DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGEF28 and RhoGEF2

DIOPT Version :10

Sequence 1:NP_001073948.2 Gene:ARHGEF28 / 64283 HGNCID:30322 Length:1731 Species:Homo sapiens
Sequence 2:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster


Alignment Length:1941 Identity:366/1941 - (18%)
Similarity:619/1941 - (31%) Gaps:682/1941 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   278 LVKAFEPEARPEERTAMPSSGAETEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLD 342
            |.:|..|:....::..:|||   |:....|:.|.||        ::|:..:...:...|..|.::
  Fly   628 LDRATSPQLNRSQQQQLPSS---TDNSPSNAKSKRS--------KIKTKALSDPKMSTQMFLQME 681

Human   343 R---------SFDILKKSKPPSTLLAAGRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITA 398
            .         |.:: ....||......|.:::.::.|     :|..:.|...:..:: |...::.
  Fly   682 SASAAGAAGGSIEV-DGGPPPLPPRLPGMMTEDMSRG-----SCQNLAQPNSVGTAF-NYPLVST 739

Human   399 TTSPESRGCTLWPQSSKHTLPTETSPSVYPLSEN---VEGTAHTEAQQSFMSPSSSCASNL---- 456
            ||:.::....:                .:|||:.   |:.....:.||............|    
  Fly   740 TTAVQNDNLNI----------------AFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTP 788

Human   457 NLSFGWH---GFEKEQSH-------LKKRSSSLDALDADSEGEGHSEP-------SHIC------ 498
            ||....|   |...:..|       .|..|.|.:.::.|.|......|       ||:.      
  Fly   789 NLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPN 853

Human   499 -------------------YTPGSQSSSRTGI----------PSGD---ELDSFE-TNTEPD--- 527
                               :||.:.:||...|          .|.|   |:.|.| .|::.|   
  Fly   854 ENNRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDENSDLDEPF 918

Human   528 ------FN---------------------ISRAESLPLSSNLQS---KESLLSGVRSRSYSCSS- 561
                  ||                     ||.::..||...|.:   ||.....:|..:|...| 
  Fly   919 IDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHST 983

Human   562 ---PKISLGKTR----LVREL---------------TVCSSSEEQRAYSLSEPPRE--------- 595
               |:..|...|    |.||:               ||...|.::....:||..||         
  Fly   984 FLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQKRTAGL 1048

Human   596 ----------------NRIQEEEWDKYIIP---AKSESE---------KYKVSRTFSFLMNRM-- 630
                            ::::|:..|||::|   |..|.|         |..:....|.::.|:  
  Fly  1049 GTIYGPTDDKLAEAKTDKLREQIIDKYLMPNLHALIEDENGSPPEDVRKVALCSALSTVIYRIFN 1113

Human   631 TSP--------------RNKS-KTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLG--KES 678
            |.|              |:|| |::......|..:..|......:..|..|..|...:.|  .:.
  Fly  1114 TRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQYYEVTHCNHCQTIIWGVSPQG 1178

Human   679 LQCSNCNANVHKGCK----DAAP---------ACTKKFQEKYNKNKPQT--ILGN---------- 718
            ..|::|..|:|:.|.    ::.|         |...|..:...|.:|:|  ::||          
  Fly  1179 YHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKIRPRTSDVIGNEKRSRQDEEL 1243

Human   719 -----------------------------------------------SSF-----RDIPQPG--- 728
                                                           |||     .|...||   
  Fly  1244 DVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFHGSCANDSINPGGGA 1308

Human   729 ----------LSLHPSS--SVPVGLPT-------------GRRETVGQVHPLSRSVPGTT--LES 766
                      .|..||:  ||..||..             .|||...| ||..:|.|.:.  .||
  Fly  1309 GCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRERYSQ-HPKHKSAPVSVNRSES 1372

Human   767 F------RRSATSLESESDHNSCRSRSHSDEL----------------LQSMG--SSPST----- 802
            :      :|:..|....|| .|..||.:.::|                |.|.|  .||||     
  Fly  1373 YKERLSNKRNRNSRRKTSD-PSLSSRPNDEQLDLGLSNATYVGSSNSSLSSAGGSESPSTSMEHF 1436

Human   803 ------------------------------ESFIMEDVVDSSL---------------------- 815
                                          :.:..:|...:.|                      
  Fly  1437 AAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGHPLP 1501

Human   816 ---WSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRK 877
               |:..|.|..:.....||.:|.............|||::|.|:.|||.:|::||.::..:|..
  Fly  1502 VARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFL 1566

Human   878 GMKEE--LQLDHSTVDKIF-PCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQF 939
            .:.|.  |..||..:  :| |.|..|.|||..|..|:|:||.|      .|.|::.|||:|...|
  Fly  1567 PLYESGLLSQDHLLL--LFPPALLSLREIHGAFEQSLKQRRIE------HNHVVNTIGDLLADMF 1623

Human   940 SEENASKMKKIYGEFCCHHKEAVNLFKELQQNK--KFQNFIKLRNSNLLARRRGIPECILLVTQR 1002
            ..::...:.:...:||...:.|:...|| ::||  ..|..:|...|:...||..:.:.:..|.||
  Fly  1624 DGQSGVVLCEFAAQFCARQQIALEALKE-KRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQR 1687

