Protein Alignment SRSF1 and Hrb27C

DIOPT Version :10

• Sequence 1: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Sequence 2: NP_476869.1
• Gene: Hrb27C / 33968
• FlyBaseID: FBgn0004838
• Length: 421
• Species: Drosophila melanogaster
• Alignment Length: 207
• Identity: 45/207 - (21%)
• Similarity: 82/207 - (39%)
• Gaps: 43/207 - (20%)

Human    17 RIYVGNLPPDIRTKDIEDVFYKYGAIRD-IDLKNRRGGPP--FAFVEFEDPRDA----EDAVYGR 74
            :::||.|..:...:::...|.::|.|.| :.:||...|..  |.||.|.||.:.    ::..:..
  Fly     8 KLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQNGPHTL 72

Human    75 DGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKD 139
            ||...|.....   ||:.:...:|||                    .:|.:.|||.:.:..||:.
  Fly    73 DGRTIDPKPCN---PRTLQKPKKGGG--------------------YKVFLGGLPSNVTETDLRT 114

Human   140 HMREAGDVCYADVYRD-------GTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGP 197
            .....|.|....:..|       |.|.:.|..:.    :|..:.|.::.:..|:  .:.:|...|
  Fly   115 FFNRYGKVTEVVIMYDQEKKKSRGFGFLSFEEES----SVEHVTNERYINLNGK--QVEIKKAEP 173

Human   198 RSPSYGRSRSRS 209
            |..|.|::.:.|
  Fly   174 RDGSGGQNSNNS 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	19/79 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		9/45 (20%)
		RRM2_SRSF1	113..196	CDD:410160	16/89 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		6/19 (32%)
		Interaction with SAFB1	198..247		4/12 (33%)
Hrb27C	NP_476869.1	RRM1_hnRNPA_hnRNPD_like	9..80	CDD:409763	19/70 (27%)
		RRM2_DAZAP1	94..173	CDD:409765	18/104 (17%)