DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SFRP5 and fz

DIOPT Version :9

Sequence 1:	NP_003006.2	Gene:	SFRP5 / 6425	HGNCID:	10779	Length:	317	Species:	Homo sapiens
Sequence 2:	NP_001261836.1	Gene:	fz / 45307	FlyBaseID:	FBgn0001085	Length:	612	Species:	Drosophila melanogaster

Alignment Length:	229	Identity:	72/229 - (31%)
Similarity:	101/229 - (44%)	Gaps:	40/229 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     6 AGGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKR 70
            :|||:..::...|.|..|  ..|||                          |..:.:|..:.|..
  Fly    32 SGGGLMASSGTELDGLPH--HNRCE--------------------------PITISICKNIPYNM 68

Human    71 MRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC--LDRPIYPCRSLCEAVRA 133
            ..:|||:.|....|...:...:.||:...|..|.|:|||||:.|||  |:|||.|||||||:.|.
  Fly    69 TIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARV 133

Human   134 GCAPLMEAYGFPWPEMLHCHKFPL--DNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQ 196
             |..||:.|.|.|||.|.|.|||:  ..|||:|.......:||...|:..|:........|:...
  Fly   134 -CEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVESP 197

Human   197 MCSSDFVVKMRIK-------EIKIENGDRKLIGA 223
            ..:..||..:::|       |:|:...|....||
  Fly   198 HRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGA 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SFRP5	NP_003006.2	CRD_SFRP5	47..173	CDD:143553	50/129 (39%)
SFRP5	NP_003006.2	NTR_Sfrp1_like	178..303	CDD:239635	11/53 (21%)
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	53/142 (37%)
fz	NP_001261836.1	Frizzled	237..564	CDD:279827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810