Human  1003 ITKYPVLVERILQYT----KERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIEN 1063
            :||||:|.|.:.:.|    .|.|.|.:.:::|:...|.::..|:..|...|...|...|..|::.
  Fly  1688 LTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDR 1752

Human  1064 KTYTKLKNGHVFRKQALMSEERTLLYDG-LVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIF- 1126
            .:|.|    ..|:|..|  .:..|::|| |...|..:   ..:..||..::::.|.::|.||.. 
  Fly  1753 SSYDK----EEFKKLDL--TQHHLIHDGNLTIKKNPS---VQLHGLLFENMIVLLTKQDDKYYLK 1808

Human  1127 -----AAVDQKP--SVISLQ-KLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRI 1183
                 .::..||  .::|:. ..:.|:.|.::...|||...::  :|.|:...|..|...|.:..
  Fly  1809 NLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTS--QMLELRAPSSSECKTWFKHF 1871

Human  1184 QQAVESCPEEKGGRTSESDEDKRKAEARVAKI-----QQCQEILTNQDQQICAYLEEKLHIYAEL 1243
            .. |.:...:...:.:.|:.|...::..:|.|     ::..|:.|:..|.:.|           .
  Fly  1872 SD-VAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAA-----------T 1924

Human  1244 GELSGFEDVHLEPHLLIKPDPGEPPQAASLL------------AAALKEAESLQVAVKASQMGAV 1296
            ..|:......:.|...:.|.|.......|.|            .|:..:|:.:......|....|
  Fly  1925 ATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEV 1989

Human  1297 SQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCS---------DVDPGIQGVVTDLAV 1352
            ::             |:|.... |.|.......|.|....:         .|.||..|...:...
  Fly  1990 NR-------------TMSIRST-GEPIQKYSANGTEANDVTLRHSQSTRESVRPGSTGEERNSTY 2040

Human  1353 SDAG-------EKVECRNFPGSSQSEIIQA-IQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEG 1409
            ...|       ..:.|.|...::::.::|: :.:.|.:..|:..|.|.:.        ||...|.
  Fly  2041 GMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEP--------VLTPGEK 2097

Human  1410 LSLGHSILRGGPLQDQK-----SRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRE 1469
            |....:.:|...|:.||     .|.....::::.::..:....:......|...:|.|       
  Fly  2098 LRRLDASIRNDLLEKQKIICDIFRLPVEHYDQIVDIAMMPEAPKDSADIALAAYDQIQ------- 2155

Human  1470 SWLQERERECQSQEELLLRSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHG 1534
                                  .|...|.||.|           |..||.......::.||. |.
  Fly  2156 ----------------------TLTKMLNEYMH-----------VTPEQEVSAVSTAVCGHC-HE 2186

Human  1535 RQR------------SLPAVLLPGG----------------PEVMELNRSESLCHENS---FFIN 1568
            :::            |.|..|.|..                |::..|:..|...||:.   ..|:
  Fly  2187 KEKLRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQIPPSRLMPKLQTLDLDEVAIHEDDDGYCEID 2251

Human  1569 EALVQ--------------MSFNTFNKLNPSVIH-----------------------------QD 1590
            |..:.              ..|||..|.:.|||.                             :|
  Fly  2252 ELRLPAIPSKPHERPTTPLAPFNTEPKTSQSVIDASKRQSTDAVPEGLLEQEPLEGDKTETKGED 2316

Human  1591 ATYPTTQS--------------HSDLVR------TSEHQVDLKVD--PSQPSNVSHKLWTAAGSG 1633
            ....|..|              .:|:.:      ||:::....||  |||    |.::.||..:.
  Fly  2317 NEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKNEAAASVDELPSQ----SREIKTAENAS 2377

Human  1634 HQILPFHESSKDSCKNGSSMTKCSCTLTSPPGLWTGTTSTLKDLDTSHTESPTPHD 1689
            ..:....|.::::.:.|.:.|..|.|.|||                  ||||...|
  Fly  2378 KSVADKKEDNEETIEEGVASTVDSSTQTSP------------------TESPKETD 2415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGEF28NP_001073948.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..316 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..524 18/96 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 630..649 7/35 (20%)
C1_p190RhoGEF 646..706 CDD:410426 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..800 38/207 (18%)
RhoGEF 853..1042 CDD:214619 60/197 (30%)
PH_p190RhoGEF 1087..1187 CDD:275430 24/109 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1187..1207 3/19 (16%)
Interaction with PTK2/FAK1, required for regulation of axonal branching and synapse formation. /evidence=ECO:0000250 1295..1304 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1312..1339 6/35 (17%)
Mediates cytoplasmic retention and interaction with YWHAH. /evidence=ECO:0000250 1372..1383 2/11 (18%)
RNA-binding. /evidence=ECO:0000250 1496..1527 7/30 (23%)
Mediates cytoplasmic retention and interaction with MAPK8IP1. /evidence=ECO:0000250 1566..1579 4/26 (15%)
RhoGEF2NP_477317.1 PDZ_ARHGEF11-12-like 258..333 CDD:467282
RGS_GEF_like 934..1055 CDD:188710 23/120 (19%)
C1_ARHGEF-like 1150..1202 CDD:410382 10/51 (20%)
RhoGEF 1539..1731 CDD:238091 62/200 (31%)
PH_16 1756..1876 CDD:436083 29/131 (22%)
Blue background indicates that the domain is not in the aligned region.

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