DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SFRP1 and fz2

DIOPT Version :9

Sequence 1:	NP_003003.3	Gene:	SFRP1 / 6422	HGNCID:	10776	Length:	314	Species:	Homo sapiens
Sequence 2:	NP_001262037.1	Gene:	fz2 / 40090	FlyBaseID:	FBgn0016797	Length:	806	Species:	Drosophila melanogaster

Alignment Length:	133	Identity:	47/133 - (35%)
Similarity:	70/133 - (52%)	Gaps:	13/133 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    54 KPP--QCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSL 116
            |.|  :|.:|  .:.:|..:||.....||.:.|||..|...:...:.||:...|....:.||||:
  Fly    58 KDPNLRCEEI--TIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSM 120

Human   117 FAPVCLD---RPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFP-EGD---VCIAMTPPNA 174
            :.|:||:   :|:..||.:||..|..|.|:||.:.|.|||.:.|:..| .||   :|  |..|:.
  Fly   121 YTPICLEDYHKPLPVCRSVCERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLC--MEQPSY 183

Human   175 TEA 177
            |||
  Fly   184 TEA 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SFRP1	NP_003003.3	CRD_SFRP1	52..175	CDD:143552	44/129 (34%)
SFRP1	NP_003003.3	NTR_Sfrp1_like	183..306	CDD:239635
fz2	NP_001262037.1	CRD_FZ5_like	63..182	CDD:143565	41/122 (34%)
fz2	NP_001262037.1	Frizzled	308..618	CDD:279827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810