Protein Alignment SEMA4A and Sema1a

DIOPT Version :10

• Sequence 1: XP_054194142.1
• Gene: SEMA4A / 64218
• HGNCID: 10729
• Length: 766
• Species: Homo sapiens
• Sequence 2: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 206/660 - (31%)
• Similarity: 310/660 - (46%)
• Gaps: 91/660 - (13%)

Human    73 LLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLV 137
            |::.|||:|.:|||..:..|.|.|  :...:.:: |.:.:.....|..|.|..|. |.|:||::|
  Fly    99 LVTKDGNSLLIGARNTVFNLSIHD--LVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMV 159

Human   138 SYNVTHLYTCGTFAFSPAC-TFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSG 201
            ..:...|:.|||.:|.|.| |:|....:|.|..:::    |:...|:||.|..|:||.|..||||
  Fly   160 VPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKN----GQAVCPYDPRHNSTSVLADNELYSG 220

Human   202 TMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLH 266
            |:.:|.||:||:.|    :| |:|:.:.....:..:||::......|||||.|||.||....:..
  Fly   221 TVADFSGSDPIIYR----EP-LQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAI 280

Human   267 TSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLP--FNVIRHAVLL---PADSPTAPHIY 326
            .||||||||.|.||....:.:||:|||::|.|:.||..|  ||.|:.|..|   ...|.::..||
  Fly   281 YSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIY 345

Human   327 AVF-TSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPET-NPRPGSCSVGPS 389
            .|| |....:.|   ||||||:|.||...|:|::||.....|.|......:. :||||||.....
  Fly   346 GVFNTPSNSIPG---SAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSR 407

Human   390 S--DKALTFMKDHFLMDEQV---VGTPLLVKSGVEY--TRLAVET-AQGLDGHSHLVMYLGTTTG 446
            :  |..|.|:|.|.||||.|   ...|:||::...|  |::||:. .:...|.::.|:::||..|
  Fly   408 ALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHG 472

Human   447 SLHKAV--VSGDS----SAHLVEEIQLFPDPEPVRNLQLAPT------------QGAVFVGFSGG 493
            .:.|:|  .|.||    ::.::|||.:....||:|||::..|            .|.:.:.....
  Fly   473 KIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQ 537

Human   494 VWRVPRANC--SVYESCVDCVLARDPHCAWDPESRTCCLLSAPNL---NSWKQDMERGNPEWACA 553
            |..:....|  ....||.:||..:||:||||..:..|....||..   |.:.|::..|. ..||.
  Fly   538 VVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ-HAACP 601

Human   554 SGPMSR------------------SLRPQSRPQIIKEVLAVPNSILELPCPHLSA--LASYYWSH 598
            ||.::.                  ..|.||:.|.|     :.|.......|.:||  :.:.|
  Fly   602 SGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEI-----IDNIDKNFEGPQISADIINAQY--- 658

Human   599 GPAAVPEASSTVYNGSLLLIVQDGVGGLY---QCWATE-NGFSYPVISYWVDSQDQTLALDPELA 659
               .|......|..||:..::.....|.:   :|...| :...||...|....|.|.:...|...
  Fly   659 ---TVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSC 720

Human   660 GIPREHVKVP 669
            .|.:|...:|
  Fly   721 RIQQEPKLLP 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEMA4A	XP_054194142.1	Sema_4A	60..500	CDD:200517	159/460 (35%)
		PSI	501..545	CDD:396154	16/48 (33%)
		Ig	571..643	CDD:472250	14/77 (18%)
		Ig strand B	581..585	CDD:409456	0/3 (0%)
		Ig strand C	593..597	CDD:409456	1/3 (33%)
		Ig strand E	612..616	CDD:409456	2/3 (67%)
		Ig strand F	626..631	CDD:409456	1/7 (14%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	159/462 (34%)
		PSI	545..601	CDD:396154	18/56 (32%)