Protein Alignment ABCG8 and w

DIOPT Version :10

• Sequence 1: NP_071882.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_476787.1
• Gene: w / 31271
• FlyBaseID: FBgn0003996
• Length: 687
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 180/599 - (30%)
• Similarity: 294/599 - (49%)
• Gaps: 54/599 - (9%)

Human    88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGG--KIKSGQIWINGQPSSPQLVRKCVAH 150
            ::|:......|::||::||||.|:.:||:.:..|...|  ...||...:||||...:.::...|:
  Fly   113 LKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAY 177

Human   151 VRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVG-NMYVRGLS 214
            |:|.:..:.:||.||.|.|.|.:|:||..:..||..||:.||.||.|.:|..|.:| ...|:|||
  Fly   178 VQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLS 242

Human   215 GGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRL 279
            ||||:|::...:.|.:|.:||.|||||||||||||::|:.|.:|::..:.|::::|||.|::|.|
  Fly   243 GGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFEL 307

Human   280 FDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQS 344
            ||.:|||..|...:||.....|.:|:.:|..||...|||||||.:.::   ...:|:.:|::...
  Fly   308 FDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAV---VPGREIESRDRIAK 369

Human   345 LAALF-LEKV-RDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSP----TKMPGAVQQFTTLI 403
            :...| :.|| ||::..|   .||:|::         ||:     .|    |.......||..::
  Fly   370 ICDNFAISKVARDMEQLL---ATKNLEK---------PLE-----QPENGYTYKATWFMQFRAVL 417

Human   404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVI 468
            .|...:..::...:.:...:..::::.||.::.|....|:..|:....:|:....:.|..:...|
  Fly   418 WRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATI 482

Human   469 SKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFL 533
            :...||..:...|....||....||..|.:.|||......:::....|.:..||.|    :|||
  Fly   483 NVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAG----VLHF- 542

Human   534 LVWLVVFCCRIMALAAAALLPTF-----------HMASFFSNALYNSFYLAGGFMINLSSLWTVP 587
                  |.|..:....|.:..:|           .||......:...|.|.|||.:|..|:....
  Fly   543 ------FNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYL 601

Human   588 AWISKVSFLRWCFEGLMKIQFS---RRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIG 649
            .|:|.:|:.|:..|||:..|::   .........|.|...||..||..:...:..|...|:.:..
  Fly   602 KWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAI 666

Human   650 LSGGFMVLYYVSLR 663
            |...|.||.|::||
  Fly   667 LIVSFRVLAYLALR 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCG8	NP_071882.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		ABCG_White	60..295	CDD:213201	86/209 (41%)
		3a01204	88..663	CDD:273361	178/597 (30%)
w	NP_476787.1	3a01204	68..687	CDD:273361	180/599 (30%)