Protein Alignment SRSF6 and SF2

DIOPT Version :10

• Sequence 1: NP_006266.2
• Gene: SRSF6 / 6431
• HGNCID: 10788
• Length: 344
• Species: Homo sapiens
• Sequence 2: NP_652611.1
• Gene: SF2 / 53443
• FlyBaseID: FBgn0283477
• Length: 255
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 112/286 - (39%)
• Similarity: 145/286 - (50%)
• Gaps: 57/286 - (19%)

Human     3 RVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYG----FVEFEDSRDADDAVYELNGKELCGE 63
            |:|:|.|..::|.||||..|..:|::..|||||..|    ||||||:|||||||...:|.:..|.
  Fly     8 RIYVGNLPPDIRTKDIQDLFHKFGKVTFVDLKNRRGPPFAFVEFEDARDADDAVKARDGYDYDGY 72

Human    64 RVIVEHAR---------GPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPV-RTEYRLIVENLS 118
            |:.||..|         |.|.||      ||.|||     |..||   |||. |::||::|..|.
  Fly    73 RLRVEFPRGGGPGSYRGGNRNDR------SRDGGG-----RMGGR---GPPAKRSQYRVMVTGLP 123

Human   119 SRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRN-----IRL 178
            :..|||||||.||:||:|.:||.:|:  ..||:||..:.|||.|:.|||.:......     ||:
  Fly   124 ASGSWQDLKDHMREAGDVCFADTYKD--GSGVVEFLRHEDMKYAIKKLDDSRFRSHEGEVAYIRV 186

Human   179 IEDKPRTSHRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKS 243
            .||          ||...|......|......|....||.. :.||||||.|   ||.|.:|..:
  Fly   187 RED----------SGDNDRGGGGGGSGGGGGGSGGGGSRDY-RDRSRSRSFS---SRPRRRGTPT 237

Human   244 RSKSKSKPKSDRGSHSHSRSRSKDEY 269
            .|..:.:        |:|||||:..|
  Fly   238 YSPVRRQ--------SYSRSRSRSNY 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF6	NP_006266.2	RRM1_SRSF6	1..72	CDD:410009	36/81 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..103		10/27 (37%)
		RRM2_SRSF6	110..182	CDD:410159	33/76 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..344		30/94 (32%)
SF2	NP_652611.1	RRM_SF	3..80	CDD:473069	35/71 (49%)
		RRM2_SRSF1_like	115..188	CDD:410013	32/74 (43%)