DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SRSF7 and CBC2

DIOPT Version :9

Sequence 1:	NP_001026854.1	Gene:	SRSF7 / 6432	HGNCID:	10789	Length:	238	Species:	Homo sapiens
Sequence 2:	NP_015147.1	Gene:	CBC2 / 855925	SGDID:	S000006099	Length:	208	Species:	Saccharomyces cerevisiae

Alignment Length:	150	Identity:	29/150 - (19%)
Similarity:	57/150 - (38%)	Gaps:	42/150 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    13 VYVGNLGTGAGKGELERAFSYYGPLRTVWIARN-----PPGFAFVEFEDPRDAEDAVRGLDGKVI 72
            :|||||.....:.::...||..|.::.:.:..:     |.||.|:.:..|.:|.:|::.|....:
Yeast    48 IYVGNLSFYTSEEQIYELFSKCGTIKRIIMGLDRFKFTPCGFCFIIYSCPDEALNALKYLSDTKL 112

Human    73 CGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKG-------HYAYDCHR--------- 121
            ....:.::|..|.....:|.|                |:.|       .:.:|..|
Yeast   113 DEKTITIDLDPGFEDGRQFGR----------------GKSGGQVSDELRFDFDASRGGFAIPFAE 161

Human   122 -----YSRRRRSRSRSRSHS 136
                 :||...|.|:|.:::
Yeast   162 RVGVPHSRFDNSSSQSNTNN 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRSF7	NP_001026854.1	RRM_SRSF7	12..88	CDD:410050	18/79 (23%)
		Sufficient for interaction with NXF1	81..98		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..238		5/13 (38%)
		6 X 8 AA repeats of R-R-S-R-S-X-S-X	153..226
CBC2	NP_015147.1	RRM	<1..>159	CDD:223796	24/126 (19%)
CBC2	NP_015147.1	RRM_NCBP2	48..125	CDD:409686	17/76 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910