DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NSD1 and nsd1

DIOPT Version :10

Sequence 1:NP_071900.2 Gene:NSD1 / 64324 HGNCID:14234 Length:2696 Species:Homo sapiens
Sequence 2:XP_002936997.3 Gene:nsd1 / 100145675 XenbaseID:XB-GENE-989206 Length:2440 Species:Xenopus tropicalis


Alignment Length:2773 Identity:1098/2773 - (39%)
Similarity:1444/2773 - (52%) Gaps:568/2773 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDQTCELPRRNCLLPFSNPVNLDAPEDKDSPFGNGQSNFSEPLNGCTMQLSTVSGTSQNAYGQDS 65
            ||:.|||   .....:.|.|:   |..|..|. .|.....|..|||::.||:.:.:.:..||||.
 Frog     1 MDEACEL---RSTTDYLNSVD---PNAKSKPC-VGDRGILELPNGCSVPLSSPTQSGKLGYGQDP 58

Human    66 PSCYIPLRRLQDLASMINVEYLNGS----ADGSESFQDPEKSDSRAQTPIVCTSLSPGGPTALAM 126
            .|.||||||||||||||::|.:|||    |:||:  .:|:        |...||..|.|.   |.
 Frog    59 SSHYIPLRRLQDLASMISIEGMNGSQNMEANGSQ--PNPQ--------PYFFTSNEPRGH---AS 110

Human   127 KQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDP----------------EQPVT 175
            .|:.:...|.:|.:| .|.:|||...:::|..||..:.:..::.                :||..
 Frog   111 HQDSTRQFSQDLTMK-PKNVKNGMHPYDSFCHVDMEEPNYAIEQLNYNHTGPGFDVPGYGQQPPV 174

Human   176 EDESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLPL---------AP 231
            |...:.....:::.|.|..:.::.|:.|.:|..|..:...|:.:...|:.||.:         ||
 Frog   175 EQNILPVGENQSKINPTPQFGSELEDLVPLAWSSNGEDPMENENLNTKTSFLSMIRDAEIPNGAP 239

Human   232 QTETQKNKQRNE--------VDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTST 288
            ...|.:|....:        :||.......|.|..: .|.::::||:|:.::...:..||.|   
 Frog   240 INTTPENAIHGDLDHSTILHLDGRLSNQGPLTAEHT-EDESLSVEEELDDLDSHNELSPDRS--- 300

Human   289 LGNMLELPGTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKM 353
                             .|.|...:||...|:|:.||::||||.||||||||||::.......:.
 Frog   301 -----------------GLQFLPRRKKPALLRYDEGDVVWAKFNRRPWWPCRICANSEPEGEPQH 348

Human   354 KVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKIL 418
            |..::|..|.||||..|:.:|:.||..||:|.:.|.||||.||..||..:|::|.:::|||.::|
 Frog   349 KAFSKRLPRNYYVETLGELTEKIWVPAKALVPYRGAHQFEGLPEFRRTQRQEDKSFKNKVPLRLL 413

Human   419 SKWEASVGLAEQYDVPKGSKNRKCIP-GSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFD 482
            |.|::|:..|:.           |:. |:.:.:|.|::                           
 Frog   414 SLWQSSIEHAQD-----------CLSRGAERYESIEEV--------------------------- 440

Human   483 SEHSADEKEKPCAKSRARKSSDNPKRT----------SVKKGHIQFEAHKDERRGKIPENLGLNF 537
                  |..|..|...|::||...|.:          |:.....:.::.|..||.|..::..:..
 Frog   441 ------EGNKQIANYGAKESSGPIKNSFNGFVKSSLCSIDLSCTKTDSKKQHRRLKPVKHRKVEL 499

Human   538 ISGDIS--DTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALIS 600
            ...|:|  |::.:.|              |||..|.|.....:|.....|..:|.:.......:.
 Frog   500 RLSDVSTDDSRTTEE--------------PGSPEFFSSQTCESKFGMAPSQQESCISKQISKEVY 550

Human   601 KCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEI 665
            ..|:|||           |.|    :..:..::|.:               :|.|       |.:
 Frog   551 NISQEKN-----------VTL----SAKKWNKNDEL---------------VEQS-------LGL 578

