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Protein Alignment ABCG8 and abcg8

DIOPT Version :10

Sequence 1:	NP_071882.1	Gene:	ABCG8 / 64241	HGNCID:	13887	Length:	673	Species:	Homo sapiens
Sequence 2:	NP_001108041.3	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	676	Species:	Danio rerio

Alignment Length:	656	Identity:	403/656 - (61%)
Similarity:	511/656 - (77%)	Gaps:	9/656 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    24 QDRLFSS-ESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELG 87
            :|.|||| |.|:||||||||..|.||||:|||:||.|:|:||:|:|::|||||...|.:.:.
Zfish    24 RDILFSSPEEDSSLYFTYSGGRNELEVRNLNYEVDTAAQIPWYEKLSEFKMPWEMHSNKQTV--- 85

Human    88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVR 152
            |::|:..|.||||||:|||||||:.||||:||.|..||.:.||:|.|||:||:..||:|.:||||
Zfish    86 IKDLNLHVHSGQMLAVIGSSGCGKTSLLDIITCRDEGGSMNSGEILINGKPSTRSLVKKSIAHVR 150

Human   153 QHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGE 217
            |.::|||:|||||||||:|::|||..|||.|||:||:||||||||||||.|||||.||||:||||
Zfish   151 QDDRLLPHLTVRETLAFVAKLRLPANFSQKQRDQRVDDVIAELRLRQCAHTRVGNEYVRGVSGGE 215

Human   218 RRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDL 282
            ||||||.||||||||||||||||||||||||||||.||.|||:||||||:|:||||||||:||||
Zfish   216 RRRVSIAVQLLWNPGILILDEPTSGLDSFTAHNLVITLYRLARGNRLVLLSVHQPRSDIFQLFDL 280

Human   283 VLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAA 347
            |:|::||:.:|.|.|:.||.|||.:|||||||.||:|:||||.|||||:.|:|....|||..|||
Zfish   281 VVLLSSGSAVYCGQAKDMVSYFTTLGYPCPRYCNPSDYYVDLISIDRRTPEKEAQCLEKASMLAA 345

Human   348 LFLEKVRDLDDFLWKAET---KDLDEDTCVESSVTPLDTNCLPSPTK--MPGAVQQFTTLIRRQI 407
            .|||||::.:||:||:|.   ..|:.......||:..::....|..|  :||.|.|||||||||:
Zfish   346 QFLEKVKNNEDFMWKSEVCGPPALEAPQSSVPSVSMKESVITVSKQKDQLPGKVHQFTTLIRRQV 410

Human   408 SNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCY 472
            .||:|||.||::||.||.|||:.|||||||.....||..||.|||:|||||.||.|:||||:||:
Zfish   411 FNDYRDLVTLVVHGLEALLMSLLIGFLYFGCTEEGLSIQDTVALLYMIGALTPFAVVLDVIAKCH 475

Human   473 SERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWL 537
            |||||||:|||||:|:..||||||:|||||||||:.::||:|.||||.|......|||:||||||
Zfish   476 SERAMLYHELEDGMYSVTPYFFAKVLGELPEHCAFTLVYGVPIYWLAGLNVAPDRFLLNFLLVWL 540

Human   538 VVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEG 602
            .|:|.|.|||..||.|||...:||..|||:..|||..||:|:|.::|.|.:|.|.:||:||.|||
Zfish   541 TVYCSRSMALFVAAALPTLQTSSFMGNALFTVFYLTAGFVISLENMWMVASWFSYISFMRWGFEG 605

Human   603 LMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQ 667
            ::::||......:.:||||:...|.|::.:|:::.|||::.||::|.:|..|::|||:||:||||
Zfish   606 MLQVQFRGTRIPITIGNLTVEFDGIKVVEMMKMNQYPLFSCYLVLIAVSLVFILLYYLSLKFIKQ 670

Human   668 KPSQDW 673
            |.||||
Zfish   671 KSSQDW 676

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.