Protein Alignment NSD1 and Nsd1

DIOPT Version :10

• Sequence 1: NP_071900.2
• Gene: NSD1 / 64324
• HGNCID: 14234
• Length: 2696
• Species: Homo sapiens
• Sequence 2: NP_032765.3
• Gene: Nsd1 / 18193
• MGIID: 1276545
• Length: 2691
• Species: Mus musculus
• Alignment Length: 2701
• Identity: 2261/2701 - (83%)
• Similarity: 2401/2701 - (88%)
• Gaps: 15/2701 - (0%)

Human     1 MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLST-VSGTSQNAYGQD 64
            ||:||||.||||||.|||||||||.|||||||||||||||||||||||||.| .|||||||||||
Mouse     1 MDRTCELSRRNCLLSFSNPVNLDASEDKDSPFGNGQSNFSEPLNGCTMQLPTAASGTSQNAYGQD 65

Human    65 SPSCYIPLRRLQDLASMINVEYLNGSADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAMKQE 129
            |||||||||||||||||||||||:||||||||||||.|||||||:||||||||||||||||||||
Mouse    66 SPSCYIPLRRLQDLASMINVEYLSGSADGSESFQDPAKSDSRAQSPIVCTSLSPGGPTALAMKQE 130

Human   130 PSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCN 194
            |:||||||||::||||.|||||||||||.||||||||||||||||||||||||||||||||||||
Mouse   131 PTCNNSPELQLRVTKTTKNGFLHFENFTGVDDADVDSEMDPEQPVTEDESIEEIFEETQTNATCN 195

Human   195 YETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPLAPQTETQKNKQRNEVDGSNEKAALLPAPFS 259
            ||.||||||:|||||||||.||||||||:.||||||||||.||||||:||||||||.||||||.|
Mouse   196 YEPKSENGVEVAMGSEQDSMPESRHGAVERPFLPLAPQTEKQKNKQRSEVDGSNEKTALLPAPTS 260

Human   260 LGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVG 324
            |||||:|:|||.||||||||||||||.|.||||||:|||||.|||||||||||||||||||||||
Mouse   261 LGDTNVTVEEQFNSINLSFQDDPDSSPSPLGNMLEIPGTSSPSTSQELPFCQPKKKSTPLKYEVG 325

Human   325 DLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGR 389
            |||||||||||||||||||||||||||||||:||||||:|||||||||||:||||||||||||||
Mouse   326 DLIWAKFKRRPWWPCRICSDPLINTHSKMKVANRRPYREYYVEAFGDPSEKAWVAGKAIVMFEGR 390

Human   390 HQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEED 454
            ||||||||||:|||||||||||||||||||||||||||||||||||||||:||:..|:|||||||
Mouse   391 HQFEELPVLRKRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNQKCVSSSVKLDSEED 455

Human   455 MPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFE 519
            ||||||||||:||| |||||||||||||||||||||||||||||.||||||.|||||||..:.||
Mouse   456 MPFEDCTNDPDSEH-LLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKDLVPFE 519

Human   520 AHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFET 584
            :.|:|||||||:||||:||||.:||.||||||||||||||||:||||||||||..:||||.:|||
Mouse   520 SRKEERRGKIPDNLGLDFISGGVSDKQASNELSRIANSLTGSSTAPGSFLFSSSVQNTAKTDFET 584

Human   585 SNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDL 649
            .:.|||.||.|.|||||.|.||.|.|...||.|||:|||:|||||||||:|:|:.||||||.|||
Mouse   585 PDCDSLSGLSESALISKHSGEKKKLQPGQVCSSKVQLCYVGAGDEEKRSNSVSVSTTSDDGCSDL 649

Human   650 DPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMG 714
            ||.||:|...||||.|.||||:|||.||:.||| .:|||:..|| |:|.|||.||:|||.|||||
Mouse   650 DPTEHNSGFQNSVLGITDAFDKTENALSVHKNE-TQYSRYPVTN-RIKEKQKSLITNSHADHLMG 712

Human   715 CTKSAEPGT-ETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALL 778
            .||:.||.| |.|||||||||.|:.:.|||.:|.||.|:.||:....|.:||.|.|||.|||.||
Mouse   713 STKTMEPETAELSQVNLSDLKISSPIPKPQPEFRNDGLTTKFSAPPGIRNENPLTKGGLANQTLL 777

Human   779 HSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMH 843
            ..|.:|||||||||||||:|.:||....:|:.|||||||||.|||||:||||||.:|||||||||
Mouse   778 PLKCRQPKFRSIKCKHKESPAVAETSATSEDLSLKCCSSDTNGSPLANISKSGKGEGLKLLNNMH 842

