DRSC/TRiP Functional Genomics Resources

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Protein Alignment SEMA4A and Sema2a

DIOPT Version :10

Sequence 1:XP_054194142.1 Gene:SEMA4A / 64218 HGNCID:10729 Length:766 Species:Homo sapiens
Sequence 2:NP_477507.1 Gene:Sema2a / 36846 FlyBaseID:FBgn0011260 Length:724 Species:Drosophila melanogaster


Alignment Length:618 Identity:184/618 - (29%)
Similarity:294/618 - (47%) Gaps:95/618 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    69 FDTLLLSGDGNTLYVGAREAILALDIQ-------DPGVPRLKNMIPWPASDRKKSECAFKKKSNE 126
            :.|..::.|.:||||||.:.:..:::|       :..|..|:     |..|...| |..|.||..
  Fly    68 YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLE-----PTRDDVVS-CVSKGKSQI 126

Human   127 TQCFNFIRVLVSYNV-THLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKG--QSPFDPAHK 188
            ..|.|.:||:.|.:. ..||.|||.|.:|. .::...:...||.||..:..|.|  :.|:||...
  Fly   127 FDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDN 190

Human   189 HTAVLVD-----GM--LYSGTMNNFLGSEPILMRT-LGSQPVLKTD-NFLRWLHHDA------SF 238
            .||:.|:     |:  |||||...|..::.::.|| |.:....:.: .|.|.|.:|:      :|
  Fly   191 STAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNF 255

Human   239 VAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQ 303
            |.:....:.|||||.|||.|:....:...||:|||||.||||:.||...|.|:|||:|.|:..|:
  Fly   256 VGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE 320

Human   304 LP--FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKET 366
            .|  ||.|:....||:|.   ...:|.||:  ...|...||||:|.:.:|:..|.||:||.:...
  Fly   321 FPFYFNEIQSVYQLPSDK---SRFFATFTT--STNGLIGSAVCSFHINEIQAAFNGKFKEQSSSN 380

Human   367 SRW---TTYRGPETNPRPGSCSVGPSS--DKALTFMKDHFLMDEQV---VGTPLLVKSGVEYTRL 423
            |.|   ...|.||  ||||:|....|:  |..|.|::.|.|||:.|   ...|:..|..:.:|:|
  Fly   381 SAWLPVLNSRVPE--PRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKL 443

Human   424 AVETAQGLD--GHSHLVMYLGTTTGSLHKAVV---SGDSSAHLVEEIQLFPDPEPVRNLQLAPTQ 483
            .|:..: :|  ...::|.|:||..|.::|.|.   :|:|.:.|::..::.|: |.::.::::.|:
  Fly   444 VVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPN-EAIQVMEISQTR 506

Human   484 GAVFVGFSGGVWRVPRANCS-VYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGN 547
            .::::|....:.::..|.|: .|::|..||  |||:|.||.|:.||    .|......||:....
  Fly   507 KSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTC----RPYELDLLQDVANET 565

Human   548 PEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPC----PHLSALASYYWSH---------- 598
            .: .|.|..:.            |:::......:.|.|    |.:.......|.|          
  Fly   566 SD-ICDSSVLK------------KKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEI 617

Human   599 --GPAAVPEASSTVYNGSLLLIVQDGVGGLYQC 629
              .|....|   |...|.:::.|.:..||.|.|
  Fly   618 RYSPTKYIE---TTERGLVVVSVNEADGGRYDC 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEMA4AXP_054194142.1 Sema_4A 60..500 CDD:200517 149/470 (32%)
PSI 501..545 CDD:396154 17/44 (39%)
Ig 571..643 CDD:472250 15/75 (20%)
Ig strand B 581..585 CDD:409456 1/3 (33%)
Ig strand C 593..597 CDD:409456 0/3 (0%)
Ig strand E 612..616 CDD:409456 1/3 (33%)
Ig strand F 626..631 CDD:409456 2/4 (50%)
Sema2aNP_477507.1 Sema_2A 66..523 CDD:200499 149/470 (32%)
PSI 527..>550 CDD:396154 11/24 (46%)
Ig_Semaphorin_C 573..668 CDD:409368 15/90 (17%)
Ig strand A 573..579 CDD:409368 1/17 (6%)
Ig strand B 583..591 CDD:409368 1/7 (14%)
Ig strand C 601..607 CDD:409368 1/5 (20%)
Ig strand C' 609..612 CDD:409368 0/2 (0%)
Ig strand D 622..626 CDD:409368 0/3 (0%)
Ig strand E 630..637 CDD:409368 1/6 (17%)
Ig strand F 643..652 CDD:409368 3/5 (60%)
Ig strand G 655..668 CDD:409368
Blue background indicates that the domain is not in the aligned region.

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