Protein Alignment SRSF4 and Saf-B

DIOPT Version :10

• Sequence 1: NP_005617.2
• Gene: SRSF4 / 6429
• HGNCID: 10786
• Length: 494
• Species: Homo sapiens
• Sequence 2: NP_733041.2
• Gene: Saf-B / 42958
• FlyBaseID: FBgn0039229
• Length: 928
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 140/564 - (24%)
• Similarity: 203/564 - (35%)
• Gaps: 165/564 - (29%)

Human    80 GSGRS-GYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADA-----HKG 138
            |||.| |.|...:..:|....:|   .|.|..||:.....|||....:.|:|..|..     ..|
  Fly   290 GSGSSAGNGTGANSNNKQATLSR---NLWVSGLSTLTRASDLKAIFSKFGKVIGAKVVTNTRTPG 351

Human   139 RKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDK-------------------PGSRRRR- 183
            .:..|.:...|.:|..|.:|.|..||::||.|.:...|                   .|::::.
  Fly   352 TRCYGYVTMSSSADASRCIENLHRTELHGRIISVERTKNEIGGSLNSKEGKGKAPGDAGNKKKED 416

Human   184 -SYSRSRSHSRSRSRSRHSRKSRSRSGSSKS--------SHSKSRSRSRSGSRSRSKSRSRSQSR 239
             |..:|.|...|.|.|...:|....:|.|||        ....:|:|||... .|.||.: ||.|
  Fly   417 DSGKKSGSGKGSSSNSGDDKKGGDGNGDSKSVGGDLKRDGKESNRARSRRND-DRGKSLA-SQDR 479

Human   240 SRSKKEKS----------RSP--------SKEKSRSRSHSAGKSRSKSKDQAE-EKIQNNDNVGK 285
            .|..:|:|          |:|        .:::.|.|......|..|.:::.| ::::..:.
  Fly   480 PRHDRERSAKGSQDHRSGRNPRDVDREIQQRQRERERRQREMLSYQKIREERERQRLRERER--- 541

Human   286 PKSRSPSRHKSKSKSRSRSQERRVEEEKRG-SVSRGR-SQEKS--LRQSRSR------------- 333
             :.|...|.:.:::.|.|.:|.|::||:|. :|.|.| .:||:  ||..|.|
  Fly   542 -ELREEERRRREARERQRIEEERLQEERRKLAVERERLEREKAELLRMERERQKLEREKIELERL 605

Human   334 -----------SRSKGGSRSRSRSRSKSKDKRKG----RKRS---------REESR---SRSR-- 369
                       ||...|    .|..||..|.|.|    |||:         |.::.   |||.
  Fly   606 ELKRQQMKIMESRDDPG----KRGVSKRADDRYGDVTDRKRTAIFDAPPPPRFDTNLVSSRSTYD 666

Human   370 -------SRSKSER-------SRKR---GSKRDSKAGSSKKKK-----------KEDTDRSQSRS 406
                   |.|.::|       |.||   .|||:..:.||..|:           |...|.|.|.|
  Fly   667 KKHDDYGSSSSTKRVLDDYSSSSKRLDYSSKRNDYSSSSGSKRGAVDDYTAVPTKRSNDYSASSS 731

Human   407 PSRSVSKEREHAKSESSQREGRGESEN-----------AGT----NQETRSRSRSNSKSKPNLPS 456
            ..|...|..|......|...|.|.|.:           ||:    |..:.:..|.|...:.|..|
  Fly   732 SKRDDYKRDEVRHLPLSGTVGGGSSSSYLHKNNTAGGGAGSYVHKNNTSGTGGRYNDSDRSNTSS 796

Human   457 ESRSRSKSASKTRSRSKSRSRSASRS---------PSRSRSRSH 491
            ..|..|.|....|..:.|....|..|         ||...|.||
  Fly   797 YRRDDSHSLGNKRYDNSSGGGGAYGSSSNSVNIWAPSSGGSSSH 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF4	NP_005617.2	RRM1_SRSF4	1..87	CDD:410007	5/7 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..95		6/15 (40%)
		RRM2_SRSF4_like	104..175	CDD:410012	22/75 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..494		111/469 (24%)
Saf-B	NP_733041.2	SAP	11..42	CDD:460424
		2A1904	<16..>270	CDD:273344
		RRM_SF	311..386	CDD:473069	23/77 (30%)
		SWIRM-assoc_1	<588..618	CDD:465142	2/29 (7%)