Protein Alignment CXCR5 and npr-8

DIOPT Version :9

• Sequence 1: NP_001707.1
• Gene: CXCR5 / 643
• HGNCID: 1060
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_741834.1
• Gene: npr-8 / 183869
• WormBaseID: WBGene00016984
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 485
• Identity: 94/485 - (19%)
• Similarity: 173/485 - (35%)
• Gaps: 152/485 - (31%)

Human     8 EMDLENLEDLFWELDRLDNYNDTSL---VENHLCPATEGPLMASF--------------KAVFVP 55
            :.|:|:| .:..|:..:|||.|..:   ..|:|....:|..:..|              :.:...
 Worm    11 DTDIEDL-GMIMEVKDIDNYCDRGISPNASNYLTYPFDGLCLQKFFYQLQTSLRRFTPYEEIIYT 74

Human    56 VAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFI-LPFAVAEGSVGWV--- 116
            ..|.:|.:..||||.||::.:.|.:..|::....:.:||:::|:|... :||.       |:
 Worm    75 TVYIIISVAAVIGNGLVIMAVVRKKTMRTNRNVLILNLALSNLILAITNIPFL-------WLPSI 132

Human   117 -----LGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLV 176
                 ...|.||....|...|.|||:|.::.:|:|||.::.....|...::.....:....||:|
 Worm   133 DFEFPYSRFFCKFANVLPGSNIYCSTLTISVMAIDRYYSVKKLKIASNRKQCFHAVLVSLAIWIV 197

Human   177 GFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSR---------------------- 219
            .|:|:||.:|:.:.|..:....:.....|.:....::.|...|
 Worm   198 SFILSLPLLLYYETSMLYVMREIRVVDQSGQEVIRSYGWRQCRLVSAGRLPDITQSIQLLMSILQ 262

Human   220 --FLYHVAGFLLPMLVMGWCYVGVVHRLRQ----------------------------------- 247
              |||     ::|:.|:....|.:...|:.
 Worm   263 VAFLY-----IVPLFVLSIFNVKLTRFLKTNANKMSKTRAPPKRFDRSDSHHNSLKNNNNHTSSL 322

Human   248 ------------AQRRPQRQKAVRVAILVTSI---FFLCWSPYHIVIFL---------DTLARLK 288
                        .:|....|:..|...|:.::   :...|.|:.::.||         |.:..::
 Worm   323 RSPSMPSIRSSITERNKTNQRTNRTTSLLIAMAGSYAALWFPFTLITFLIDFELIINQDYVNLVE 387

Human   289 AVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTK-LGCTGPASLCQLF 352
            .:|.|||:...|.:             |:||.||.|....||.:.|.:..: :.|...:.
 Worm   388 RIDQTCKMVSMLSI-------------CVNPFLYGFLNTNFRHEFSDIYYRYIRCETKSQ----- 434

Human   353 PSWR-----------RSSLSESENATSLTT 371
            |:.|           |.....::.||.|||
 Worm   435 PAGRFHHDVSSIAHHRQDSVYNDEATLLTT 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CXCR5	NP_001707.1	7tm_1	68..322	CDD:278431	63/345 (18%)
npr-8	NP_741834.1	7tmA_NPYR-like	82..419	CDD:320331	70/361 (19%)
		TM helix 2	106..128	CDD:320331	6/28 (21%)
		TM helix 3	144..166	CDD:320331	7/21 (33%)
		TM helix 4	189..205	CDD:320331	6/15 (40%)
		TM helix 5	256..279	CDD:320331	5/27 (19%)
		TM helix 6	345..370	CDD:320331	4/24 (17%)
		TM helix 7	387..412	CDD:320331	11/37 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I4779
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910