DRSC/TRiP Functional Genomics Resources

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Protein Alignment SFPQ and B52

DIOPT Version :9

Sequence 1:NP_005057.1 Gene:SFPQ / 6421 HGNCID:10774 Length:707 Species:Homo sapiens
Sequence 2:NP_001014619.2 Gene:B52 / 41670 FlyBaseID:FBgn0004587 Length:355 Species:Drosophila melanogaster


Alignment Length:356 Identity:68/356 - (19%)
Similarity:120/356 - (33%) Gaps:85/356 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   298 RLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTPMRGRQL 362
            |::||.||..:.|.:.:|.|..||...::.|.  .|:||::.|....|:.|..||:...:.|.::
  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIK--NGYGFVEFEDYRDADDAVYELNGKELLGERV 67

Human   363 RVRFATHAA--------------------------------------------ALSVRNLSPYVS 383
            .|..|...|                                            .|.|.|||..||
  Fly    68 VVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVS 132

Human   384 NELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIVE 448
            .:.|::...|.|.:..|    |...:...:|:|||||....:.|                     
  Fly   133 WQDLKDYMRQAGEVTYA----DAHKQRRNEGVVEFASLSDMKTA--------------------- 172

Human   449 PLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMK 513
             :|:|||.:     |..:.....::|    |..:.|........|.:|.....:.:..:..::.:
  Fly   173 -IEKLDDTE-----LNGRRIHLVEDR----RGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRR 227

Human   514 DAKDKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEM 578
            .:..:.:|.........::........|.:...|..:.....:.:.:...:.|....:|.|:.  
  Fly   228 SSHSRSKSRSRSKSRGGRSKSKSPVKSRSRSRSRSNKSRDVSKSKSKSHSRTRSRSPKRERDS-- 290

Human   579 MIRQREMEEQMRRQREESYSRMGYMDPRERD 609
              |.|......|..|..|.|:..:.|.|.||
  Fly   291 --RSRSRSVSKRESRSRSRSKSIHRDSRSRD 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SFPQNP_005057.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..273
3 X 3 AA repeats of R-G-G 9..27
RRM1_PSF 296..366 CDD:241031 21/67 (31%)
RRM2_p54nrb_like 372..451 CDD:240779 19/78 (24%)
NOPS_PSF 442..538 CDD:240583 11/95 (12%)
PTZ00121 <499..>599 CDD:173412 11/99 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..707 10/31 (32%)
B52NP_001014619.2 RRM1_SRSF4_like 5..74 CDD:240783 22/70 (31%)
RRM2_SRSF4_like 120..191 CDD:241044 24/101 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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