Human   666 PDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPL-----ISNSHTDHLMGCTKS------- 718
            .....:|:|  ..:|:||      .....:::||||..     :|:...:...|.||.       
 Frog   579 ERTKAQTDN--GQEKSEK------PLMGHKIEAKQKDFRLKQSVSSVQKERSAGTTKKRKRLRIH 635

Human   719 AEPGTETSQVNLSDLKASTLVHKPQSDF-------TNDA------------LSPKF-NLSSSISS 763
            :|....:.::..|.|.:||.| :..::|       |.|.            .||.. |:|.|.|.
 Frog   636 SELSRSSKRLVASSLDSSTNV-ESSNEFSLSKDWVTEDVPDGNGHSVDKNKYSPSLTNVSLSDSC 699

Human   764 ENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPL---- 824
            ||       .:.:||.|.:..|...|||...|.....::..::::..:....|.:...|.|    
 Frog   700 EN-------LHNSLLESNAPSPSQHSIKDFPKALTPESKNCLVHDSATQNSQSKNILDSKLGHKP 757

Human   825 --ASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKP 887
              ||:.|:|:.:.:.||:|||||:.||...||.:|..|:|.|||||.|||.||.::|..||||.|
 Frog   758 AKASLGKTGRPEAMNLLSNMHEKSCDSMKNETKLVNSVISGLKELSSRSLSEDGAESTVSKPSTP 822

Human   888 LLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGV 952
            |||:||..||.||:|||||||.||||||||||:||||::|||.||.||..|....|....||..|
 Frog   823 LLFASAPGQNRIPLEPDYKFSNLLMMLKDMHDTKTKERKLMTGQNTVSSCSDPCEDSIKGSPDIV 887

Human   953 SKV-LVSGGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCV 1016
            ..| .:||..||::|.   |.....|                       ::..|.|:|:::..| 
 Frog   888 PDVGGISGNHTHSNEV---GMVKEPN-----------------------NESKLGATGQNKIVC- 925

Human  1017 TRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGGSLRGG 1081
                  ..|.|||          ||:..:|....|.| |:::.....:.|...........|...
 Frog   926 ------NRKSSSK----------KNSNFQKKPPMEPK-KVSKYKKSMISAQNVNASSECTELTTN 973

Human  1082 AEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSF--ENGKGPELDSVMNSE 1144
            :.:.|    :|:.|...|:...|              |...||.|..:  |.|.|.|..|..:..
 Frog   974 SYNTS----VQLHGECPSKSITH--------------PYNCSEVGAGYPEETGPGSEQSSECSQW 1020

Human  1145 NDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTP 1209
            |:   ....|.||||||::.....:....:......::|.|           ::.:|        
 Frog  1021 NE---SQKYVAPKKRWQKIKHNGPESSTNLLNKASTKSSLC-----------KKEQD-------- 1063

Human  1210 SASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRL 1274
               :||.|...|:|                 ..:.|    ||.:.|:..|.|.|:......||  
 Frog  1064 ---VLEVPKQLQDH-----------------EVTFG----EPELSSIAAQPEAPKRGSNFGKK-- 1102

Human  1275 RKPSKWLLEYTEEYDQIFAPK-KKQKK----VQEQVHK----------VSSRCEEESLLARGRSS 1324
            .|..|.....:.::.:...|| .||||    :|.:|:|          |....|..|   :..||
 Frog  1103 YKKRKRFTRRSGDHVKTSTPKINKQKKLGVSLQLEVNKQKNLKLILPAVDFLSEINS---KATSS 1164

Human  1325 AQNKQVDENSLISTK-----EEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPR 1384
            :|..::.|.....||     |:....|:|...|..|  :..|..|.:|...:|....|.|     
 Frog  1165 SQFSKLAEAYSTETKNPDNEEKSDSSEKEDHGLASP--EQSLSDGFSEPSSITAQSQVNP----- 1222

Human  1385 PALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGL--------SKKCYEAGHL 1441
                     |:     |::|:.|...::.|.:|||.       .|||        :|........
 Frog  1223 ---------VR-----ENRRKSKLIPRVCEFDDLDE-------QLGLLEEDSKPPAKIAKTTSFK 1266

Human  1442 ENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDS-SKEIPGSEGELMPH 1505
            :|.:.:|..      :...:.::.:..|:|||.|.|.   :.||.:|..| ....||.|    ||
 Frog  1267 QNVLKQSFR------YRAASRRLPENRRRRKRIRLAG---KFKKKRNLISRQSSYPGEE----PH 1318

