Protein Alignment NSD1 and set2

DIOPT Version :10

• Sequence 1: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Sequence 2: NP_594980.1
• Gene: set2 / 2542070
• PomBaseID: SPAC29B12.02C
• Length: 798
• Species: Schizosaccharomyces pombe
• Alignment Length: 836
• Identity: 196/836 - (23%)
• Similarity: 308/836 - (36%)
• Gaps: 227/836 - (27%)

Human  1811 RVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKV 1875
            ::|.:::   |:|||               |...||      |:::.|....|..|||.
pombe    89 QLFHHLD---SAKDK---------------ALTTFE------EIQECQYASANIGKPPE------ 123

Human  1876 NRPIGRVQIFTADLSEIPRCNCKATDENP---------CGIDSECINRMLLYEC--HPTVCPAGG 1929
                          :|...|:|:     |         ||..|.|||||...||  ...||  |.
pombe   124 --------------NEAMICDCR-----PHWVDGVNVACGHGSNCINRMTSIECTDEDNVC--GP 167

Human  1930 RCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDIT 1994
            .||||.|.:.::.:|::|.|.::|:|||...::.|..||.||:||:|.|::.|.|:|......|.
pombe   168 SCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIK 232

Human  1995 NFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYN 2059
            :||.:.|.|...|||..:|:.|||.||.|:|||...||.|....|:|:|...||..|.||||:||
pombe   233 HFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYN 297

Human  2060 LECLGNGKTVCKCGAPNCSGFLGVR---------PKN--QPIATEEKSKKFK----KKQQGKR-- 2107
            ::..|.....|.||.|.|.|::|.:         |:|  :.:..|::...::    ::|:.|:
pombe   298 VDRYGAQAQPCYCGEPCCVGYIGGKTQTEAQSKLPENVREALGIEDEEDSWENITARRQRRKKGI 362

Human  2108 ----------------------------RTQGE-ITKEREDECFSCGDAGQLVSCKKPGCPKVYH 2143
                                        :|:.: :|::..:..|...|..   .|:.....:.|:
pombe   363 DETSKIIEEVQPTPLTSESATKVIGVLLQTKDDLLTRKLMERIFLTSDPS---VCRSIIALRGYN 424

Human  2144 ADCLNLTKRPAG--------KWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRL 2200
            ...|.|.|....        |....|.:. ...|...|..|.....||....|
pombe   425 IFGLMLKKFSIDIEFILRSIKTMLSWPRL-TRNKIQDSNIEPVVQEFCDHENE------------ 476

Human  2201 SCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTG-----MAAQAPKMSDK---PPAD 2257
            ...:|........|..||...:|...|....|.:..||.|..     :..|.|:..||   ..|.
pombe   477 EVKDHAKTLLKEWESLEIAYRIPRRKPGQVAPQSTNAEPSNNQSNPPLRDQEPQRGDKGDIKSAI 541

Human  2258 TNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAV 2322
            .|....||||..|....||         :|||.      |...|:..:|.|..:..|....|
pombe   542 NNSTEDLSKKHPALHSSRP---------SDSRS------RSKFGNDYQSHSKHNLFRKNSFP--- 588

Human  2323 AGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLP 2387
              .|.:||:..:|  |.:::|:...:.:.......|  |:|.|.||      :|..:....|:..
pombe   589 --KRRRLSNSDTP--SETTTPNNEQEQVSNQANKVD--LNKIISAA------MESVNQKNVLKAQ 641

Human  2388 PPDRLLITSSPK--------PQTSDRPTDKPH---------ASLSQRLP--PPEKV-LSAVVQTL 2432
            ..:...|....:        .::..|...|.|         |::...|.  .||.: ..||:...
pombe   642 KEEEERIAQQKREEKRRLAYEESLKRHAKKLHEKKTKSSQDATIDHHLTSHSPESIAFKAVLAKF 706

Human  2433 VAKEKA-----LRPVDQNTQSKNRAALVMDL-IDLTPRQKERAASPHQVTPQADEKMPVLESSSW 2491
            .|.:.|     |...:...:.|....:::.. |.|...:||:|. |.:::.....|:.|     |
pombe   707 FANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEKAL-PDELSDSQQRKLRV-----W 765

Human  2492 PASKGLGHMPRAVEKGCVSDPLQTSGKA-AAPSEDPWQAVKSLTQARLLSQPPAKA 2546
                ...::...|.:         ||.| ..|::.|           .:.:.|.||
pombe   766 ----AFRYLDTVVSR---------SGTATTTPTDSP-----------SIGESPKKA 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311
		PWWP_NSD1_rpt1	318..433	CDD:438989
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428
		TNG2	<1431..1587	CDD:227367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		PWWP_NSD1_rpt2	1755..1850	CDD:438992	8/38 (21%)
		AWS	1901..1939	CDD:465559	19/48 (40%)
		SET_NSD1	1941..2082	CDD:380987	59/140 (42%)
		Inhibits enzyme activity in the absence of bound histone	2060..2066		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111		4/53 (8%)
		PHD5_NSD1	2120..2162	CDD:277129	8/49 (16%)
		C5HCH	2161..2210	CDD:465605	8/48 (17%)
		PHA03247	<2208..2574	CDD:223021	77/374 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422		51/235 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696
set2	NP_594980.1	AWS	125..179	CDD:197795	22/60 (37%)
		SET_SETD2	179..320	CDD:380949	59/140 (42%)
		Med26	440..489	CDD:462573	9/61 (15%)
		SRI	699..776	CDD:462404	16/86 (19%)