Protein Alignment LHX5 and lin-11

DIOPT Version :10

• Sequence 1: NP_071758.1
• Gene: LHX5 / 64211
• HGNCID: 14216
• Length: 402
• Species: Homo sapiens
• Sequence 2: NP_492696.1
• Gene: lin-11 / 172893
• WormBaseID: WBGene00003000
• Length: 405
• Species: Caenorhabditis elegans
• Alignment Length: 376
• Identity: 152/376 - (40%)
• Similarity: 200/376 - (53%)
• Gaps: 66/376 - (17%)

Human     5 CAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQ 69
            ||.|.:|||||::..||.:.||..|::||:|:..:|..||||:|.:.||.||.||:..:||||..
 Worm    68 CAACAQPILDRYVFTVLGKCWHQSCLRCCDCRAPMSMTCFSRDGLILCKTDFSRRYSQRCAGCDG 132

Human    70 GISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYLSSSSLKEGSLNSV- 133
            .:...||||:||.||||:.||.|.||.:.|.||::||:::.|:|||:.|:  .::.|..:..|:
 Worm   133 KLEKEDLVRRARDKVFHIRCFQCSVCQRLLDTGDQLYIMEGNRFVCQSDF--QTATKTSTPTSIH 195

Human   134 ------SSCTDRSLSPDLQDALQDDPKETDNSTSSDKE-TANNENEEQNSGTKRRGPRTTIKAKQ 191
                  |.|.        .|..:|:....|.....|.| ....:|.:.::..|||||||||||||
 Worm   196 RPVSNGSECN--------SDVEEDNVDACDEVGLDDGEGDCGKDNSDDSNSAKRRGPRTTIKAKQ 252

Human   192 LETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPR 256
            |||||.|||||||||||||||||.||||||||||||||||||||||||||...|.|:.   |.||
 Worm   253 LETLKNAFAATPKPTRHIREQLAAETGLNMRVIQVWFQNRRSKERRMKQLRFGGYRQS---RRPR 314

Human   257 RMRPLGGRLDESEMLGSTPYTYYGDYQGDYYAPGSNYDFFAHGPPSQAQSPADSSFLAASGPGST 321
            |          .:::...|               ::..|:...|||..|...|....:.:.|.:.
 Worm   315 R----------DDIVDMFP---------------NDQQFYPPPPPSNVQFFCDPYTTSPNNPETI 354

Human   322 PLGALEPPLAGP-------------HAADNPRFTD----MISHPDTPSPEP 355
            .:.   |..|.|             .:|..|.|.:    .|...|...|.|
 Worm   355 QMA---PQFAVPTENMNMVPEPYTEQSATPPEFNEDTFACIYSTDLGKPTP 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LHX5	NP_071758.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	24/50 (48%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	28/54 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..186		16/69 (23%)
		Homeodomain	181..237	CDD:459649	53/55 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..402		16/75 (21%)
		PHA03378	<301..>392	CDD:223065	15/72 (21%)
lin-11	NP_492696.1	LIM	68..123	CDD:395333	27/54 (50%)
		LIM2_Lhx1_Lhx5	127..182	CDD:188761	28/54 (52%)
		Homeodomain	242..298	CDD:459649	53/55 (96%)