Protein Alignment SRSF1 and srp2

DIOPT Version :10

• Sequence 1: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Sequence 2: NP_594570.1
• Gene: srp2 / 2542772
• PomBaseID: SPAC16.02C
• Length: 365
• Species: Schizosaccharomyces pombe
• Alignment Length: 243
• Identity: 86/243 - (35%)
• Similarity: 114/243 - (46%)
• Gaps: 25/243 - (10%)

Human    14 NDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYD 78
            ::.|::||.:||....:|:.|.|..||.|.|..|.|     .|.|||.||.|||.|.|....|.:
pombe     2 SETRLFVGRIPPQATREDMMDFFKGYGQILDCKLMN-----GFGFVEVEDARDARDIVNDFQGKE 61

Human    79 YDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMRE 143
            :.|.|:.||..|..|..............||      .||:..|::|..|....|||||||.||:
pombe    62 FMGSRIVVEPARGERRRRENFRESAASKYPR------PRRTGFRLIVENLSEDVSWQDLKDVMRK 120

Human   144 AGDVCYADVYRD--GTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDG-----PRSPS 201
            ||:..:.|.:|:  |.|||||..:|||..|:..|:....:   |:...:|...|.     |..||
pombe   121 AGEPTFTDAHRENPGAGVVEFSTEEDMRNALTSLNGEVIK---GQAVTLREDPDAANEPLPEVPS 182

Human   202 YGRSRS---RSRSRSRSRSRSNSRSRSYSPRRSRGSPRYSPRHSRSRS 246
            ..||||   |.|.|...|...:.|..:|.|.|. ...||:||....|:
pombe   183 RFRSRSPPARRRYRDDYRRGGDYRRDAYRPGRD-DERRYAPRGEYRRN 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	30/75 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		9/45 (20%)
		RRM2_SRSF1	113..196	CDD:410160	31/84 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		22/64 (34%)
		Interaction with SAFB1	198..247		19/52 (37%)
srp2	NP_594570.1	RRM_SF	5..69	CDD:473069	28/68 (41%)
		RRM2_SRSF1_4_like	98..167	CDD:409776	28/71 (39%)
		PRK12678	<211..>307	CDD:237171	7/20 (35%)