Protein Alignment SOX17 and Sox15

DIOPT Version :10

• Sequence 1: NP_071899.1
• Gene: SOX17 / 64321
• HGNCID: 18122
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 147/528 - (27%)
• Similarity: 189/528 - (35%)
• Gaps: 173/528 - (32%)

Human     1 MSSPDAGYASDDQSQTQ---SALPAVMAGL----------GP-CPWAESLSPI-GDMKVKGEAPA 50
            :|.|.||.......|.:   |..|...|.:          .| |.:.|...|: .|:|.:
  Fly   142 LSHPHAGMVGGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYR----- 201

Human    51 NSGAPAGAAGRAKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKR 115
                |.|...::..||||||||||||||||.|||:||.:|||||||:|||||||.|::||..::|
  Fly   202 ----PGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRR 262

Human   116 PFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALGPEGGRVAMDGLG 180
            |:|||||||||.||.:|||||||||||||.|......||.....:.|.
  Fly   263 PYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPN----------------- 310

Human   181 LQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPL----DGYPLPTPDTSPLDGVDPDPAFFAAPM 241
                            |..||. :....|..|||    ..|..|| |.|..:..:.:   .....
  Fly   311 ----------------PGTGGS-KSNPKLATPPLATASSSYTTPT-DESTCNSTNQN---HGQST 354

Human   242 PG---DCPAAGTYSYAQVSDYAG--------------PP------EPPAG-------------PM 270
            ||   :.|...|||.:.|..|:.              ||      .|..|             |.
  Fly   355 PGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPS 419

Human   271 HPRL----------------GPEPAGPSIPGL------LAPPSALHVYYGAMGSPGAGGGRGFQM 313
            ..|.                |.:..|.|..|:      |||.|...|  .|.|.......||..
  Fly   420 PSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVV--AARGMYVTCNNRGLL- 481

Human   314 QPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTD---------PSQPAELLGEVDRTEFEQYL-- 367
              .|.|..:...:|  |...|....:...|:...         .|.|:...|.:..:|...|.
  Fly   482 --DHGHSVKGTFYP--PVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVS 542

Human   368 -------------------------HFVCKPEMGLPYQGHDSGVNLPDSHGAI--SSVVSDASSA 405
                                     .:..:.|..|.||.:|    :..|..|:  ....||::|.
  Fly   543 MADNCGNLRLSMNELSGNEYLPSANAYGMQYEDFLRYQSND----MDYSTSAVEHKETTSDSASG 603

Human   406 VYYCNYPD 413
            .....|||
  Fly   604 QKCLKYPD 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..66		5/30 (17%)
		HMG-box_SoxF_SOX17	62..142	CDD:438850	60/79 (76%)
		Sox17_18_mid	203..253	CDD:463454	14/56 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..286		11/78 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..352		9/55 (16%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	361..369		2/34 (6%)
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	58/74 (78%)
		PHA03273	305..>391	CDD:223031	21/123 (17%)