795 23/49 (47%)
SET_NSD 1233..1375 CDD:380950 72/141 (51%)
Blue background indicates that the domain is not in the aligned region.

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