Protein Alignment SRSF1 and rsp-3

DIOPT Version :10

• Sequence 1: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Sequence 2: NP_001370111.1
• Gene: rsp-3 / 176688
• WormBaseID: WBGene00004700
• Length: 258
• Species: Caenorhabditis elegans
• Alignment Length: 256
• Identity: 154/256 - (60%)
• Similarity: 176/256 - (68%)
• Gaps: 38/256 - (14%)

Human     8 RGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVY 72
            ||  |:.|.::||||||.|:|.|::||:|:|||.|:.:|:|:.| ||.||||||||.|||||||.
 Worm     3 RG--GSEDQKVYVGNLPGDVREKEVEDIFHKYGRIKYVDIKSGR-GPAFAFVEFEDHRDAEDAVR 64

Human    73 GRDGYDYDGYRLRVEFPRSGRGTGRGG----------GGGGGGGAPRGRYGPPSRRSENRVVVSG 127
            .||||::||.|:||||.|.....|.||          ||...||...||.|.|.||:..||:|.|
 Worm    65 ARDGYEFDGRRIRVEFTRGVGPRGPGGRPLQDGGDHRGGDFRGGRGGGRGGGPQRRTGYRVIVEG 129

Human   128 LPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRV 192
            |||:|||||||||||:|||||||||.|||||||||.|.||:.|||||||:|||||||||||||||
 Worm   130 LPPTGSWQDLKDHMRDAGDVCYADVARDGTGVVEFTRYEDVKYAVRKLDDTKFRSHEGETAYIRV 194

Human   193 KVD------------------GPR-----SPSYG--RSRSRSRSRSRSRSRSNSRSRSYSP 228
            :.|                  .||     ||.|.  ||||||||||||||||.|||.|.||
 Worm   195 REDNSSGGGSGGGGRDRSRSRSPRAERRASPKYSPRRSRSRSRSRSRSRSRSASRSPSRSP 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	49/77 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		23/55 (42%)
		RRM2_SRSF1	113..196	CDD:410160	66/100 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		30/63 (48%)
		Interaction with SAFB1	198..247		26/38 (68%)
rsp-3	NP_001370111.1	RRM1_SRSF1_like	10..80	CDD:409775	45/70 (64%)
		RRM2_SRSF1_like	123..196	CDD:410013	61/72 (85%)