DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP2K4 and lic

DIOPT Version :9

Sequence 1:	NP_001268364.1	Gene:	MAP2K4 / 6416	HGNCID:	6844	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster

Alignment Length:	336	Identity:	173/336 - (51%)
Similarity:	239/336 - (71%)	Gaps:	13/336 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    70 FTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKP 134
            ||:...|.....|      ..:::|...::|. ::.:|..|:.|:.:.::||||||.|:||.||.
  Fly    10 FTIAKEPEAAIVP------PRNLDSRATIQIG-DRTFDIDADSLEKICDLGRGAYGIVDKMRHKQ 67

Human   135 SGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKF 199
            :..::|||||..||:.:||.:|:||||:.||||||||.|.||||::||||.|||||:||||.|||
  Fly    68 TDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKF 132

Human   200 YKYVYSVLDDV-IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG 263
            |..|:  |.|: :.|.:||||.::.|.||::|...||:||||:||||||::|:|.:|:|||||||
  Fly   133 YPKVF--LHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISG 195

Human   264 QLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQL 328
            .||||||||.||||:||||||||||..:...||:|||||||||.:.|:||||:||..|.:.|:||
  Fly   196 YLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQL 260

Human   329 TQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC 393
            .|||:..||:|   .|..|||.|.:|:.:||.|:...||.|::||||.||:.:.:|..:::.:|.
  Fly   261 RQVVEDSPPRL---PEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVA 322

Human   394 KILDQMPATPS 404
            :|||...|.|:
  Fly   323 RILDLPDAQPA 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K4	NP_001268364.1	PKc_MKK4	106..396	CDD:270790	162/290 (56%)
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	161/286 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.860