DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sv2b and CG33233

DIOPT Version :9

Sequence 1:	NP_001103223.1	Gene:	Sv2b / 64176	MGIID:	1927338	Length:	683	Species:	Mus musculus
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	122/575 - (21%)
Similarity:	214/575 - (37%)	Gaps:	130/575 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    92 AHQYETIIDECGHGRFQWTLFFVLGLALMADGVEIFVVSF--ALPSAEKDMCLSSSKKGMLGLIV 154
            |...:|.:...|:|..|..:|.|.....|....|.....:  .|.|.|.|  .|..:|.:|...:
  Fly     3 AMDVDTALLTIGYGLGQVIIFMVSFFIYMYSVTESMTAGYLVVLTSCEFD--TSPKEKTLLANSL 65

Mouse   155 YLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIV 219
            ..||:|....:|.|||:.|||.|:.::|....||:.:|:.:....:....|:|.|..:.....:.
  Fly    66 LGGMVASGLFIGFLADRYGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQ 130

Mouse   220 FAYFSEFLSREKRGEHLSW----LGIFWMTGG---IYASAMAWSIIPHYGWGFSMGTNYHFHSWR 277
            ..:..||       ..:.|    :.|...:.|   ||...:|.:|:|: .:...:.::|:...||
  Fly   131 VGFLGEF-------HAIKWRPITVAICSQSQGLALIYCPLVAMAILPN-NFNVDLSSSYNLRVWR 187

Mouse   278 VFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKT 342
            ..::...:|..:::|.:..:||:|.||:.:.:.|:|.:.||.:  ..|..|...:...|:|..|:
  Fly   188 FLMMFFMIPGWLALVGICLVPETPHFLMSVNRPDKALLALKWI--CRMNRKKWEDVDITLSEEKS 250

Mouse   343 PKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGL 407
            .....|        |.|            |.||.........|:.....|...:.|.:..:..||
  Fly   251 STNDQE--------GFW------------KTVWYEYKLLFSKPHVFKFFICLFLIFGIFFTSIGL 295

Mouse   408 TVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQ-IHQHGKLVNDKFIKMYFKHVLFED 471
            .:||| :||                          .|:|. .::...|||:            ..
  Fly   296 GIWFP-VIR--------------------------NMDNSGSNRLCDLVNN------------NP 321

Mouse   472 TFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFINCRFINSTFLEQKEGCHMDFEEDNDF 536
            ||.:. ..:|...||:....|..|.|...:...|...:|.|..:.|.
  Fly   322 TFINH-EADDTNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASV------------------ 367

Mouse   537 LIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLI----SAVCCFFLFFGNSESAMIGWQC 597
               ||.::....|:..:|:.:::         :|.|:.|    :.|..||:........:|.
  Fly   368 ---LVHWMTRKYVIALHILISMI---------LGISLNIMKQPTVVLIFFVLMMVLPGVLIP--- 417

Mouse   598 LFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGIT 652
              ..||         :.|:..|.|.|..|..::..|.:||.:||:|:...|:.:|
  Fly   418 --LATS---------VLVDCLPVNLRGKALCMVRSLARFGGVLGSTMIGLFIRVT 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sv2b	NP_001103223.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
Sv2b	NP_001103223.1	synapt_SV2	8..683	CDD:130366	122/575 (21%)
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	113/544 (21%)
		MFS	23..>208	CDD:119392	44/194 (23%)
		MFS	354..>482	CDD:304372	30/152 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920