Protein Alignment ABCG4 and Atet

DIOPT Version :10

• Sequence 1: NP_071452.2
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_523471.2
• Gene: Atet / 33636
• FlyBaseID: FBgn0020762
• Length: 832
• Species: Drosophila melanogaster
• Alignment Length: 745
• Identity: 351/745 - (47%)
• Similarity: 460/745 - (61%)
• Gaps: 132/745 - (17%)

Human    10 GCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQR-----FSHLPKRSAVDIEFVELSYS 69
            |.|....|:|..|....|..|               ..|:     .||||:|..|||||.::|||
  Fly   104 GLGSNNHALAPKVANNSGGSP---------------NGQKKGTIALSHLPQRPPVDIEFCDISYS 153

Human    70 VREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPR 134
            |.:.   .:||:||:||.:||||...|:..|||||||||||.|||||||:.:.:.|.:|:|.:.|
  Fly   154 VTDS---HRRGFKTILKSVSGKFRNGEITAIMGPSGAGKSTLMNILAGYKTAQLSGSVLINSKER 215

Human   135 ELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKELVTEILTALGLMSCSHTR 197
            .||.|||:||||||||:|:.:|||.|||||:|||||.:.  ...|..:|.|||..:||....:|.
  Fly   216 NLRRFRKLSCYIMQDDVLIANLTVREAMMVAANLKLGKNMISYAKVVVVEEILETIGLKESVNTL 280

Human   198 TALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSA 262
            |..|||||||||:|||||||||||||||||||||||::|||::||::|||:|||||:||||||||
  Fly   281 TCNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSA 345

Human   263 KLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRA 327
            :|||.||.||:|:||||:::|.|..|:|||..||..||:||||||:::|||||||||..|.|..|
  Fly   346 RLFEKFDHLYLLAQGQCVYEGRVKGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDA 410

Human   328 VQNGLC-------------------------------AMA----EKKSSPEKNEVPAPCPPC--P 355
            |::|.|                               |||    |.:..|.::....|..|.  |
  Fly   411 VKSGACKKYAHKDYVLTLAQKGCNNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDP 475

Human   356 PEVDP---------------------------------------------------------IES 363
            .|:.|                                                         ::|
  Fly   476 AELKPPKLETQQSQNSDCSVVNMPTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDS 540

Human   364 HT----------FATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDAS 418
            |.          |.||..|||.||.||:|.:||||.:|||:|..|||::|.:||::|..:|::||
  Fly   541 HESVVTLPNKTGFPTSGWTQFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEAS 605

Human   419 KVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP 483
            |:.:|.||:||..||..|.|:|||:||||.||:||:||||||||||||:|.|||:||:|||:|..
  Fly   606 KIMSNAGCIFFVSLFTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFS 670

Human   484 VVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLF 548
            .||..:||::|.||.|..|..:|..:....:||||||||||||..| ::...|:||||.||.:||
  Fly   671 SVYVLVVYYLTSQPMELERVSMFVLICVLNSLVAQSLGLLIGAGMN-IETGVFLGPVTTIPTILF 734

Human   549 SGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVED 613
            |||||:|.|||.||||.:|:|||||||||.::.||||:|..:.|.:..|.:|.|:..|..:.:::
  Fly   735 SGFFVNFDTIPGYLQWVTYVSYVRYGFEGAMVAIYGMDRAKMQCNQMYCHYRVPKKFLEEMSMDN 799

Human   614 AKLYMDFLVL-GIFFLALRLLAYLVLRYRV 642
            |..::|.:.| |||| |||::||.|||:::
  Fly   800 ALFWVDAVALIGIFF-ALRIIAYFVLRWKL 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCG4	NP_071452.2	3a01204	44..646	CDD:273361	344/711 (48%)
Atet	NP_523471.2	3a01204	137..825	CDD:273361	339/692 (49%)