Protein Alignment NSD1 and pdp2

DIOPT Version :10

• Sequence 1: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Sequence 2: NP_596684.1
• Gene: pdp2 / 2540653
• PomBaseID: SPBC215.07C
• Length: 568
• Species: Schizosaccharomyces pombe
• Alignment Length: 666
• Identity: 131/666 - (19%)
• Similarity: 215/666 - (32%)
• Gaps: 206/666 - (30%)

Human   165 DSEMDPEQPVTEDES---IEEIFEETQTNATCNYETKSENG---VKVAMGSEQDSTPESRHGAVK 223
            ||.:..|.|..::||   :|.....|.||.:.|.||.|.||   :|:......|...:.:....|
pombe     6 DSSVKDENPGKQEESSIAVESREMSTATNNSKNIETTSSNGAEDIKIQRDVGDDKDLDDKEANDK 70

Human   224 SPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTST 288
            |             :|...|...|.::.              |||....|.|:.   |..|..|.
pombe    71 S-------------SKGLEEESDSKDRK--------------TIETDQPSNNIG---DIKSQKSE 105

Human   289 LGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKM 353
            ..|     |.:...|          |:|..:.|:.|..:..|....||||      .::.|.|||
pombe   106 KSN-----GNARKET----------KQSERVNYKPGMRVLTKMSGFPWWP------SMVVTESKM 149

Human   354 KVSNR--RPYR--QYYVEAFGDPSERAWVAGKAI--VMFEGRHQFEELPVLRRRGKQKEKGYRHK 412
            ....|  :|.|  .:|...|....|..|....::  :..|...||.|.|        |.|
pombe   150 TSVARKSKPKRAGTFYPVIFFPNKEYLWTGSDSLTPLTSEAISQFLEKP--------KPK----- 201

Human   413 VPQKILSKWEASVGLAEQYDVPKGSK--NRKCIPGSIKLDSEED--------MPFEDCTNDPESE 467
                       :..|.:.|.:.:.:.  :...:|.|....|||:        .|.|:..||.::.
pombe   202 -----------TASLIKAYKMAQSTPDLDSLSVPSSESEVSEEESDQEMSEPSPIEEDYNDTKAR 255

Human   468 HDLLLNGCLKSLAFD-SEHSADEK---------EKPCAKSR---------ARKSSDNPKRTSVKK 513
            .........|::.|| |..|..:|         ..|..|:|         ::|.|.:.||.|..
pombe   256 RITRKGTKKKTVTFDPSLESVPQKRLNASSNVSSNPAKKTRVSPRRSTAASKKKSPSSKRASSD- 319

Human   514 GHIQFEAHKDERRGKI------------PENLGLNFISGDISDTQAS--------------NELS 552
               :.|..|:|..|.:            .....|.|:...:..:..|              |.|.
pombe   320 ---EIEKDKEEEEGSVANEEDVAKRTFHSREQSLLFLRHKLQSSLLSPKQDLSQVDYKLVHNYLD 381

Human   553 RIAN----------------------SLTGSNTAPGSFLFSSCG---KNTAKKEFETSNGDSLLG 592
            ::||                      ||.|........:.|.||   :|..|
pombe   382 KLANFQGIDVPLIQKTKIAVVVRKIFSLAGLPKENEDEVKSICGDILENRWK------------- 433

Human   593 LPEGALISKCSREK-------NKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLD 650
                :|:.:.|.:|       .....|:...::.::..:..|.|.|.:.|......:|...::.:
pombe   434 ----SLLQEISSQKQLSTDASQTQDASIANENETEIASLDEGSESKPTPSPPAEQLTDQKQNEDN 494

Human   651 PIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGC 715
            ..:..::|:.......:..|.:::|:|.:|:     |:.|..:..|..|.........|.:|
pombe   495 EDKVKADSNGPTQNENETADASKDMISEEKS-----SKDADNSLEVAGKDFAEDGTEQTPNL--- 551

Human   716 TKSAEPGTETSQVNLS 731
               |||....:.|:||
pombe   552 ---AEPEDGVAAVDLS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252		6/44 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311		6/29 (21%)
		PWWP_NSD1_rpt1	318..433	CDD:438989	27/120 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514		9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428
		TNG2	<1431..1587	CDD:227367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		PWWP_NSD1_rpt2	1755..1850	CDD:438992
		AWS	1901..1939	CDD:465559
		SET_NSD1	1941..2082	CDD:380987
		Inhibits enzyme activity in the absence of bound histone	2060..2066
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111
		PHD5_NSD1	2120..2162	CDD:277129
		C5HCH	2161..2210	CDD:465605
		PHA03247	<2208..2574	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696
pdp2	NP_596684.1	PWWP_ScIOC4-like	126..216	CDD:438965	26/119 (22%)