Human   844 EKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFS 908
            |||||||||||||||||||||||||||||.||||||||:|.||||||||||||||||||||||||
Mouse   843 EKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTAKASKPLLFSSASSQNHIPIEPDYKFS 907

Human   909 TLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQ 973
            |||||||||||||||||||||||||.|||:|.|||||:.||||.|||||.|.||.||||.||.||
Mouse   908 TLLMMLKDMHDSKTKEQRLMTAQNLASYRTPDRGDCSSGSPVGTSKVLVLGSSTPNSEKPGDSTQ 972

Human   974 NSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQM 1038
            :|.:.||.|||||||||||:||..|.||||:|||.||.||:|:.||||||:|||||||:..||||
Mouse   973 DSVHQSPGGGDSALSGELSSSLSSLASDKRELPACGKIRSNCIPRRNCGRAKPSSKLRETISAQM 1037

Human  1039 VKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERG---GSLRGGAEDPSKEDPLQIMGHLTSE 1100
            ||.:||.||||||||||.::||:|||.|...|::|.|   |..|||||||.||:|||.|..|.:|
Mouse  1038 VKPSVNPKALKTERKRKFSRLPAVTLAANRLGNKESGSVNGPSRGGAEDPGKEEPLQQMDLLRNE 1102

Human  1101 DGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQ 1165
            | .||||||||||.|||||.|..||..||||.|||||.|.||:|||||:||||||||||||||||
Mouse  1103 D-THFSDVHFDSKAKQSDPDKNLEKEPSFENRKGPELGSEMNTENDELHGVNQVVPKKRWQRLNQ 1166

Human  1166 RRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSA 1230
            ||.||.||.|||:||||||.||.||||:|.||:.|:::.|.|.|..|..|:...:.||....:|.
Mouse  1167 RRPKPGKRANRFREKENSEGAFGVLLPADAVQKAREDYLEQRAPPTSKPEDSAADPNHGSHSESV 1231

Human  1231 GPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPK 1295
            .||||||:|||..:||:|||.|||||.||.:|||||:||||||||||||||||||||||||||||
Mouse  1232 APRLNVCEKSSVGMGDVEKETGIPSLMPQTKLPEPAIRSEKKRLRKPSKWLLEYTEEYDQIFAPK 1296

Human  1296 KKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSE 1360
            ||||||||||||||||||:||||||.:.||||||||||||||||||||||||||||||||||||:
Mouse  1297 KKQKKVQEQVHKVSSRCEDESLLARCQPSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSD 1361

Human  1361 LGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPK 1425
            ||..||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
Mouse  1362 LGVTHAELPQLTLSVPVAPEASPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPK 1426

Human  1426 KGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDD 1490
            |||||||:||:||....|||.||.|||:.|:|.|||||||||||||||||...|::..||||.:|
Mouse  1427 KGDLGLSRKCFEASRSGNGIVESRATSHLKEFSGGTTKIFDKPRKRKRQRLVTARVHYKKVKKED 1491

Human  1491 SSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGEL 1555
            .:|:.|.|||||:.||||.||||.:||||||||||.||||:|.||||||||||||||||||||||
Mouse  1492 LTKDTPSSEGELLIHRTAASPKEILEEGVEHDPGMSASKKLQVERGGGAALKENVCQNCEKLGEL 1556

Human  1556 LLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECV 1620
            ||||||||||||||||||.||||||||||||.|||||||||||||||||||||||||||||||||
Mouse  1557 LLCEAQCCGAFHLECLGLPEMPRGKFICNECHTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECV 1621

Human  1621 QKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASN 1685
            |||||||.|||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1622 QKYPPTVTQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASN 1686

Human  1686 SIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKA 1750
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1687 SIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKA 1751

Human  1751 GKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPY 1815
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1752 GKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPY 1816

Human  1816 MEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIG 1880
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1817 MEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIG 1881

Human  1881 RVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVE 1945
            ||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||:||
Mouse  1882 RVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGVRCQNQCFSKRQYPDVE 1946

Human  1946 IFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAG 2010
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1947 IFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAG 2011

Human  2011 PKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAP 2075
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  2012 PKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAP 2076

Human  2076 NCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPK 2140
            |||||||||||||||.|||||:|||:|..||||:|||:|||||||||||||||||||||||||||
Mouse  2077 NCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDAGQLVSCKKPGCPK 2141

Human  2141 VYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEH 2205
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Mouse  2142 VYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEH 2206

Human  2206 DPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALA 2270
            |||||||||||||||||||....||.|.|...|||:.||.|.||.||:||.|..|:|.||||||.
Mouse  2207 DPCGPNPLEPGEIREYVPPTATSPPSPGTQPKEQSSEMATQGPKKSDQPPTDATQLLPLSKKALT 2271

