DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATL2 and atln-1

DIOPT Version :9

Sequence 1:	NP_001317392.1	Gene:	ATL2 / 64225	HGNCID:	24047	Length:	584	Species:	Homo sapiens
Sequence 2:	NP_001023492.1	Gene:	atln-1 / 177059	WormBaseID:	WBGene00021868	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	525	Identity:	275/525 - (52%)
Similarity:	378/525 - (72%)	Gaps:	19/525 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    36 TTSLGENYEDDDLVNSDEV-----MKKPCPVQIVLAHED-DHNFELDEEALEQILLQEHIRDLNI 94
            ||...|:.|.....::..|     .|:|..|::|...|| ||:|||:.|.||:|||...:.|..:
Worm     3 TTPQNEHNEHQQQQHAGHVEDVLLPKEPQAVRVVEVVEDTDHSFELNTELLEKILLDPKVADKKV 67

Human    95 VVVSVAGAFRKGKSFLLDFMLRYM------------YNKDSQSWIGGNNEPLTGFTWRGGCERET 147
            .|:.||||:||||||||:|.|||:            ...|:..|:..|: ||:||:||||.||:|
Worm    68 AVIGVAGAYRKGKSFLLNFFLRYLTWRSKADKVMGEVELDNSQWMSPNS-PLSGFSWRGGSERDT 131

Human   148 TGIQVWNEVFVIDRPNGTKVAVLLMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQED 212
            .||.:|:|.|::...||.::||||||||||||||||:|||||:||||||.||||:||||||||||
Worm   132 NGILIWSEPFIMKDKNGEEIAVLLMDTQGAFDSQSTVKDCATIFALSTMISSVQIYNLSQNIQED 196

Human   213 DLQHLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEEL 277
            |||||||||||||||:|:...||||:|:||:||||:|||..:|.:||::.|::||:|.:.||.||
Worm   197 DLQHLQLFTEYGRLALEDSASKPFQSLLFLVRDWSFPYEAEFGFQGGQRVLDRRLEVSEKQHAEL 261

Human   278 QNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAPENLVEKEI 342
            |.:|:||.:||.::.|||:|||||||||||:|||:|.||:.:|:::|..::|.||....||.|||
Worm   262 QQLRQHIRSCFEDIRCFLMPHPGLKVATNPNFDGKLVDIENEFQQQLGVMIPRLLDSHALVHKEI 326

Human   343 SGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARDTYCKSMEQVCGGDKP 407
            :|.|:|||:|:||||||:.|::|::||.|||||.||||||||||||.||..|.:.||:|||||.|
Worm   327 NGQKMTCRELLEYFKAYMHIFRGQDLPEPKSMLMATAEANNLAAVASARAVYQREMEEVCGGDTP 391

Human   408 YIAPSDLERKHLDLKEVAIKQFRSVKKMGGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFYAA 472
            |::.::|...|..:|.:||::||:.:||||.:|..::.::||::::|:|.|::|.|:|||:|.:.
Worm   392 YMSTNELLEHHDRVKNIAIREFRNARKMGGVDFSMQFLERLESDLQESYENYLKVNNGKNLFKSM 456

Human   473 RTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVMGLALIFLCTWAYVKYSGEFREIGTVIDQI 537
            |||..|..:|...||.......|||:.||.||:.|:.|.:..|..|||.:|||..||.|..:|..
Worm   457 RTPTVLVTLMIIDYIFQEFFQLIGLDFIAGLCSSVLCLVIGALGVWAYSRYSGHLREAGGYVDDA 521

Human   538 AETLW 542
            ...:|
Worm   522 VTYVW 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATL2	NP_001317392.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		3/7 (43%)
ATL2	NP_001317392.1	GBP	70..341	CDD:280433	165/282 (59%)
atln-1	NP_001023492.1	P-loop_NTPase	43..325	CDD:393306	165/282 (59%)
atln-1	NP_001023492.1	GBP_C	351..>447	CDD:308475	49/95 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I552
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56949
Inparanoid	1	1.050	567	1.000	Inparanoid score	I629
Isobase	1	0.950	-	0	Normalized mean entropy	S2627
OMA	1	1.010	-	-		QHG58971
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0001595
OrthoInspector	1	1.000	-	-		otm16380
orthoMCL	1	0.900	-	-		OOG6_102856
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4011
SonicParanoid	1	1.000	-	-		X1147
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.960