DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SFRP2 and fz2

DIOPT Version :9

Sequence 1:	NP_003004.1	Gene:	SFRP2 / 6423	HGNCID:	10777	Length:	295	Species:	Homo sapiens
Sequence 2:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	139	Identity:	49/139 - (35%)
Similarity:	69/139 - (49%)	Gaps:	20/139 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    40 CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEV-LEQAGAWIPLVMKQCHPDTKKFLCSLFAPVC 103
            |:.|  .:.:|.||.|.....||.:.|||..|. ||....| |||..:|.||.|.||||::.|:|
  Fly    64 CEEI--TIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFW-PLVEIKCSPDLKFFLCSMYTPIC 125

Human   104 LDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDND---LCIPLASSDHLLPAT 165
            |:|..:.:..|.|:|.:.:..|||:|..:.|.||:.:.|:..|...|   ||:
  Fly   126 LEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCM------------ 178

Human   166 EEAPKVCEA 174
             |.|...||
  Fly   179 -EQPSYTEA 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SFRP2	NP_003004.1	CRD_SFRP2	36..163	CDD:143555	45/126 (36%)
SFRP2	NP_003004.1	NTR_Sfrp1_like	169..295	CDD:239635	3/6 (50%)
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	46/133 (35%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810