Protein Alignment MAP2K4 and PBS2

DIOPT Version :9

• Sequence 1: NP_001268364.1
• Gene: MAP2K4 / 6416
• HGNCID: 6844
• Length: 410
• Species: Homo sapiens
• Sequence 2: NP_012407.2
• Gene: PBS2 / 853313
• SGDID: S000003664
• Length: 668
• Species: Saccharomyces cerevisiae
• Alignment Length: 439
• Identity: 160/439 - (36%)
• Similarity: 235/439 - (53%)
• Gaps: 84/439 - (19%)

Human     3 APSPSG--------------GGGSGGGS----------GSGTPGP---VG-SPAPGHPAVSSMQG 39
            |||||.              |..|..||          .|.|.||   || :|..|:...||..|
Yeast   246 APSPSNKKHIETLSNSKVVEGKRSNPGSLINGVQSTSTSSSTEGPHDTVGTTPRTGNSNNSSNSG 310

Human    40 FQINFCEKAQSKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQ 104
                     .|....|..||:.                     ::: :::.|:..:|||.:| .:
Yeast   311 ---------SSGGGGLFANFSK---------------------YVD-IKSGSLNFAGKLSLS-SK 343

Human   105 HWDF--------TAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD 161
            ..||        |.::|:.|.|:|.|.||:|:|::|||:..|||.|.:|..:||.:.:|:||:|:
Yeast   344 GIDFSNGSSSRITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELE 408

Human   162 VVMRSSDCPYIVQFYGALFREGDCWICMELM-STSFDKFYKYVYSVLDDV--IPEEILGKITLAT 223
             |:...:.||||.||||.|.||..::|||.| ..|.||    :|....::  |.|..|..|..|.
Yeast   409 -VLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDK----IYDESSEIGGIDEPQLAFIANAV 468

Human   224 VKALNHLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID 287
            :..|..|||...|||||:||:|||.. ..|.:||||||:||.||.|:||| :.||:.|||||||.
Yeast   469 IHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKT-NIGCQSYMAPERIK 532

Human   288 P-SASRQGYDVRSDVWSLGITLYELATGRFPYP--KWNSVFDQLTQVVKGDPPQLSNSEEREFSP 349
            . :..|..|.|:||:||||:::.|:|.||:|||  .::::|.||:.:|.|.||:|.:.   :||.
Yeast   533 SLNPDRATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSD---KFSS 594

Human   350 SFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQ 398
            ...:||:|||.|...:||.|..|.:||:::.|..:.|.::.|:.:.|::
Yeast   595 DAQDFVSLCLQKIPERRPTYAALTEHPWLVKYRNQDVHMSEYITERLER 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K4	NP_001268364.1	PKc_MKK4	106..396	CDD:270790	130/304 (43%)
PBS2	NP_012407.2	PKc_PBS2_like	358..644	CDD:132953	128/295 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040