DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SFRP4 and fz2

DIOPT Version :9

Sequence 1:	NP_003005.2	Gene:	SFRP4 / 6424	HGNCID:	10778	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	142	Identity:	57/142 - (40%)
Similarity:	82/142 - (57%)	Gaps:	24/142 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    24 CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLE 88
            ||.:.|||||.:.:|:|..||.::|.||:.|.|.:.|:..||::.||..|:||||:||.||| ||
  Fly    64 CEEITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC-LE 127

Human    89 FLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWI 153
            ..|.|:..|:|||:|||..|.|:|:.|:..|||.:||:.||::.
  Fly   128 DYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHG--------------------- 171

Human   154 DITPDMMVQERP 165
              .||.:..|:|
  Fly   172 --DPDNLCMEQP 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SFRP4	NP_003005.2	CRD_FZ	20..146	CDD:321937	53/121 (44%)
		NTR_like	188..296	CDD:321963
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..346
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	57/142 (40%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141197
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11309
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840