Protein Alignment IRF2BPL and Pits

DIOPT Version :10

• Sequence 1: NP_078772.1
• Gene: IRF2BPL / 64207
• HGNCID: 14282
• Length: 796
• Species: Homo sapiens
• Sequence 2: NP_001138192.1
• Gene: Pits / 32205
• FlyBaseID: FBgn0030400
• Length: 630
• Species: Drosophila melanogaster
• Alignment Length: 853
• Identity: 253/853 - (29%)
• Similarity: 306/853 - (35%)
• Gaps: 294/853 - (34%)

Human     9 SRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGADRIEFVIETARQLKRAHGCFQDGRSPGPP 73
            ::||.||||||||||||||.||||.|||||||||||||||.|::.|||:||.|...:..||
  Fly     5 TKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRS---- 65

Human    74 PPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQQQQQQQQLNHVDGSSKPA 138
                        .|....:||||||...         |||||.|......|....:...|...|.
  Fly    66 ------------HENGEVSAAAAAAVVL---------QQQQQLQVGPVPGQGPGSHRGGGGGGPP 109

Human   139 VLAAPSGLERYGLSAA--------AAAAAAAAAAVEQRSRFEYPPPPVSLGSS-SHTARLPNGLG 194
              .||.|....|.|.|        |.|||||||||....:..|..|...:|.. .:..:|.:..|
  Fly   110 --GAPPGSGGPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPG 172

Human   195 G---PNGFPKPTPEEGPPELNRQSPNSSSAAASVASRRGTHGGLVTGLPNPGGGGGPQLTVPPNL 256
            |   |......||...||...|             ...|..||   |:|..|.|||.
  Fly   173 GGVRPVRISHMTPHHLPPNATR-------------GGGGAPGG---GVPTAGSGGGS-------- 213

Human   257 LPQTLLNGPASAAVLPPPPP---------------HALGSRGPPTPAPPGAPGGPACLGG----- 301
            ||      ||.:..|..||.               |.|        ||.|:.|.....||
  Fly   214 LP------PALSVNLKRPPSEDVDVDVSQQQQQSGHGL--------APDGSAGNSLSAGGGVSGG 264

Human   302 -TPGVSATSSSASSSTSSSVAEVGVGAGGKRPGSVSSTDQERELKEKQRNAEALAELSESLRNRA 365
             .||:..::....|           |.||:.|
  Fly   265 CPPGIKRSAMDDPS-----------GVGGRPP--------------------------------- 285

Human   366 EEWASKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFDAVSKPGMDYELKLFIEYPTGSGNV 430
                          ||.....|..|.:..:..|.|.......|..|..|
  Fly   286 --------------LTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSFD---------------- 320

Human   431 YSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEKKHGSGDWRLLGDLLPEAVRFFKEGVPGADML 495
                                   :|.||                                .|:.:
  Fly   321 -----------------------ASTFK--------------------------------AANPI 330

Human   496 PQP---YLDASCPMLPTALVSLSRAPSAPPGTGALPPA---APSGRGAAASLR---KRKASPEPP 551
            |.|   :|..:..|.|.     ||...:.|.:|.|||.   :|:..|:::..|   .|..|....
  Fly   331 PNPIPHHLHIAEHMSPA-----SRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHVSSTTV 390

Human   552 DSAEGALKLGEEQQRQQWMANQSEALKLTMSAGGFAAPGHAA-----GGPPPPPPPL-----GPH 606
            .|:|    :|.....|..:|.       .:..||...||..|     |||......|     ||.
  Fly   391 TSSE----VGGSNPGQAVVAG-------GLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPG 444

Human   607 SNRTTPPESAPQNGPSPMAALMSVADTLGTAHSPKDGSSVHSTTASARRNSSSPVSPASVPGQ-- 669
            .:.::........||:.||. .|||.         |||.......|....|...|:|.  ||.
  Fly   445 GSASSGSGGNGAIGPASMAP-NSVAG---------DGSPAGGNGPSGSNGSGGSVNPG--PGSSG 497

Human   670 --------RRLASRNGDL---NLQVAPPPPSAHPGMDQVHPQNIPDSPMANSGPLCCTICHERLE 723
                    ..|||..|..   .|..||...:|.      :......:..|.:..|.||:|.||||
  Fly   498 SQGGGGGGTPLASGGGSAGSGGLGGAPGSSAAS------NSAAAAAAAAAQNATLKCTLCQERLE 556

Human   724 DTHFVQCPSVPSHKFCFPCSRESIKAQGATG-EVYCPSGEKCPLVGSNVPWAFMQGEIATILAGD 787
            ||||||||||..|||||||||||||.|...| |||||||::|||..|.:|||||||||.|||..:
  Fly   557 DTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEE 621

Human   788 VKVKKERD 795
            |||||||:
  Fly   622 VKVKKERE 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRF2BPL	NP_078772.1	IRF-2BP1_2	10..61	CDD:463250	41/50 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..345		42/195 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..556		13/46 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..698		34/135 (25%)
		vRING-HC_IRF2BPL	708..773	CDD:438377	45/65 (69%)
Pits	NP_001138192.1	IRF-2BP1_2	6..57	CDD:463250	41/50 (82%)
		vRING-HC_IRF2BP1-like	546..602	CDD:438174	43/55 (78%)