DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD1 and mes-4

DIOPT Version :10

Sequence 1:NP_071900.2 Gene:NSD1 / 64324 HGNCID:14234 Length:2696 Species:Homo sapiens
Sequence 2:NP_506333.1 Gene:mes-4 / 179824 WormBaseID:WBGene00003222 Length:898 Species:Caenorhabditis elegans


Alignment Length:1120 Identity:240/1120 - (21%)
Similarity:361/1120 - (32%) Gaps:395/1120 - (35%)


- Green bases have known domain annotations that are detailed below.


Human  1490 DSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGER-----GGGAALKEN----- 1544
            |||||             ..:|::.:.|  :..|..|..||...:|     |.|:....|     
 Worm     7 DSSKE-------------NCAPQDGIVE--KEGPNKPFKKKNVKQRNATPQGAGSETSSNAEDKQ 56

Human  1545 ----VCQNCEKLGELLLCEAQCCGAFHLEC----------LGLTEMPR----------------G 1579
                :..|..|  :::..:.|...||..|.          ...|.:||                |
 Worm    57 EEAPILTNAPK--DIISMQIQETKAFLSEYEEFVDTDYPKTTFTHVPRKFLSVSPFTPIEADAEG 119

Human  1580 KF---------ICNE--CRTGIHTCFVCKQ--SGE--DVKRCL--LPL--CGKFYHEECVQKYPP 1625
            :|         ||:|  .:||......|..  :||  |.||.|  :|:  |...:|..|:..|  
 Worm   120 EFLPDADSKCVICHEEKDKTGKSDLITCHGYINGEMDDGKRLLGNIPMFPCRSKFHASCMINY-- 182

Human  1626 TVMQNKGFR--------------CSLHICITCHAANPANVSASKGRLMRCVRCPVAYHAN----- 1671
               .:.||.              |.||.|.:|:..:... ||..|.:..|..|..|:|..     
 Worm   183 ---NSGGFHFQYAARLECQARLLCPLHCCNSCNLDHHKQ-SAYVGDIAECALCLRAFHLTSCYPS 243

Human  1672 -----DFCLAAGSKILASNSIICPNHF---------------------TPRRGCRNHEHVNVSWC 1710
                 :..:..|.|:.....||||.|:                     .|:.......|:.....
 Worm   244 GGRDLNVSITIGGKVEKFEMIICPAHYLPGADVQFYNKHKKRKNAVTVVPKADVTMKSHIKACCV 308

Human  1711 FVC--SEGGSLLCCDSCPAAFHRECLNID------IPEGNWYCNDCKAGKKPHYREIVWVKVGRY 1767
            ..|  |.....:.|.:|..:||..|..::      ||:..  |..|..|.......::..|....
 Worm   309 IGCEKSSNSKTIMCKTCCRSFHSGCREVETLNGKPIPDDQ--CESCVCGDPIPQNTLILAKWTDN 371

Human  1768 RWWPAEICHPRAVPS------NIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKM 1826
            .:|.|........|:      |.:::.:.|.::  |....||........:.|     ||...::
 Worm   372 SFWLALTLDWYKYPTGNRGNINFERLGYTVVQW--LIPQENDKEKQPLMSIVP-----VSDIARL 429

Human  1827 GKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDK-----KPPPYKHIKVNRPIGRVQIFT 1886
            .|               .:..|.....||.|.|::..::     |..||....|   .||::...
 Worm   430 TK---------------NYFSLAKNSTLRNLWEEKYEEQADTALKRCPYVCKTV---FGRLRTSV 476

Human  1887 ADLSEIPR---------CNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYP 1942
            ....| |:         |||:..|.  | ....|......|||.|: |...|.|.|:..|.....
 Worm   477 YYKCE-PKLEEYHNNEVCNCEGADR--C-TKLSCQYLADDYECPPS-CSKKGVCHNRQVSMGIVS 536

