DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF9 and klp3

DIOPT Version :9

Sequence 1:	XP_005265445.1	Gene:	KIF9 / 64147	HGNCID:	16666	Length:	823	Species:	Homo sapiens
Sequence 2:	NP_594686.1	Gene:	klp3 / 2542195	PomBaseID:	SPAC1834.07	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	541	Identity:	167/541 - (30%)
Similarity:	265/541 - (48%)	Gaps:	77/541 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    45 RVKPTDDFAHEMIRYGDDKRSIDIHLKKDIRRGVVNNQQTDWS--FKLDGVLHDAS-QDLVYETV 106
            |::||:....::   |.:      ::...:....|:.:.:|:|  |..|.|.|.:| |:.::...
pombe     9 RIRPTNQLEQDL---GGN------NVIYPLNDSTVHIETSDYSGNFVFDRVFHPSSTQNDIFSYS 64

Human   107 AKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATENYKHRGILPRALQQVFRMIEERP-THAITV 170
            .:..|.....|||||::.|||||:||||||||...|::..|:.||.|:::|..|.:.| |....|
pombe    65 IESTVDDLFLGYNGTVLAYGQTGSGKTYTMMGIENNFEKEGMTPRMLRRIFDKIRDSPSTTEYEV 129

Human   171 RVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVENP-QGVFIKGLSVHLTSQEEDAFSLLFEGETN 234
            :|||:|||.|.:.||||      .....:|:.|:. |||:::||.....|.|.:|..:|.:|..:
pombe   130 KVSYMEIYMEKIHDLLS------EKNDRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGS 188

Human   235 RIIASHTMNKNSSRSHCIFTIYLEAHSRTLSEEKYITSKINLVDLAGSERLGKSGSEGQVLKEAT 299
            |.:||.:||..|||||.||.:.:........|.:  ..::.||||||||.:||||:.||.|:||.
pombe   189 RAVASTSMNAQSSRSHSIFVLEVVQTDTESGETR--RGRLFLVDLAGSESVGKSGAVGQTLEEAK 251

Human   300 YINKSLSFLEQAIIALGDQKRDHIPFRQCKLTHALKDSLGGNCNMVLVTNIYGEAAQLEETLSSL 364
            .||:|||.|...|.:|.|.|..|:|:|..|||..||:|||||....|:.|...::....||||:|
pombe   252 KINRSLSTLGMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNATETLSTL 316

Human   365 RFASRMKLVTTEPAINEKYDAERMVKNLEKELALLKQELA----------------IHD------ 407
            ||..|.|.:..:..:|    :|..|..::::|.:.|..|:                .|.
pombe   317 RFGHRAKSIKNKAVVN----SELSVDEMKRQLYIYKDALSRCVCGARINNNLDYNNCHSNVWSGE 377

Human   408 -SLTNRTFVTYDPMDEIQIAEINSQVRRYLEGTLDEIDIISLRQ-------IKEVFNQFRVVLSQ 464
             |||.........:.|.:|.:.|..::. .....||..:.|:.:       |..::.:.::.|.|
pombe   378 HSLTLSNLAEKSNLKEAEIIQGNRTIQE-SNNDRDESTVASIHRHNFDSDSINRLYAEAQLELKQ 441

Human   465 QEQEVESTLRRKYTLIDRNDFAAISAIQKAGLVDVDGHLVGEPEGQNFGLGVAPFSTKPG----K 525
            ::..:.||.::...|:     .|:...|:..:..|..|.|......|..|     :.|||    :
pombe   442 RDGVLSSTKQQLSDLM-----TALGDAQERYVELVKNHRVNSNLTANNSL-----NDKPGFTIEQ 496

Human   526 KAKS------KKTFKEPLSSL 540
            |.|:      :..|.:.||:|
pombe   497 KDKNFSINNERNNFLQKLSTL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF9	XP_005265445.1	KISc_KIF9_like	39..371	CDD:276826	128/330 (39%)
KIF9	XP_005265445.1	Kinesin	45..373	CDD:278646	129/332 (39%)
klp3	NP_594686.1	KIP1	1..546	CDD:227392	167/541 (31%)
klp3	NP_594686.1	KISc_KHC_KIF5	1..325	CDD:276820	129/332 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910