DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SRSF6 and Rox8

DIOPT Version :9

Sequence 1:	NP_006266.2	Gene:	SRSF6 / 6431	HGNCID:	10788	Length:	344	Species:	Homo sapiens
Sequence 2:	NP_001262897.1	Gene:	Rox8 / 42848	FlyBaseID:	FBgn0005649	Length:	470	Species:	Drosophila melanogaster

Alignment Length:	202	Identity:	40/202 - (19%)
Similarity:	77/202 - (38%)	Gaps:	38/202 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     4 VYIGRLSYNVREKDIQRFFSGYGRLLEVDL--------KNGYGFVEFEDSRDADDAVYELNGKEL 60
            :::|.||..:..:.::..|:.:|.:....:        ..||.||.|....:|::|:..:||:.:
  Fly    97 IFVGDLSPEIETETLREAFAPFGEISNCRIVRDPHTMKSKGYAFVSFVKKAEAENAIQAMNGQWI 161

Human    61 CGERVI-----VEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKY---------GPPVRTEY- 110
             |.|.|     ......||....|...|...|||..:.....|..::         .|...|.|
  Fly   162 -GSRSIRTNWSTRKLPPPREPSKGGGQGGGMGGGPGNGSGVKGSQRHTFEEVYNQSSPTNTTVYC 225

Human   111 -----RLIVENLSSRCSWQDLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTE 170
                 .:|.::|..       |.|: |.|.:......|:: ....|:|.:......|::....:|
  Fly   226 GGFPPNVISDDLMH-------KHFV-QFGPIQDVRVFKDK-GFSFIKFVTKEAAAHAIEHTHNSE 281

Human   171 INGRNIR 177
            ::|..::
  Fly   282 VHGNLVK 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRSF6	NP_006266.2	RRM1_SRSF6	1..72	CDD:410009	17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..103		6/36 (17%)
		RRM2_SRSF6	110..182	CDD:410159	13/74 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..344		0/2 (0%)
Rox8	NP_001262897.1	ELAV_HUD_SF	5..274	CDD:273741	37/186 (20%)
		RRM1_TIA1_like	9..80	CDD:240798
		RRM2_TIA1_like	96..170	CDD:240799	17/73 (23%)
		RRM3_TIA1_like	221..294	CDD:240800	14/77 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900