Human  1506 RT-ATSPKETVEEGVEHDPGMPASKKMQGER-GGGAALKENVCQNCEKLGELLLCEAQCCGAFHL 1568
            .. ..|..:|.|||:||:....:.|:.|||| |||||:||||||.|||.||||||||||||||||
 Frog  1319 ENGVASHSDTAEEGLEHELTGASLKRNQGERSGGGAAMKENVCQVCEKPGELLLCEAQCCGAFHL 1383

Human  1569 ECLGLTEMPRGKFICNECRT----GIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQ 1629
            :|||:..||:|||:|.||.:    |.|||||||:|.:.||||:||||||:|||||..||||...|
 Frog  1384 QCLGMEAMPQGKFVCTECSSGTLQGYHTCFVCKESDQGVKRCMLPLCGKYYHEECALKYPPATQQ 1448

Human  1630 NKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFT 1694
            |:|||||||||.||:|.||:|.||||||||||||||||||||||||.||:..|||||||||||||
 Frog  1449 NRGFRCSLHICSTCYATNPSNPSASKGRLMRCVRCPVAYHANDFCLPAGAVTLASNSIICPNHFT 1513

Human  1695 PRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREI 1759
            |||||:||||||||||||||||||||||:||||||||||||||:|||:|:||||||||||||:|:
 Frog  1514 PRRGCKNHEHVNVSWCFVCSEGGSLLCCESCPAAFHRECLNIDMPEGSWFCNDCKAGKKPHYKEV 1578

Human  1760 VWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKD 1824
            ||||||||||||||:|||:.:|.||.||:||:|||||:||||.|||||||||||||||||..:||
 Frog  1579 VWVKVGRYRWWPAEVCHPKTIPPNIQKMKHDIGEFPVVFFGSKDYLWTHQARVFPYMEGDALNKD 1643

Human  1825 KMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADL 1889
            ||.||:|..|||.|.|||.||||||||||:||||||:|||||||||||||||||:|:|||.||||
 Frog  1644 KMSKGMDAVYKKGLMEAAERFEELKAQKEMRQLQEDKKNDKKPPPYKHIKVNRPVGKVQILTADL 1708

Human  1890 SEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGW 1954
            |||||||||||||||||.|||||||||||||||:|||||.|||||.|||||||||||||||.|||
 Frog  1709 SEIPRCNCKATDENPCGQDSECINRMLLYECHPSVCPAGERCQNQAFSKRQYPEVEIFRTLSRGW 1773

Human  1955 GLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFM 2019
            |||.:|||||||||||||||:|||||||||||||||.||||||||||||||:||||||||:||||
 Frog  1774 GLRCRTDIKKGEFVNEYVGEMIDEEECRARIRYAQEQDITNFYMLTLDKDRVIDAGPKGNFARFM 1838

Human  2020 NHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVR 2084
            |||||||||||||:||||||||||||.|||||.||||||||||||||||||||||||||||||||
 Frog  1839 NHCCQPNCETQKWTVNGDTRVGLFALCDIKAGVELTFNYNLECLGNGKTVCKCGAPNCSGFLGVR 1903

Human  2085 PKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNL 2149
            |||||:::|:|.|  |:||..||: :.|:.||.|||||||||.|||||||||||||||||:||.|
 Frog  1904 PKNQPVSSEDKGK--KRKQYVKRK-KSEVVKEHEDECFSCGDGGQLVSCKKPGCPKVYHAECLKL 1965

Human  2150 TKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLE 2214
            |:||||||||||||||||.|||||.||||||||||||||||||||||||||||||||||||:|||
 Frog  1966 TRRPAGKWECPWHQCDICHKEAASLCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPHPLE 2030

Human  2215 PGEIREY---------VPPPVP--------------------------LPPGPST-------HLA 2237
            |||||||         ..|.:|                          :...|:|       :::
 Frog  2031 PGEIREYDSSNEQNDSAGPSLPKKKTLDSAKGKTASSNSHKKNVSVTEVLHTPTTAGSTSSGNVS 2095

