DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF9 and klp-4

DIOPT Version :9

Sequence 1:	XP_005265445.1	Gene:	KIF9 / 64147	HGNCID:	16666	Length:	823	Species:	Homo sapiens
Sequence 2:	NP_001359864.1	Gene:	klp-4 / 180608	WormBaseID:	WBGene00002217	Length:	1576	Species:	Caenorhabditis elegans

Alignment Length:	827	Identity:	218/827 - (26%)
Similarity:	361/827 - (43%)	Gaps:	202/827 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    40 VHAFVRVKPTDDFAHEMIRYGDDKRSIDIHLKKDIR----RGVVN------NQQT---DWSF-KL 90
            |...:||:|.            :||.:|:..|..:|    :.|::      |.:|   |.|| ..
Worm    10 VKVAIRVRPF------------NKRELDLKTKSVVRIQKEQCVLHHPIEEKNSKTFTFDHSFCST 62

Human    91 DGVLHD-ASQDLVYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATENYKHRGILPRALQ 154
            |...:| |||:.|...:...||..|..|||..|..|||||:||:|||||..:   ..||:||...
Worm    63 DPHSYDFASQETVSYHLGSGVVENAFSGYNACIFAYGQTGSGKSYTMMGTPD---QPGIIPRVCN 124

Human   155 QVFRMIEERPTHAIT--VRVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVENP-QGVFIKGLSVH 216
            .:|..|:|....:::  |.|||:|||||.:.|||..    ..|...:.:.|:. .|..:.|||:.
Worm   125 DIFTRIQETSNSSLSFKVEVSYMEIYNERVRDLLDP----KKSSKALKVREHKILGPMVDGLSIL 185

Human   217 LTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYLEAHSRTL-------SEEKYITSKI 274
            ..:..|...:||.||..:|.:|:..||..|||||.:|::.:   ::||       |.||  .:||
Worm   186 AVNSFEQISNLLEEGNKSRTVAATNMNAESSRSHAVFSLIV---TQTLHDLENGFSGEK--VAKI 245

Human   275 NLVDLAGSERLGKSGSEGQVLKEATYINKSLSFLEQAIIALGDQ--KRD-HIPFRQCKLTHALKD 336
            :|||||||||.||:|:.|:.|:|...|||||:.|...|.||.::  |:| .||:|...||..|||
Worm   246 SLVDLAGSERAGKTGAVGKRLEEGGNINKSLTTLGMVISALAERNSKKDKFIPYRDSVLTWLLKD 310

Human   337 SLGGNCNMVLVTNIYGEAAQLEETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLEKELALLKQ 401
            |||||...|::..:...|...|||||:||:|.|.|.:.....|||..:| |:::.|.:|:..|:.
Worm   311 SLGGNSRTVMIATLSPAADNYEETLSTLRYADRAKKIVNHAIINEDPNA-RVIRELREEVETLRM 374

Human   402 ELAIHDSLTNRTFVTYDPMDEIQIAE---INSQVRRYLEGTLDEIDIISLRQIKEVFNQFRVVLS 463
            ::    :.|.:.....:.:.| ::||   :.:|:.:..|..|.|.|.::..:.|:: .:..:.:.
Worm   375 QI----TQTKKEHAETEELRE-RLAESERLVAQMNKSWEERLKETDTLNKERQKDL-TEIGISIE 433

Human   464 QQEQEVESTLRRKYTLIDRNDFAAISAIQKAGLVDVDGH-LVGEPE----GQNFGLGV--APFST 521
            ....:||   :.::.|::.|   |..::.:..:..::|. ::|..|    .::.||.:  :..|.
Worm   434 SSGIKVE---KDRFYLVNMN---ADPSLNELLVYYINGSAIIGNSEELETSRDSGLSMTCSDSSR 492

Human   522 KPGKKAK--------------SKKTFKE----------PLSSLARKEGASSPVNGKDLDYVSTSK 562
            :...|.:              :|.|.:|          |:||..|     ..||||.:    |.:
Worm   493 RDDDKERTSIVLRGLGIMRRHAKMTVEEYGGRLRLFVAPMSSECR-----ICVNGKQI----TER 548

Human   563 TQL---------------VPSSKDGDVKDMLSRD----------RETSSIEPLPS---------- 592
            |.|               |...|..|::..:..|          .|.:...|:.|
Worm   549 TLLRNGNRLLVGMNHFFKVNCPKVMDMEQSIMEDSTMFDYNDAWHEVNDANPISSAVDQYMESVT 613

Human   593 ----DSPKEELR----------------------PIRP----DTPPSKPVAFEEF---KNEQGSE 624
                :..|..|.                      |:.|    .||.:.|.....|   .|.:.|.
Worm   614 LKHQEDKKAALEQQYEAFEKYIQSLTAGGFTPSTPMTPGFCLPTPITTPTGLPPFPFPANPKQSV 678

Human   625 INRIF---KENKSILNERRKRASETTQHINAIKREIDVTKEALNFQ------------------K 668
            .::.|   :..:.:..|..||......|.||:.||.::..:.||.:                  :
Worm   679 KSKFFYWAQRKEEMFAESLKRLKADVIHANALVREANMISKELNKKPKRQTTYDVTLQIPASNLR 743

Human   669 SLREKQGKYENKGLMIIDEE-----EFLLILKLKDLKKQYRSEYQDL 710
            .::.|.|::..:.::::..|     :|..:.:|:......|..|.|:
Worm   744 PIKIKAGQFVCEPVIVVRREGMSGSQFWTVSQLESRLVDMRDTYNDM 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF9	XP_005265445.1	KISc_KIF9_like	39..371	CDD:276826	137/358 (38%)
KIF9	XP_005265445.1	Kinesin	45..373	CDD:278646	137/355 (39%)
klp-4	NP_001359864.1	KISc_KIF1A_KIF1B	10..354	CDD:276816	138/367 (38%)
		Kinesin_assoc	351..463	CDD:374417	23/124 (19%)
		FHA	496..545	CDD:214578	12/53 (23%)
		KIF1B	776..840	CDD:372100	4/15 (27%)
		DUF3694	<1239..1293	CDD:372133
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910