DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SFRP4 and Corin

DIOPT Version :9

Sequence 1:	NP_003005.2	Gene:	SFRP4 / 6424	HGNCID:	10778	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	197	Identity:	50/197 - (25%)
Similarity:	75/197 - (38%)	Gaps:	45/197 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    16 ALGVRGAP--CEAVRIPMCR--HMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFF 76
            :.|...||  |..:.:..|:  .:|:|.|..||::.|..|......::.||.||||.|..::..|
  Fly   769 SFGKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLF 833

Human    77 LCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEA 141
            ||.::.|.|.......|  |||::|......|.....::..|.||.|.|               .
  Fly   834 LCTLFVPKCGQSGATVP--PCKTLCTETMRRCGFFFDVFGLSLPEYLNC---------------K 881

Human   142 IVTDLP--EDVKWIDITPDMM-------------------VQERPLD--VDCKRLSPDRCKCKKV 183
            :..|.|  ||...:|...::|                   .||...|  :||.. ..|..||::.
  Fly   882 LFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMD-QADEAKCERC 945

Human   184 KP 185
            .|
  Fly   946 GP 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SFRP4	NP_003005.2	CRD_FZ	20..146	CDD:321937	34/129 (26%)
		NTR_like	188..296	CDD:321963
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..346
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	36/132 (27%)
		LDLa	911..942	CDD:238060	6/31 (19%)
		LDLa	945..979	CDD:238060	1/3 (33%)
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810