Human  2238 EQSTGMAAQAPKMSDK-PPADTNQMLSLSKKALAGTCQRPLLPERPLERTD--SRPQPLDKVRDL 2299
            :::.|...|....:.| ..|...|..:...|.|..:..:..||...:..|.  .:..|..||. |
 Frog  2096 KENVGSVEQKSLSAGKILLASAGQKCTTGSKLLLASAIQKSLPAGKVVLTSLGKKSLPAGKVL-L 2159

Human  2300 AGSGTKSQS-------------------LVSSQRPLDRPP-----AVAG---------------- 2324
            |..|.|..|                   ::|:......|.     |.||                
 Frog  2160 ASIGKKQLSAGKVLVTSLGKNSPSVGRMIISTAGKHSLPAGKVLLASAGKYTTAGKVLLTSATNQ 2224

Human  2325 ---PRPQLSDKPSPV--TSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGL 2384
               .....:||.:.|  |..|..|..:.:..::||.  .|..|| :.....:|.:...|   ||:
 Frog  2225 HSTAEKNKADKQNDVKETQNSLDPDTKHRITKKPLN--KPSKDK-LNTTLEQPLTQNHT---TGI 2283

Human  2385 RLP-------PPDRLLITSSP-KPQTSDRPTDKPHASL---SQRLPPPEKVLSA---VVQTLVAK 2435
            :.|       .|....:|..| ||:...:|..:.|..:   ...:|...:.|||   ..|....|
 Frog  2284 QKPVSPCQVERPSNPSLTGRPEKPKDKHQPDSEVHPKILLKRSTMPTSRRSLSAHKERFQISTKK 2348

Human  2436 EKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHM 2500
            |.:|    :::|.:|.|....|  ..:|..||:.::|      ::..:..:||.|.||:      
 Frog  2349 EGSL----ESSQVENHATPRKD--SCSPTVKEKPSAP------SERSLSTVESPSIPAA------ 2395

Human  2501 PRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPP 2543
            |.......:|..|.:|.|..:.||   .::.|:.|.:..|..|
 Frog  2396 PENSSGRAISCTLASSEKTVSTSE---MSLSSVVQEKTSSTEP 2435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NSD1NP_071900.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..252 11/61 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 281..311 5/29 (17%)
PWWP_NSD1_rpt1 318..433 CDD:438989 51/114 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..514 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 872..891 11/18 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 936..1035 21/99 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1093 2/25 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1134 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1272 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1344 19/69 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1428 8/45 (18%)
TNG2 <1431..1587 CDD:227367 71/166 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1534 18/55 (33%)
PHD1_NSD1_2 1545..1587 CDD:277118 32/41 (78%)
PHD2_NSD1 1592..1638 CDD:277120 33/45 (73%)
PHD3_NSD1 1639..1692 CDD:277123 43/52 (83%)
PHD4_NSD1 1709..1748 CDD:277126 34/38 (89%)
PWWP_NSD1_rpt2 1755..1850 CDD:438992 72/94 (77%)
AWS 1901..1939 CDD:465559 33/37 (89%)
SET_NSD1 1941..2082 CDD:380987 130/140 (93%)
Inhibits enzyme activity in the absence of bound histone 2060..2066 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2091..2111 8/19 (42%)
PHD5_NSD1 2120..2162 CDD:277129 37/41 (90%)
C5HCH 2161..2210 CDD:465605 46/48 (96%)
PHA03247 <2208..2574 CDD:223021 95/440 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2422 60/309 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2464..2499 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2553..2575
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2595..2616
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2665..2696
nsd1XP_002936997.3 PWWP_NSD1_rpt1 314..428 CDD:438989 52/124 (42%)
PHD1_NSD1_2 1360..1402 CDD:277118 32/41 (78%)
PHD2_NSD1 1411..1457 CDD:277120 33/45 (73%)
PHD3_NSD1 1458..1511 CDD:277123 43/52 (83%)
PHD4_NSD1 1528..1567 CDD:277126 34/38 (89%)
PWWP_NSD1_rpt2 1574..1669 CDD:438992 72/94 (77%)
AWS 1720..1758 CDD:465559 33/37 (89%)
SET_NSD1 1760..1901 CDD:380987 130/140 (93%)
PHD5_NSD1 1936..1978 CDD:277129 37/41 (90%)
C5HCH 1977..2026 CDD:465605 46/48 (96%)
PTZ00449 <2209..>2434 CDD:185628 54/251 (22%)
Blue background indicates that the domain is not in the aligned region.

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