DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CXCR5 and Rh6

DIOPT Version :9

Sequence 1:	NP_001707.1	Gene:	CXCR5 / 643	HGNCID:	1060	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	78/361 - (21%)
Similarity:	147/361 - (40%)	Gaps:	87/361 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    55 PVAYSLI-FLLGVI------GNVLVLVILERHRQTRSSTETFLFHLAVADLLLVF-ILPFAVAEG 111
            |:.:.:| |::.::      ||.:|:.|....:..|:.:..|:.:||.:|.:::| :.|..|..|
  Fly    44 PMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNG 108

Human   112 SVG-WVLGTFLCKTVIALHKVNFYCSSL-LLACIAVDRYLAIVH--------AVHAYRHRRLLSI 166
            ..| |::|.|||: :..:....|.|.|: .:..||.|||..||.        |..|.  .||:.:
  Fly   109 FYGTWIMGPFLCE-LYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAV--LRLMVV 170

Human   167 HITCGTIW----LVGFLLALPEILFAKVSQGHHNNSLPRC---TFSQENQAETHAWFTSRFL--Y 222
            ...||. |    |.|:...:||            .::..|   .|:::       |:...::  |
  Fly   171 WTICGA-WALMPLFGWNRYVPE------------GNMTACGTDYFAKD-------WWNRSYIIVY 215

Human   223 HVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQ----------------------KAVRVAILVT 265
            .:..:|.|:|.:.:.|..::..:...::..:.|                      |..:||:...
  Fly   216 SLWVYLTPLLTIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTI 280

Human   266 SIFFLCWSPYHIVIFLDTL--ARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVK 328
            |::|..|:||.|:.:....  ..|..:...|   ||:         ...|:...||::|..:..|
  Fly   281 SLWFFAWTPYTIINYAGIFESMHLSPLSTIC---GSV---------FAKANAVCNPIVYGLSHPK 333

Human   329 FRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESE 364
            ::..|...:..|.| |...|.....:...:.:|||:
  Fly   334 YKQVLREKMPCLAC-GKDDLTSDSRTQATAEISESQ 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CXCR5	NP_001707.1	7tm_1	68..322	CDD:278431	65/297 (22%)
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	69/324 (21%)
		TM helix 1	50..74	CDD:320207	6/23 (26%)
		TM helix 2	83..105	CDD:320207	6/21 (29%)
		TM helix 3	121..143	CDD:320207	4/22 (18%)
		TM helix 4	165..181	CDD:320207	5/16 (31%)
		TM helix 5	209..232	CDD:320207	4/22 (18%)
		TM helix 6	273..295	CDD:320207	8/21 (38%)
		TM helix 7	306..331	CDD:320207	7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910