Protein Alignment SRSF1 and rump

DIOPT Version :10

• Sequence 1: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Sequence 2: NP_649899.1
• Gene: rump / 41138
• FlyBaseID: FBgn0267790
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 256
• Identity: 66/256 - (25%)
• Similarity: 95/256 - (37%)
• Gaps: 86/256 - (33%)

Human     3 GGGVIRGPAG--NNDCRIYVGNLPPDIRTKDIEDVFYK-YGAIRDIDL------KNRRGGPPFAF 58
            ||||......  ..:||:|:.|:|.|.|.:|::|:|.: .|:|..:.|      |.|..|    .
  Fly    42 GGGVAARDRSRERRNCRVYISNIPYDYRWQDLKDLFRRIVGSIEYVQLFFDESGKARGCG----I 102

Human    59 VEFEDPRDAEDAVYGRDGYDYDGYRLRVE------------FPRSGRGTGRGGGG---------G 102
            |||:||.:.:.|:...:.|:.:|..|.|:            ..|.|.|.|.||||         |
  Fly   103 VEFKDPENVQKALEKMNRYEVNGRELVVKEDHGEQRDQYGRIVRDGGGGGGGGGGVQGGNGGNNG 167

Human   103 GGGGAPR-------------------GR------------------YGPPSRRSE---------N 121
            ||||..|                   ||                  ||..:...|         |
  Fly   168 GGGGGGRDHMDDRDRGFSRRDDDRLSGRNNFNMMSNDYNNSSNYNLYGLSASFLESLGISGPLHN 232

Human   122 RVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRD------GTGVVEFVRKEDMTYAVRKLD 176
            :|.|:.|......:.||...:.||.|...|:..|      |..|:|:....:...|:..||
  Fly   233 KVFVANLDYKVDNKKLKQVFKLAGKVQSVDLSLDKEGNSRGFAVIEYDHPVEAVQAISMLD 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	26/98 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		23/100 (23%)
		RRM2_SRSF1	113..196	CDD:410160	19/79 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248
		Interaction with SAFB1	198..247
rump	NP_649899.1	PABP-1234	48..435	CDD:130689	62/250 (25%)
		RRM1_hnRNPM_like	58..133	CDD:409819	25/78 (32%)
		RRM2_hnRNPM_like	234..307	CDD:409820	16/60 (27%)
		RRM_SF	565..629	CDD:473069