DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP2K4 and Mkk4

DIOPT Version :9

Sequence 1:	NP_001268364.1	Gene:	MAP2K4 / 6416	HGNCID:	6844	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	404	Identity:	233/404 - (57%)
Similarity:	277/404 - (68%)	Gaps:	36/404 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     4 PSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGFQINFCEKAQSKRKALKLNFANPPFKSTA 68
            |..|....|.|.:.||:.             ||.|...:..|..||..::       .||..|:
  Fly    33 PPSSTSSTSSGSTSSGSS-------------SSSQHNHVTRCFGAQQPQQ-------TPPVASS- 76

Human    69 RFTLNPNP----TGVQNPHIERLRTHSIESSGKLKI---SPEQHWDFTAEDLKDLGEIGRGAYGS 126
              .:.|.|    :...:.|.||:|.   ::.|||:.   ....| .||::||:|.|||||||:|:
  Fly    77 --QVPPVPAASSSSAADRHRERIRQ---QACGKLQFGEGGANTH-TFTSDDLEDEGEIGRGAFGA 135

Human   127 VNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL 191
            ||||..|...::||||||||||||||||||||||:|||:|::|.||||||||||:||||||||||
  Fly   136 VNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMEL 200

Human   192 MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKL 256
            |.||.||||||:|......|||.||.|||:|||.|||:|||.|||||||:|||||||.|.|:|||
  Fly   201 MDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKL 265

Human   257 CDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKW 321
            ||||||||||||||||:|||||||||||||||..:: |||||||||||||||.|:|||.|||.||
  Fly   266 CDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAK-GYDVRSDVWSLGITLMEVATGNFPYRKW 329

Human   322 NSVFDQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERA 385
            :|||:||.|||:|:||:|..| ...|||..|::|||.||.|.||.||||..||:.|||...|...
  Fly   330 DSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSH 394

Human   386 VEVACYVCKILDQM 399
            .:||.||..||:.|
  Fly   395 TDVAVYVADILESM 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K4	NP_001268364.1	PKc_MKK4	106..396	CDD:270790	205/290 (71%)
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	206/291 (71%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	194/264 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159198
Domainoid	1	1.000	395	1.000	Domainoid score	I763
eggNOG	1	0.900	-	-		E1_KOG1006
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48159
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1809
Isobase	1	0.950	-	0	Normalized mean entropy	S1132
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	1	1.000	-	-		oto88817
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	O	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X3433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750