DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP2K4 and wis1

DIOPT Version :9

Sequence 1:	NP_001268364.1	Gene:	MAP2K4 / 6416	HGNCID:	6844	Length:	410	Species:	Homo sapiens
Sequence 2:	NP_595457.1	Gene:	wis1 / 2541055	PomBaseID:	SPBC409.07c	Length:	605	Species:	Schizosaccharomyces pombe

Alignment Length:	444	Identity:	158/444 - (35%)
Similarity:	229/444 - (51%)	Gaps:	80/444 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     5 SPSGGGGSGGG--------SGSGTPGPVGSP------------APGHPAVSSMQGFQINFCEKAQ 49
            :|..|.|..|.        :|..:..||.||            |..:|.::....|      ..|
pombe   172 TPIVGMGQRGSYPLPNSQLAGRLSNSPVKSPNMPESGLAKSLAAARNPLLNRPTSF------NRQ 230

Human    50 SK-RKA----LKLNFANP-----PFKSTARFTLNPNPT---------------------GVQNPH 83
            :: |:|    |.|:.:||     |....:|..||..||                     |..|
pombe   231 TRIRRAPPGKLDLSNSNPTSPVSPSSMASRRGLNIPPTLKQAVSETPFSTFSDILDAKSGTLN-- 293

Human    84 IERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV 148
               .:..::.:|..:..|....:.....::..|.|:|:|.||.|.|.:|:|:|..||:|.||.::
pombe   294 ---FKNKAVLNSEGVNFSSGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSL 355

Human   149 DEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIP 212
            :|....|::|:||::.::.. ||||.||||.|.||..:||||.|.. |.||.|      ...:..
pombe   356 EEATFNQIIMELDILHKAVS-PYIVDFYGAFFVEGSVFICMEYMDAGSMDKLY------AGGIKD 413

Human   213 EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGC 277
            |.:|.:...|.|:.|..|||...|||||:||:|:|::.:|.:||||||:||.||.||:|| :.||
pombe   414 EGVLARTAYAVVQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKT-NIGC 477

Human   278 RPYMAPERIDPSASRQG---YDVRSDVWSLGITLYELATGRFPYP--KWNSVFDQLTQVVKGDPP 337
            :.|||||||.......|   |.|::||||||:|:.|:|.|.:|||  .:.|:|.||:.:..||||
pombe   478 QSYMAPERIRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPP 542

Human   338 QLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACY 391
            .|.:|    |||...:|||.||.|:.|.||.|.||..||::|.|:...|::|.:
pombe   543 SLPDS----FSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDMASW 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP2K4	NP_001268364.1	PKc_MKK4	106..396	CDD:270790	129/292 (44%)
wis1	NP_595457.1	PKc_PBS2_like	318..600	CDD:132953	129/287 (45%)
wis1	NP_595457.1	S_TKc	322..579	CDD:214567	125/268 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48159
Inparanoid	1	1.050	218	1.000	Inparanoid score	I1053
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	O	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.990