DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATL2 and atl2

DIOPT Version :9

Sequence 1:	NP_001317392.1	Gene:	ATL2 / 64225	HGNCID:	24047	Length:	584	Species:	Homo sapiens
Sequence 2:	NP_001103492.1	Gene:	atl2 / 323665	ZFINID:	ZDB-GENE-030131-6505	Length:	599	Species:	Danio rerio

Alignment Length:	580	Identity:	400/580 - (68%)
Similarity:	473/580 - (81%)	Gaps:	23/580 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     5 DEAARGQQ--PHQGLWRRRRTSDPSAAVNHVSSTT------SLGENYEDDDLVNSDEVMKKPCPV 61
            ||...|.|  |   :|....|   .:.:...||.|      ::.|..|    :..|.|.:...|:
Zfish    23 DEDMTGVQDVP---IWSPAET---LSTLEEFSSDTNGVAPCAVAEELE----LEEDPVPEGARPI 77

Human    62 QIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSW 126
            |||:.:|:||.||||..|||:||||||::|||:||||||||||||||||||||||||:::.::||
Zfish    78 QIVITNENDHKFELDAAALEKILLQEHVKDLNVVVVSVAGAFRKGKSFLLDFMLRYMHDQSAESW 142

Human   127 IGGNNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVLLMDTQGAFDSQSTIKDCATVF 191
            |||::||||||:|||||||||||||.|:||||:::.:||||||||:|||||||||||||||||||
Zfish   143 IGGDDEPLTGFSWRGGCERETTGIQAWSEVFVVEKKDGTKVAVLLVDTQGAFDSQSTIKDCATVF 207

Human   192 ALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGL 256
            |||||||||||||||||||||||||||||||||||||||||:||||.|:||||||.|||||.|||
Zfish   208 ALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYEKPFQKLLFLIRDWCYPYEHDYGL 272

Human   257 EGGKQFLEKRLQVKQNQHEELQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFK 321
            :||..|||:||||||||||||||||||||:|||::||||||||||||||||.|||||:.||::||
Zfish   273 KGGNSFLERRLQVKQNQHEELQNVRKHIHSCFSSIGCFLLPHPGLKVATNPHFDGRLRGIDDEFK 337

Human   322 RELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAA 386
            |||:|||||||||||||||||.|:|||||||||||||||||||||||||||||||||||||||.|
Zfish   338 RELQNLVPLLLAPENLVEKEIGGAKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLTA 402

Human   387 VAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSVKKMGGDEFCRRYQDQLEAE 451
            ||||:|||.::|||||||:||||||.||:|.|.:.|:.::.|||.||||||.|||.|||:|||.|
Zfish   403 VAGAKDTYNRTMEQVCGGNKPYIAPVDLQRYHDEFKKTSVDQFRGVKKMGGVEFCHRYQEQLETE 467

Human   452 IEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVMGLALIFLC 516
            ::|.|.||:|||:.||||||||||||||||||..|::|.:||||||:.||.|.::|||:.|:.||
Zfish   468 LDEVYTNFVKHNESKNIFYAARTPATLFAVMFVTYMVSTVTGFIGLSFIAALASVVMGVTLLSLC 532

Human   517 TWAYVKYSGEFREIGTVIDQIAETLWEQRSPRKVFSKLFEVTRRRMVHRALSSAQRQRLS 576
            .|:||:||||:||:|..:|.|||.||.|     |...|.|......|.:.:.::.|..|:
Zfish   533 AWSYVRYSGEYREVGVTMDLIAEALWVQ-----VLKPLTEQYMEENVRQTVVNSIRASLT 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATL2	NP_001317392.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		11/46 (24%)
ATL2	NP_001317392.1	GBP	70..341	CDD:280433	228/270 (84%)
atl2	NP_001103492.1	P-loop_NTPase	86..357	CDD:304359	228/270 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330803
Domainoid	1	1.000	491	1.000	Domainoid score	I2897
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56949
Inparanoid	1	1.050	861	1.000	Inparanoid score	I3060
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58971
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		oto45066
orthoMCL	1	0.900	-	-		OOG6_102856
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4011
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.340