Protein Alignment LHX5 and Lim1

DIOPT Version :10

• Sequence 1: NP_071758.1
• Gene: LHX5 / 64211
• HGNCID: 14216
• Length: 402
• Species: Homo sapiens
• Sequence 2: NP_572505.1
• Gene: Lim1 / 31813
• FlyBaseID: FBgn0026411
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 194/455 - (42%)
• Similarity: 234/455 - (51%)
• Gaps: 148/455 - (32%)

Human     5 CAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQ 69
            ||||.:||||:||||||:||||..||:||||...|::||||||.||||:||||||:||||:||.|
  Fly    27 CAGCNKPILDKFLLNVLERAWHASCVRCCECLQPLTDKCFSRESKLYCRNDFFRRYGTKCSGCGQ 91

Human    70 GISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYLSSSSLKEGSLNSVS 134
            ||:|||||||.|.||||||||||.:|.|||||||:|||:|:|||:||||||         |....
  Fly    92 GIAPSDLVRKPRDKVFHLNCFTCCICRKQLSTGEQLYVLDDNKFICKDDYL---------LGKAP 147

Human   135 SCTDRSLSPDLQDALQDDPKETD---------------------------------NSTSSDKET 166
            ||...|||..|..:..:|..:.|                                 .|.|:|.:.
  Fly   148 SCGHNSLSDSLMGSASEDDDDDDPPHLRATALGLGVLGPNGPDSAGGPLGTSDISVQSMSTDSKN 212

Human   167 ---------------------ANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIR 210
                                 |.|::.:..:|:|||||||||||||||.||.||..|||||||||
  Fly   213 THDDSDQGSLDGDPDGRGDSQAENKSPDDANGSKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIR 277

Human   211 EQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMR--PLG---GRLDESEM 270
            ||||:||||.||||||||||:|||||||||::::|  |..||...|:||  |:.   |.||:
  Fly   278 EQLAKETGLPMRVIQVWFQNKRSKERRMKQITSMG--RPPFFGGARKMRGFPMNLSPGGLDD--- 337

Human   271 LGSTPYTYYGDYQGDYYAPGSNYDFFAHGPPSQAQSPADSSFLAASGPGSTPLGALEPPLAGPHA 335
                               |..:.:||          ||:.|
  Fly   338 -------------------GPGFPYFA----------ADAKF----------------------- 350

Human   336 ADNPRFTDMISHPDTPSPEPGLPGTLHPMPGEVFSGGPSPPFPMSGTSGYSGPLSH--PNPELNE 398
                              |.|..|..||..|..|.|.|..|.|.:..   .||:.|  |.|.:||
  Fly   351 ------------------EFGYGGPFHPHDGPYFPGHPGGPMPFNAP---GGPMDHSGPIPMVNE 394

Human   399  398
              Fly   395  394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX5	NP_071758.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	36/50 (72%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	42/54 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..186		21/115 (18%)
		Homeodomain	181..237	CDD:459649	48/55 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..402		21/103 (20%)
		PHA03378	<301..>392	CDD:223065	17/92 (18%)
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	36/50 (72%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	42/54 (78%)
		COG5576	185..324	CDD:227863	66/140 (47%)
		Homeodomain	248..304	CDD:459649	48/55 (87%)