Protein Alignment SRSF1 and Rsf1

DIOPT Version :10

• Sequence 1: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Sequence 2: NP_477001.2
• Gene: Rsf1 / 34370
• FlyBaseID: FBgn0011305
• Length: 200
• Species: Drosophila melanogaster
• Alignment Length: 238
• Identity: 82/238 - (34%)
• Similarity: 105/238 - (44%)
• Gaps: 66/238 - (27%)

Human     1 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPP-FAFVEFEDP 64
            ||..|..||      .|:|||||...::..|:|..|.|||.:..:.:   ...|| |||||||..
  Fly     1 MSSMGDQRG------TRVYVGNLTDKVKKDDLEGEFTKYGKLNSVWI---AFNPPGFAFVEFEHR 56

Human    65 RDAEDAVYGRDGYDYDGYRLRVEF----PRSG-------RGTGRG---------GGGGGGGGAPR 109
            .|||.|....:|.:..|.:||||.    ||.|       ||..||         ||.||||...|
  Fly    57 DDAEKACDILNGSELLGSQLRVEISKGRPRQGRRGGPMDRGGRRGDFGRHSITSGGSGGGGFRQR 121

Human   110 GRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRK 174
            |..|..||.:| |...||...:.|:..     ||.|          |:|   |.|:|  .|...:
  Fly   122 GSSGSSSRHTE-RGYSSGRSGASSYNG-----REGG----------GSG---FNRRE--VYGGGR 165

Human   175 LDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRS 217
             |::::.|  |.:|            ||||:..:|..|.||||
  Fly   166 -DSSRYSS--GSSA------------SYGRTGGQSAGRFRSRS 193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	31/82 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		22/65 (34%)
		RRM2_SRSF1	113..196	CDD:410160	21/82 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		10/27 (37%)
		Interaction with SAFB1	198..247		10/20 (50%)
Rsf1	NP_477001.2	RRM_SRSF3_like	11..82	CDD:409808	31/73 (42%)