DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrc4 and Fili

DIOPT Version :9

Sequence 1:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	695	Identity:	163/695 - (23%)
Similarity:	270/695 - (38%)	Gaps:	148/695 - (21%)

- Green bases have known domain annotations that are detailed below.

  Rat    13 WNAVLLPVVYLTAQVWILCAAIAAAASAGPQNCPSVCSC--SNQFSKVVCTRRGLSEVPQGIPSN 75
            |....:||:.|.....::......|.      |||.|.|  ....|:.:|....|.:||..:...
  Fly    16 WLCGAIPVLLLLLLTLVILPPETTAF------CPSKCQCLGGEANSRALCVDAALEDVPIQLNPE 74

  Rat    76 TRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSG 140
            |:|:||..|.|:.::.....:: .||:|.|.:|.|..:....|...:.|.||.|..|.::.:...
  Fly    75 TKYINLTVNRIRTLEFSLPFYM-KLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKH 138

  Rat   141 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMC 205
            ||:.|:.|..|.|..|.||::...|.:.:.||:.|||.. ..:..:.:..|:|:..|:.|.....
  Fly   139 AFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTN-NNIVSLEDNCFKGMNTLEVLVFRNN 202

  Rat   206 NIKDMP--NLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLV 268
            .:.|:|  ||..|..|:.|:||.|....:|..||.||..|..|.|..:.:|.::.:||:||.||.
  Fly   203 RLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLK 267

  Rat   269 ELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL-AWWLREYIPTNSTCCGRCHAPM 332
            .|:|:.|||:.:|....:.|..|..|:|..|.::....:.:| .:.|||               :
  Fly   268 HLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRE---------------L 317

  Rat   333 HM-RGRYLVEVDQASFQCSA----------PFIMDAPRDL-----NISE---------------- 365
            |: |..:|..:|..:|..:.          |.:.|.|..|     ||.|
  Fly   318 HLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF 382

  Rat   366 --DRMAELKCRTPPMS---SVKWL--LPNGTV------LSHASRHPRISVLNDGTLNFSRVLLID 417
              |::.:|.....|:.   |:.||  |..|..      :.||:.....::..:.          |
  Fly   383 PVDQLQKLYLGDNPLQCNCSLLWLWRLVTGNFEGVDPGMEHAAGGAVAALAKEA----------D 437

  Rat   418 TGVYTCMVTNVAGNSNASAYLNVSSAELNTPNFSFFTTVTVETTEISPEDITRKYKPVPTTSTGY 482
            ........|.||...:..|.|....||.:..|       .:.|||.|..::.
  Fly   438 DEELADEATAVASTDDGVAALAAYIAEQHIVN-------ALHTTEPSAYELA------------- 482

  Rat   483 QPAYTTSTTVLIQTTRVPKQVPVPSTDTTDKMQT-------SLDEVMKTTKIIIGCFVAVTLLAA 540
                |:|:.......|:.:| .:......||::|       |..|:.....|:......:|.|..
  Fly   483 ----TSSSNRNSGILRMDRQ-QIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVVCAVITCLLV 542

  Rat   541 AML---IVFY-----KLRKRHQQRSTVTAARTVEIIQVDEDI-----PAAASAAATAAPSG---V 589
            ||:   :::|     :.||...:|..:..:::  ||.|.:.|     |.......:....|   |
  Fly   543 AMIGISVLYYLRFVKRRRKLLHERGPMRTSKS--IINVHDRILQGHNPGGLGLGMSMTLGGGNHV 605

  Rat   590 SGEGAVV-----LPTIHDHINYNTYKP--AHGAHWTENSLGNSLH 627
            :|.|..:     ..|:..|.:|:...|  :||        ||..|
  Fly   606 NGLGMTLNYPHHAQTLQAHHHYHQAMPLQSHG--------GNGNH 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	11/34 (32%)
		LRR_8	74..132	CDD:404697	17/57 (30%)
		LRR 1	75..96		6/20 (30%)
		leucine-rich repeat	76..99	CDD:275380	6/22 (27%)
		PPP1R42	96..300	CDD:411060	66/205 (32%)
		LRR 2	99..120		7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR 3	123..144		7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR 4	147..168		7/20 (35%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		LRR 5	171..193		6/21 (29%)
		leucine-rich repeat	172..196	CDD:275380	6/23 (26%)
		LRR 6	196..217		6/22 (27%)
		leucine-rich repeat	197..218	CDD:275380	7/22 (32%)
		LRR 7	218..239		8/20 (40%)
		leucine-rich repeat	219..242	CDD:275380	10/22 (45%)
		LRR 8	242..263		6/20 (30%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		LRR 9	266..287		8/20 (40%)
		leucine-rich repeat	267..288	CDD:275380	7/20 (35%)
		LRRCT	299..350	CDD:214507	10/52 (19%)
		IG_like	358..440	CDD:214653	21/115 (18%)
		Ig strand B	369..373	CDD:409353	1/3 (33%)
		Ig strand C	380..384	CDD:409353	1/3 (33%)
		Ig strand E	406..410	CDD:409353	0/3 (0%)
		Ig strand F	420..425	CDD:409353	0/4 (0%)
		Ig strand G	433..436	CDD:409353	0/2 (0%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	6/22 (27%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	20/60 (33%)
		leucine-rich repeat	122..145	CDD:275380	8/22 (36%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	57/208 (27%)
		leucine-rich repeat	170..193	CDD:275380	6/23 (26%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	18/46 (39%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		leucine-rich repeat	314..338	CDD:275380	8/38 (21%)
		LRR_8	337..397	CDD:404697	9/59 (15%)
		leucine-rich repeat	339..360	CDD:275380	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4398
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960