Human  2271 GTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSP 2335
            |:||||||||||.|||||....||::|||||||||||||||||||.|||||..|||||..|:.||
Mouse  2272 GSCQRPLLPERPPERTDSSSHLLDRIRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASP 2336

Human  2336 VTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKP 2400
            :|.|||||||.|.||||||...|.|||||||||||:.|::|||...|||||..|||||.|:||||
Mouse  2337 MTRPSSSPSVSSLPLERPLRMTDSRLDKSIGAASPKSQAVEKTPASTGLRLSSPDRLLTTNSPKP 2401

Human  2401 QTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQ 2465
            |.||||.:|.||||:|||||||||||||||:||||||||||||||||||:|.|:|||||||||||
Mouse  2402 QISDRPPEKSHASLTQRLPPPEKVLSAVVQSLVAKEKALRPVDQNTQSKHRPAVVMDLIDLTPRQ 2466

Human  2466 KERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAV 2530
            |||||||.:||||||||..:|||||||:||||||:|||.||..||:.||.|||.|||||.|||||
Mouse  2467 KERAASPQEVTPQADEKTAMLESSSWPSSKGLGHIPRATEKISVSESLQPSGKVAAPSEHPWQAV 2531

Human  2531 KSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAK 2595
            ||||.||.||.|.|||||||..||||||...||||||||.|.:||||||.||:..|     |.||
Mouse  2532 KSLTHARFLSPPSAKAFLYESATQASGRTPVGAEQTPGPPSPAPGLVKQVKQLSRG-----LTAK 2591

Human  2596 SGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQ 2660
            ||||||||||..||||.|||||.|||||||.|||||..||||||||||||||:|||||.||||||
Mouse  2592 SGQSFRSLGKISASLPNEEKKLTTTEQSPWGLGKASPGAGLWPIVAGQTLAQACWSAGGTQTLAQ 2656

Human  2661 TCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK 2696
            |||||||||||||| |.:.||||||||.|||:||:|
Mouse  2657 TCWSLGRGQDPKPE-NAIQALNQAPSSRKCADSEKK 2691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NSD1	NP_071900.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..252		39/44 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..311		25/29 (86%)
		PWWP_NSD1_rpt1	318..433	CDD:438989	110/114 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..514		24/26 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	872..891		15/18 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	936..1035		70/98 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1067..1093		15/28 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1112..1134		14/21 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1243..1272		20/28 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1294..1344		45/49 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1382..1428		45/45 (100%)
		TNG2	<1431..1587	CDD:227367	120/155 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1480..1534		35/53 (66%)
		PHD1_NSD1_2	1545..1587	CDD:277118	40/41 (98%)
		PHD2_NSD1	1592..1638	CDD:277120	43/45 (96%)
		PHD3_NSD1	1639..1692	CDD:277123	52/52 (100%)
		PHD4_NSD1	1709..1748	CDD:277126	38/38 (100%)
		PWWP_NSD1_rpt2	1755..1850	CDD:438992	94/94 (100%)
		AWS	1901..1939	CDD:465559	36/37 (97%)
		SET_NSD1	1941..2082	CDD:380987	139/140 (99%)
		Inhibits enzyme activity in the absence of bound histone	2060..2066		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2091..2111		13/19 (68%)
		PHD5_NSD1	2120..2162	CDD:277129	41/41 (100%)
		C5HCH	2161..2210	CDD:465605	47/48 (98%)
		PHA03247	<2208..2574	CDD:223021	275/365 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2213..2422		148/208 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2464..2499		28/34 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2553..2575		15/21 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2595..2616		17/20 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2665..2696		24/30 (80%)
Nsd1	NP_032765.3	PWWP_NSD1_rpt1	319..434	CDD:438989	110/114 (96%)
		TNG2	<1453..1587	CDD:227367	106/133 (80%)
		PHD1_NSD1_2	1546..1587	CDD:277118	39/40 (98%)
		PHD2_NSD1	1593..1639	CDD:277120	43/45 (96%)
		PHD3_NSD1	1640..1693	CDD:277123	52/52 (100%)
		PHD4_NSD1	1710..1749	CDD:277126	38/38 (100%)
		PWWP_NSD1_rpt2	1756..1851	CDD:438992	94/94 (100%)
		AWS	1902..1940	CDD:465559	36/37 (97%)
		SET_NSD1	1942..2083	CDD:380987	139/140 (99%)
		PHD5_NSD1	2121..2163	CDD:277129	41/41 (100%)
		C5HCH	2162..2211	CDD:465605	47/48 (98%)
		PHA03307	2255..>2576	CDD:223039	244/320 (76%)