Protein Alignment NSD1 and pdp1

DIOPT Version :10

• Sequence 1: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Sequence 2: NP_595841.1
• Gene: pdp1 / 2540354
• PomBaseID: SPBC29A3.13
• Length: 359
• Species: Schizosaccharomyces pombe
• Alignment Length: 288
• Identity: 63/288 - (21%)
• Similarity: 96/288 - (33%)
• Gaps: 74/288 - (25%)

Human   324 GDLIWAKFKRRPWWPCRIC----SDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIV 384
            ||.|..|....||||..:.    :...:||:|...|       .|.|..|.| ...|||...::.
pombe    53 GDRILVKAPGYPWWPALLLRRKETKDSLNTNSSFNV-------LYKVLFFPD-FNFAWVKRNSVK 109

Human   385 MFEGRHQFEELPVLRRRGKQKEKGYR-HKVP--------------------------QKILSKWE 422
            ........:.|...:|:.|:..:.|. .|.|                          ||....||
pombe   110 PLLDSEIAKFLGSSKRKSKELIEAYEASKTPPDLKEESSTDEEMDSLSAAEEKPNFLQKRKYHWE 174

Human   423 ASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSA 487
            .|:..::...:..||..      ||...||...|....|:...::    |:.....|:.:.:|..
pombe   175 TSLDESDAESISSGSLM------SITSISEMYGPTVASTSRSSTQ----LSDQRYPLSSNFDHRG 229

Human   488 DEKEK-------PCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENL-----------G 534
            :.|.|       |..:.|...||....:|......:.|..||.::....|::|           .
pombe   230 EAKGKGKQPLKNPQERGRISPSSPLNDQTKALMQRLLFFRHKLQKAFLSPDHLIVEEDFYNASKY 294

Human   535 LNFISGD-------ISDTQASNELSRIA 555
            ||.||..       |:.|:.:..|.|||
pombe   295 LNAISDIPFLNYELITSTKLAKVLKRIA 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311
		PWWP_NSD1_rpt1	318..433	CDD:438989	30/139 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428
		TNG2	<1431..1587	CDD:227367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534
		PHD1_NSD1_2	1545..1587	CDD:277118
		PHD2_NSD1	1592..1638	CDD:277120
		PHD3_NSD1	1639..1692	CDD:277123
		PHD4_NSD1	1709..1748	CDD:277126
		PWWP_NSD1_rpt2	1755..1850	CDD:438992
		AWS	1901..1939	CDD:465559
		SET_NSD1	1941..2082	CDD:380987
		Inhibits enzyme activity in the absence of bound histone	2060..2066
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111
		PHD5_NSD1	2120..2162	CDD:277129
		C5HCH	2161..2210	CDD:465605
		PHA03247	<2208..2574	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696
pdp1	NP_595841.1	PWWP_ScIOC4-like	53..141	CDD:438965	24/95 (25%)
		Med26	293..346	CDD:462573	10/30 (33%)