DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CXCR5 and npr-25

DIOPT Version :9

Sequence 1:	NP_001707.1	Gene:	CXCR5 / 643	HGNCID:	1060	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_505883.1	Gene:	npr-25 / 179570	WormBaseID:	WBGene00011381	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	103/368 - (27%)
Similarity:	154/368 - (41%)	Gaps:	74/368 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    44 PLM-ASFKAVFVPVAYSLIFLLGVIGNVLVL-VILERHRQTRSST----ETFLFHLAV--ADLLL 100
            ||: |||....:|  ||:.|:.|.:||..|| .:....|..:||.    .||::.:|:  .|||:
Worm    14 PLVGASFAKTAIP--YSICFVFGTLGNTAVLSYVFFITRSLKSSVTALGNTFIYIVALCAVDLLV 76

Human   101 VFILPFAVAEGSV-GWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVH----AVHAYRH 160
            ...:||:::...: .||.|..:||....|...|..||:.:|..:|.|||:||.|    .:|..||
Worm    77 TVSIPFSLSYMILNNWVFGELVCKIHFMLELSNKMCSTFILTALAFDRYMAICHPEIKRIHEMRH 141

Human   161 RRLLSIHITCGTIWLVGFLLALPEILFAK----------VSQGHHNNSLPRCTFSQENQAETHAW 215
                :|:||.....|..||:: |.:|.|:          ||..:..:.:.|.........|...|
Worm   142 ----TIYITTILATLSLFLIS-PVVLSARVTSFKSGQYFVSAKNERHEVIRQMCIDGMALEWKVW 201

Human   216 FTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAV---RVAI--LVTSIFFL-C--- 271
             .|.||...| ||||..::.:.|..:|.|||: |||...|..:   |:.|  :..:.|:| |
Worm   202 -VSAFLIFFA-FLLPCTLLTYFYAKIVLRLRR-QRRTMLQSRIPLRRITIYTMAATFFYLSCHIP 263

Human   272 -WSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDL-- 333
             |.|....||...|..        |:|..:.........|.......|.:.|.....:|:..|
Worm   264 FWLPQIYNIFSTVLGH--------KMNPKVMTFTYYSHLLPFISAAFNWIFYARLNSQFKKGLVL 320

Human   334 --SRLLTKLGCTGPASLCQLFPSWRRSSLSE---SENATSLTT 371
              .|::.|                |..|:.|   ||.|..||:
Worm   321 VTERMIRK----------------RTKSMHEKGYSEAAVELTS 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CXCR5	NP_001707.1	7tm_1	68..322	CDD:278431	80/285 (28%)
npr-25	NP_505883.1	7tm_classA_rhodopsin-like	24..311	CDD:381740	86/304 (28%)
		TM helix 1	24..48	CDD:381740	9/25 (36%)
		TM helix 2	63..84	CDD:381740	7/20 (35%)
		TM helix 3	100..122	CDD:381740	6/21 (29%)
		TM helix 4	144..160	CDD:381740	5/16 (31%)
		TM helix 5	200..223	CDD:381740	9/24 (38%)
		TM helix 6	244..269	CDD:381740	7/24 (29%)
		TM helix 7	286..311	CDD:381740	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910