DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SRSF4 and nito

DIOPT Version :9

Sequence 1:	NP_005617.2	Gene:	SRSF4 / 6429	HGNCID:	10786	Length:	494	Species:	Homo sapiens
Sequence 2:	NP_001286174.1	Gene:	nito / 35756	FlyBaseID:	FBgn0027548	Length:	793	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	78/345 - (22%)
Similarity:	124/345 - (35%)	Gaps:	103/345 - (29%)

- Green bases have known domain annotations that are detailed below.

Human     4 VYIGRLSYQARERDVERFFKGYGKILEVDLK-------NGYGFVEFDDLRDADDAVYELNGKDLC 61
            ::.|.|.....:.::.|.|..||.:.::|:|       |.:.||.:.:|..|..|..||:|:.:
  Fly   316 LFAGNLEVTIADDELRRIFGKYGVVDDIDIKRPPPGTGNAFAFVRYQNLDMAHRAKIELSGQYI- 379

Human    62 GERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQ 126
                           |.: ..:.|||       |..|.|    |:.:..|.:..|...|:....:
  Fly   380 ---------------GKF-QCKIGYG-------KVTPAT----RMWIGGLGAWTSVTQLEREFDR 417

Human   127 AGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVED---KPGS--------- 179
            .|.:...:..|| :....|::.:......|::::.|..:.|.:.||..|   .||:
  Fly   418 FGAIKKIEYQKG-EPYAYIQYETVEAATAAVKEMRGFPLGGPERRLRTDFAELPGATPAAPFKSS 481

Human   180 -----------RR---------------RRSYS--------RSRSHSRSRSRSR---HSRKSR-- 205
                       ||               |..||        |.|...|.|.|..   |:...|
  Fly   482 KPPYDESALEYRRPEYDPYYEESAAYAPRGGYSPYPPRGGYRGRGGYRGRGRGMYHYHNDVHRPP 546

Human   206 ---SRSGSSKS-----------SHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSR 256
               |.:|||.|           ......|..| |:||.|:.....:|||||..:::|||..:...
  Fly   547 HPGSLAGSSSSVPPPGGVEDEWRRPPGESYDR-GARSSSREPGVERSRSRSPLKRARSPGSDSDT 610

Human   257 S-RSHSAGKSRSKSKDQAEE 275
            | |.:.|..|.|...|.|.:
  Fly   611 STRRNDALASASTVPDVARK 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SRSF4	NP_005617.2	RRM1_SRSF4_like	3..72	CDD:240783	17/74 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..95		4/22 (18%)
		RRM2_SRSF4_like	104..175	CDD:241044	13/70 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..494		43/173 (25%)
nito	NP_001286174.1	RRM	<56..>223	CDD:223796
		RRM1_Spen	98..175	CDD:240754
		RRM2_Spen	312..390	CDD:240755	21/97 (22%)
		RRM3_Spen	397..467	CDD:240756	13/70 (19%)
		SPOC	630..789	CDD:311609	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910