DRSC/TRiP Functional Genomics Resources

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Protein Alignment SRSF6 and Rox8

DIOPT Version :10

Sequence 1:NP_006266.2 Gene:SRSF6 / 6431 HGNCID:10788 Length:344 Species:Homo sapiens
Sequence 2:NP_732944.2 Gene:Rox8 / 42848 FlyBaseID:FBgn0005649 Length:470 Species:Drosophila melanogaster


Alignment Length:202 Identity:40/202 - (19%)
Similarity:77/202 - (38%) Gaps:38/202 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     4 VYIGRLSYNVREKDIQRFFSGYGRLLEVDL--------KNGYGFVEFEDSRDADDAVYELNGKEL 60
            :::|.||..:..:.::..|:.:|.:....:        ..||.||.|....:|::|:..:||:.:
  Fly    97 IFVGDLSPEIETETLREAFAPFGEISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWI 161

Human    61 CGERVI-----VEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKY---------GPPVRTEY- 110
             |.|.|     ......||....|...|...|||..:.....|..::         .|...|.| 
  Fly   162 -GSRSIRTNWSTRKLPPPREPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYC 225

Human   111 -----RLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTE 170
                 .:|.::|..       |.|: |.|.:......|:: ....|:|.:......|::....:|
  Fly   226 GGFPPNVISDDLMH-------KHFV-QFGPIQDVRVFKDK-GFSFIKFVTKEAAAHAIEHTHNSE 281

Human   171 INGRNIR 177
            ::|..::
  Fly   282 VHGNLVK 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SRSF6NP_006266.2 RRM1_SRSF6 1..72 CDD:410009 17/80 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..103 6/36 (17%)
RRM2_SRSF6 110..182 CDD:410159 13/74 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..344 0/2 (0%)
Rox8NP_732944.2 RRM1_TIA1_like 9..80 CDD:409788
RRM2_TIA1_like 96..170 CDD:409789 17/73 (23%)
RRM_SF 221..292 CDD:473069 14/77 (18%)
Blue background indicates that the domain is not in the aligned region.

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