DRSC/TRiP Functional Genomics Resources

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Protein Alignment POTEM and Potea

DIOPT Version :9

Sequence 1:NP_001138914.1 Gene:POTEM / 641455 HGNCID:37096 Length:508 Species:Homo sapiens
Sequence 2:NP_001365522.1 Gene:Potea / 67575 MGIID:1914825 Length:2320 Species:Mus musculus


Alignment Length:398 Identity:124/398 - (31%)
Similarity:186/398 - (46%) Gaps:60/398 - (15%)


- Green bases have known domain annotations that are detailed below.


Human   130 EPRYHVRREDLDKLHRAAWWGKVPRKDLIVMLKDTDMNKKDKQKRTALHLASANGNSEVVKLLLD 194
            ||||    :.|.|:|:||..|...|...::.|....::.:|.::|||||.|.|.|..|||.:||.
Mouse    40 EPRY----KPLRKIHQAASDGDTERLQRMISLGKHSVHDRDFKERTALHFACACGQVEVVSILLR 100

Human   195 RRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALL 259
            ..|.::..|....|.|.||||....||..:||:||.|||..|:.|||:||||:..:::.:||.||
Mouse   101 NNCDIDAADMNFITPLMKAVQNWTYECVCILLKHGADPNRKDKNGNTSLHYAVSEDNQTLAKCLL 165

Human   260 LYGADIESKNKHGLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTVLILAVCCGSASIVSLL 324
            .|.|::|.|||.|.|||||.:.|.|.::.|||:|..||::..|...|..|:.|:...|..:|:||
Mouse   166 KYSANMEQKNKDGFTPLLLALKENKIEMAKFLVKMGANIHVFDDMRRNTLLYAIRWDSKDMVNLL 230

Human   325 LEQNIDVSSQDLSGQTAREYAVSSRHNVICQLLSDYKEKQILKVSSENSNPEQDL---KLTSEEE 386
            |::.||...:|:.|.||..||:........::|.:|.|  :|:..:::..||...   |...:..
Mouse   231 LDEGIDFFFRDVFGWTALRYAIEGTSKGSREILMNYDE--MLRRKNKDGIPEYKFFEDKSLDKHP 293

Human   387 SQRLKGS----ENSQPEEMSQEPEINK------------GGDRKVEEEMKKHGSTHMGFPENLPN 435
            :....||    .|....:...|.:|:|            .|:...:.|.||.....:.      .
Mouse   294 NNPTSGSTFPKSNENACKFDDELDISKYVLGTCPNNIHGAGEEGDKSETKKAADVQVW------T 352

Human   436 GATADNGDDGLIP--PRKSRTPESQQF----------------PDTENEQYHSDE---------- 472
            ..|..:...|.:|  .......||..|                .|.|::|..||:          
Mouse   353 NPTLKSSTKGKVPNLNEVGTMTESHHFIKESDLEIESLVETFSYDNEDKQSMSDDGHFSGTTPKW 417

Human   473 -QNDTQKQ 479
             ||||.::
Mouse   418 CQNDTNRK 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTEMNP_001138914.1 Ank_4 143..193 CDD:290365 18/49 (37%)
ANK 167..292 CDD:238125 59/124 (48%)
ANK 1 172..201 14/28 (50%)
ANK repeat 174..203 CDD:293786 14/28 (50%)
Ank_2 177..269 CDD:289560 42/91 (46%)
ANK repeat 205..236 CDD:293786 15/30 (50%)
ANK 2 205..234 14/28 (50%)
ANK 233..357 CDD:238125 50/123 (41%)
ANK repeat 238..269 CDD:293786 14/30 (47%)
ANK 3 238..267 13/28 (46%)
Ank_2 243..335 CDD:289560 39/91 (43%)
ANK repeat 271..302 CDD:293786 14/30 (47%)
ANK 4 271..300 14/28 (50%)
ANK repeat 304..335 CDD:293786 10/30 (33%)
ANK 5 304..333 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..487 28/159 (18%)
PoteaNP_001365522.1 ANK repeat 49..76 CDD:293786 6/26 (23%)
Ank_2 65..>252 CDD:423045 80/186 (43%)
ANK repeat 80..109 CDD:293786 14/28 (50%)
ANK repeat 114..142 CDD:293786 15/27 (56%)
ANK repeat 144..175 CDD:293786 14/30 (47%)
ANK repeat 177..208 CDD:293786 14/30 (47%)
ANK repeat 210..235 CDD:293786 8/24 (33%)
Smc <1772..1994 CDD:224117
DUF3496 1956..2060 CDD:403277
DUF3496 2181..2284 CDD:403277
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
HGNC 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 196 1.000 Inparanoid score I16278
Isobase 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D24863at7742
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24118
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.070

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