DRSC/TRiP Functional Genomics Resources

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Protein Alignment MAP2K4 and Mkk4

DIOPT Version :10

Sequence 1:NP_001268364.1 Gene:MAP2K4 / 6416 HGNCID:6844 Length:410 Species:Homo sapiens
Sequence 2:NP_477353.1 Gene:Mkk4 / 41020 FlyBaseID:FBgn0024326 Length:424 Species:Drosophila melanogaster


Alignment Length:404 Identity:233/404 - (57%)
Similarity:277/404 - (68%) Gaps:36/404 - (8%)


- Green bases have known domain annotations that are detailed below.


Human     4 PSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGFQINFCEKAQSKRKALKLNFANPPFKSTA 68
            |..|....|.|.:.||:.             ||.|...:..|..||..::       .||..|: 
  Fly    33 PPSSTSSTSSGSTSSGSS-------------SSSQHNHVTRCFGAQQPQQ-------TPPVASS- 76

Human    69 RFTLNPNP----TGVQNPHIERLRTHSIESSGKLKI---SPEQHWDFTAEDLKDLGEIGRGAYGS 126
              .:.|.|    :...:.|.||:|.   ::.|||:.   ....| .||::||:|.|||||||:|:
  Fly    77 --QVPPVPAASSSSAADRHRERIRQ---QACGKLQFGEGGANTH-TFTSDDLEDEGEIGRGAFGA 135

Human   127 VNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL 191
            ||||..|...::||||||||||||||||||||||:|||:|::|.||||||||||:||||||||||
  Fly   136 VNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMEL 200

Human   192 MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKL 256
            |.||.||||||:|......|||.||.|||:|||.|||:|||.|||||||:|||||||.|.|:|||
  Fly   201 MDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKL 265

Human   257 CDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKW 321
            ||||||||||||||||:|||||||||||||||..:: |||||||||||||||.|:|||.|||.||
  Fly   266 CDFGISGQLVDSIAKTKDAGCRPYMAPERIDPERAK-GYDVRSDVWSLGITLMEVATGNFPYRKW 329

Human   322 NSVFDQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERA 385
            :|||:||.|||:|:||:|..| ...|||..|::|||.||.|.||.||||..||:.|||...|...
  Fly   330 DSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSH 394

Human   386 VEVACYVCKILDQM 399
            .:||.||..||:.|
  Fly   395 TDVAVYVADILESM 408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAP2K4NP_001268364.1 PKc_MKK4 106..396 CDD:270790 205/290 (71%)
Mkk4NP_477353.1 PKc_MKK4 115..405 CDD:270790 206/291 (71%)

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