DRSC/TRiP Functional Genomics Resources

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Protein Alignment SEMA4A and Sema2b

DIOPT Version :10

Sequence 1:XP_054194142.1 Gene:SEMA4A / 64218 HGNCID:10729 Length:766 Species:Homo sapiens
Sequence 2:NP_001261024.1 Gene:Sema2b / 246538 FlyBaseID:FBgn0264273 Length:824 Species:Drosophila melanogaster


Alignment Length:632 Identity:192/632 - (30%)
Similarity:287/632 - (45%) Gaps:98/632 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    62 HQKGLQDFD-------TLLLSGDGNTLYVGAREAILALDIQD--PGVPRLKNMIPWP-ASDRKKS 116
            |::.:|||.       |..:....|.|||||.:.|..|::::  ..:.....:|..| .||  ..
  Fly   108 HKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSD--IL 170

Human   117 ECAFKKKSNETQCFNFIRVL--VSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISE--DKVMEG 177
            .|..|.|..:.:|.|.|||:  :::|...||.|||.|.:|....|....:: ||.|:  ..:..|
  Fly   171 NCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTH-LPRSQYVPGIGLG 234

Human   178 KGQSPFDPAHKHTAVLVDG-------MLYSGTMNNFLGSEPILMR------TLGSQPVLKTDNFL 229
            .|:.|:|||...|||.|:.       .||:||...|..::.::.|      |.|.    |..||.
  Fly   235 IGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGR----KEANFK 295

Human   230 RWLHHDA------SFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKW 288
            |.:.:|:      :||.:....:.|||||.|.|.|:....:...||||||||||.||:.::.:.|
  Fly   296 RTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNW 360

Human   289 TTFLKAQLLCTQPGQLP--FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDI 351
            .|:|||::.|:...:.|  ||.|:....:|.|.   ...||.||:  ...|...||||::.:.||
  Fly   361 ATYLKARMNCSISSEFPFYFNEIQSVYKMPTDD---TKFYATFTT--NTNGLIGSAVCSYDIRDI 420

Human   352 ERVFKGKYKELNKETSRW---TTYRGPETNPRPGSC--SVGPSSDKALTFMKDHFLMDEQV---V 408
            ...|.||:||.....|.|   ...:.||  ||||:|  ......|..|.|::.|.|||:.|   .
  Fly   421 NAAFDGKFKEQATSNSAWLPVLNSKVPE--PRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEF 483

Human   409 GTPLLVKSGVEYTRLAVETAQGLD--GHSHLVMYLGTTTGSLHKAVV---SGDSSAHLVEEIQLF 468
            |.|:..|..|..|:|.|:..: :|  ....||.::.||:|.::|.|.   .|...::||:..:..
  Fly   484 GNPVFFKRDVILTKLVVDKIR-IDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEAS 547

Human   469 PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCS-VYESCVDCVLARDPHCAWDPESRTCCLLS 532
            |..||:|.:.|:...|:::|.....|.::..|.|: .|:||..||  .||:|.||.:...|    
  Fly   548 PHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWDKDVNAC---- 606

Human   533 APNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPC----PHLSALAS 593
            .|......||:...      .||....|:       :.|:|.:.....|.|.|    |.:.....
  Fly   607 RPYQLGLLQDVANE------TSGICDTSV-------LRKKVTSSYGQTLHLSCFVKMPEVLRKKQ 658

Human   594 YYWSH-----GPAAVPEASSTVY-----NGSLLLIVQDGVGGLYQCW 630
            ..|.|     |...| ..:.|.|     .|.:||.|.:|.||.|..:
  Fly   659 TRWYHHSTEKGRYEV-RYTPTKYIDTNEGGLVLLAVNEGDGGRYDSY 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SEMA4AXP_054194142.1 Sema_4A 60..500 CDD:200517 153/485 (32%)
PSI 501..545 CDD:396154 15/44 (34%)
Ig 571..643 CDD:472250 20/74 (27%)
Ig strand B 581..585 CDD:409456 2/3 (67%)
Ig strand C 593..597 CDD:409456 0/3 (0%)
Ig strand E 612..616 CDD:409456 1/3 (33%)
Ig strand F 626..631 CDD:409456 1/5 (20%)
Sema2bNP_001261024.1 Sema_2A 120..579 CDD:200499 149/473 (32%)
PSI 583..>606 CDD:396154 10/24 (42%)
Ig 632..724 CDD:472250 20/74 (27%)
Ig strand B 642..646 CDD:409353 2/3 (67%)
Ig strand C 658..662 CDD:409353 0/3 (0%)
Ig strand E 686..690 CDD:409353 1/3 (33%)
Ig strand F 700..705 CDD:409353 1/5 (20%)
Ig strand G 717..720 CDD:409353
Blue background indicates that the domain is not in the aligned region.

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