Human  1943 E-VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARI-RYAQEHDI-TNFYMLTLDKD 2004
            | :::..||.:|:|:..|..|:|.|::.|||||:||:.|.:.|: ..:...|. .|.||:.|.|.
 Worm   537 EKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRRLDSVSISRDFQANHYMMELHKG 601

Human  2005 RIIDAGPKGNYARFMNHCCQPNC----------ETQKWSVNGDTRVGLFALSDIKAGTELTFNYN 2059
            ..:||...||.:|::||.|.||.          :|::.|:. |||..:.|:..|..|.|:||:||
 Worm   602 LTVDAARYGNISRYINHSCDPNAASFVTKVFVKKTKEGSLY-DTRSYIRAIRTIDDGDEITFSYN 665

Human  2060 LECLGNGKTV--CKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECF 2122
               :.|.:.:  |:|||.||.|.:|...:.:|...:...|..||.:..|::              
 Worm   666 ---MNNEENLPDCECGAENCMGTMGKAKREKPEVADSSEKAAKKNKSSKKK-------------- 713

Human  2123 SCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHR 2187
                     |.|..           |...:.|||           ...|:...|:.||.      
 Worm   714 ---------SVKNQ-----------NRKSQEAGK-----------NGTASKKSEISPSK------ 741

Human  2188 EGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQA----- 2247
                                                        |||..| .||....||     
 Worm   742 --------------------------------------------PSTSSA-SSTSFVQQASWPIS 761

Human  2248 ------PKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKS 2306
                  .|.|::|.|||...||.|.:.                                      
 Worm   762 QNKKNLKKNSNQPVADTGSTLSTSTEL-------------------------------------- 788

Human  2307 QSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPR 2371
                                 ...:||..:.||.||.|       |...::.||..||    ..|
 Worm   789 ---------------------NFHEKPQELLSPVSSRS-------RAASSSTPRAQKS----KSR 821

Human  2372 PQSLEKTSVPTGLRLPPPDRLLITSSPK----PQTSDRPTDKPHASLSQRLPPPE----KVLSAV 2428
            ...:|..:.|  ::...|....|..:.|    |.|....| |..|..:|.:|.|.    ||.:..
 Worm   822 RDDVESEAPP--VKRATPSLQTIQETGKAIEFPATKSAIT-KARALSTQSVPSPHTVEVKVRAIS 883

Human  2429 VQTLVAKE-KALRPV 2442
            .:..|.|| |...|:
 Worm   884 TRGRVQKETKRFEPI 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSD1NP_071900.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..252
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..311
PWWP_NSD1_rpt1 318..433 CDD:438989
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..514
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..891
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 936..1035
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1134
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1344
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1428
TNG2 <1431..1587 CDD:227367 29/147 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1534 11/43 (26%)
PHD1_NSD1_2 1545..1587 CDD:277118 14/78 (18%)
PHD2_NSD1 1592..1638 CDD:277120 15/67 (22%)
PHD3_NSD1 1639..1692 CDD:277123 15/62 (24%)
PHD4_NSD1 1709..1748 CDD:277126 10/46 (22%)
PWWP_NSD1_rpt2 1755..1850 CDD:438992 14/100 (14%)
AWS 1901..1939 CDD:465559 12/37 (32%)
SET_NSD1 1941..2082 CDD:380987 55/155 (35%)
Inhibits enzyme activity in the absence of bound histone 2060..2066 0/5 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2091..2111 4/19 (21%)
PHD5_NSD1 2120..2162 CDD:277129 6/41 (15%)
C5HCH 2161..2210 CDD:465605 4/48 (8%)
PHA03247 <2208..2574 CDD:223021 50/255 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2422 42/223 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2464..2499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2553..2575
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2595..2616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2665..2696
mes-4NP_506333.1 SET_SETD2-like 538..683 CDD:380929 52/148 (35%)
Blue background indicates that the domain is not in the aligned region.

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