DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SFRP2 and Corin

DIOPT Version :9

Sequence 1:	NP_003004.1	Gene:	SFRP2 / 6423	HGNCID:	10777	Length:	295	Species:	Homo sapiens
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	169	Identity:	44/169 - (26%)
Similarity:	62/169 - (36%)	Gaps:	39/169 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    43 IPANLQLCHG--IEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLD 105
            :|..::.|.|  |.|.....||.:||....|......::..||..:|:.....|||:||.|.| .
  Fly   780 LPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC-G 843

Human   106 DLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDML------------------------------ 140
            ....|:.||.:||.:...||......||...|:.|
  Fly   844 QSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHP 908

Human   141 ECDRFPQDNDLCIP--LASSDHL--LPATEEAPKVCEAC 175
            :||.|..|.:.|:|  .....||  :...:||.  ||.|
  Fly   909 KCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAK--CERC 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SFRP2	NP_003004.1	CRD_SFRP2	36..163	CDD:143555	39/155 (25%)
SFRP2	NP_003004.1	NTR_Sfrp1_like	169..295	CDD:239635	3/7 (43%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	31/114 (27%)
		LDLa	911..942	CDD:238060	9/32 (28%)
		LDLa	945..979	CDD:238060	1/1 (100%)
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810